{"product_id":"9-mbc-60x25mg","title":"9-MBC 100x25mg","description":"\u003cp class=\"\" data-end=\"467\" data-start=\"0\"\u003e\u003cstrong\u003e\u003cstrong data-start=\"377\" data-end=\"392\"\u003e\u003cspan style=\"color: rgb(255, 42, 0);\"\u003e                                         \u003cspan style=\"text-decoration: underline;\"\u003eNOT \u003c\/span\u003e\u003c\/span\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cspan style=\"color: rgb(255, 42, 0); text-decoration: underline;\"\u003eFOR HUMAN CONSUMPTION\u003c\/span\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"\" data-end=\"467\" data-start=\"0\"\u003e\u003cstrong\u003e9-Methyl-β-carboline \u003cmeta charset=\"UTF-8\"\u003e\u003c\/strong\u003e(9-MBC) is a synthetic \u003cstrong data-start=\"116\" data-end=\"131\"\u003eβ-carboline\u003c\/strong\u003e derivative investigated as a \u003cstrong data-start=\"161\" data-end=\"195\"\u003eneurotrophic, pro-dopaminergic\u003c\/strong\u003e research compound. In cell and rodent models it promotes \u003cstrong data-start=\"253\" data-end=\"325\"\u003edopaminergic neuron survival, differentiation, and neurite outgrowth\u003c\/strong\u003e, with signals of \u003cstrong data-start=\"343\" data-end=\"368\"\u003emitochondrial support\u003c\/strong\u003e and \u003cstrong data-start=\"373\" data-end=\"419\"\u003eanti-inflammatory microglial reprogramming\u003c\/strong\u003e. It is \u003cstrong data-start=\"427\" data-end=\"443\"\u003enot approved\u003c\/strong\u003e for human use; evidence is \u003cstrong data-start=\"471\" data-end=\"486\"\u003epreclinical\u003c\/strong\u003e.\u003c\/p\u003e\n\u003chr data-start=\"489\" data-end=\"492\"\u003e\n\u003ch3 data-start=\"494\" data-end=\"550\"\u003eAdditional Benefits of 9-MBC Now Under Investigation\u003c\/h3\u003e\n\u003cdiv class=\"_tableContainer_1rjym_1\"\u003e\n\u003cdiv class=\"group _tableWrapper_1rjym_13 flex w-fit flex-col-reverse\" tabindex=\"-1\"\u003e\n\u003ctable data-start=\"552\" data-end=\"2801\" class=\"w-fit min-w-(--thread-content-width)\"\u003e\n\u003cthead data-start=\"552\" data-end=\"580\"\u003e\n\u003ctr data-start=\"552\" data-end=\"580\"\u003e\n\u003cth data-start=\"552\" data-end=\"562\" data-col-size=\"sm\"\u003eBenefit\u003c\/th\u003e\n\u003cth data-start=\"562\" data-end=\"580\" data-col-size=\"xl\"\u003eKey take-aways\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody data-start=\"591\" data-end=\"2801\"\u003e\n\u003ctr data-start=\"591\" data-end=\"906\"\u003e\n\u003ctd data-start=\"591\" data-end=\"624\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"593\" data-end=\"623\"\u003e1 Dopaminergic neurotrophy\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"624\" data-end=\"906\" data-col-size=\"xl\"\u003eIn primary midbrain cultures and lesion models, 9-MBC increases \u003cstrong data-start=\"690\" data-end=\"711\"\u003eTH⁺ neuron counts\u003c\/strong\u003e, \u003cstrong data-start=\"713\" data-end=\"731\"\u003eneurite length\u003c\/strong\u003e, and \u003cstrong data-start=\"737\" data-end=\"765\"\u003edopamine synthesis genes\u003c\/strong\u003e (TH, DAT), suggesting true trophic action rather than mere MAO inhibition. \u0026lt;br\/\u0026gt;\u0026lt;em\u0026gt;Journal of Neurochemistry; Molecular Neurobiology\u0026lt;\/em\u0026gt;\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"907\" data-end=\"1167\"\u003e\n\u003ctd data-start=\"907\" data-end=\"945\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"909\" data-end=\"944\"\u003e2 Protection in PD toxin models\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"945\" data-end=\"1167\" data-col-size=\"xl\"\u003eAttenuates loss of dopaminergic neurons and motor deficits after \u003cstrong data-start=\"1012\" data-end=\"1022\"\u003e6-OHDA\u003c\/strong\u003e or \u003cstrong data-start=\"1026\" data-end=\"1039\"\u003eMPTP\/MPP⁺\u003c\/strong\u003e, linked to \u003cstrong data-start=\"1051\" data-end=\"1081\"\u003emitochondrial preservation\u003c\/strong\u003e and \u003cstrong data-start=\"1086\" data-end=\"1116\"\u003eoxidative-stress buffering\u003c\/strong\u003e. \u0026lt;br\/\u0026gt;\u0026lt;em\u0026gt;Neuropharmacology; Brain Research\u0026lt;\/em\u0026gt;\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"1168\" data-end=\"1426\"\u003e\n\u003ctd data-start=\"1168\" data-end=\"1198\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"1170\" data-end=\"1197\"\u003e3 Mitochondrial support\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"1198\" data-end=\"1426\" data-col-size=\"xl\"\u003eImproves \u003cstrong data-start=\"1209\" data-end=\"1235\"\u003ecomplex I\/III activity\u003c\/strong\u003e and \u003cstrong data-start=\"1240\" data-end=\"1262\"\u003emembrane potential\u003c\/strong\u003e, raises \u003cstrong data-start=\"1271\" data-end=\"1291\"\u003ePGC-1α\/NRF1\/TFAM\u003c\/strong\u003esignaling, and lowers \u003cstrong data-start=\"1314\" data-end=\"1323\"\u003emtROS\u003c\/strong\u003e, pointing to a bioenergetic mechanism. \u0026lt;br\/\u0026gt;\u0026lt;em\u0026gt;Redox Biology; Journal of Neuroscience Research\u0026lt;\/em\u0026gt;\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"1427\" data-end=\"1668\"\u003e\n\u003ctd data-start=\"1427\" data-end=\"1457\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"1429\" data-end=\"1456\"\u003e4 Microglial modulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"1457\" data-end=\"1668\" data-col-size=\"xl\"\u003eShifts microglia toward a \u003cstrong data-start=\"1485\" data-end=\"1512\"\u003epro-resolving phenotype\u003c\/strong\u003e, lowering \u003cstrong data-start=\"1523\" data-end=\"1538\"\u003eTNF-α\/IL-1β\u003c\/strong\u003e and increasing trophic cues (e.g., \u003cstrong data-start=\"1574\" data-end=\"1587\"\u003eBDNF\/GDNF\u003c\/strong\u003e signals) in injured striatum. \u0026lt;br\/\u0026gt;\u0026lt;em\u0026gt;Glia; Journal of Neuroinflammation\u0026lt;\/em\u0026gt;\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"1669\" data-end=\"1933\"\u003e\n\u003ctd data-start=\"1669\" data-end=\"1704\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"1671\" data-end=\"1703\"\u003e5 Adult neurogenesis signals\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"1704\" data-end=\"1933\" data-col-size=\"xl\"\u003eIn hippocampal paradigms, increases \u003cstrong data-start=\"1742\" data-end=\"1756\"\u003eDCX⁺\/BrdU⁺\u003c\/strong\u003e indices and dendritic maturation; behavioral readouts suggest \u003cstrong data-start=\"1819\" data-end=\"1843\"\u003ememory consolidation\u003c\/strong\u003e benefits in stress models. \u0026lt;br\/\u0026gt;\u0026lt;em\u0026gt;Hippocampus; Neurobiology of Learning \u0026amp; Memory\u0026lt;\/em\u0026gt;\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"1934\" data-end=\"2093\"\u003e\n\u003ctd data-start=\"1934\" data-end=\"1962\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"1936\" data-end=\"1961\"\u003e6 Synaptic plasticity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"1962\" data-end=\"2093\" data-col-size=\"xl\"\u003eUpregulates \u003cstrong data-start=\"1976\" data-end=\"1996\"\u003ePSD-95, synapsin\u003c\/strong\u003e, and \u003cstrong data-start=\"2002\" data-end=\"2014\"\u003eCREB\/ERK\u003c\/strong\u003e pathways; improves LTP readouts ex vivo. \u0026lt;br\/\u0026gt;\u0026lt;em\u0026gt;Synapse; Neuroscience\u0026lt;\/em\u0026gt;\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"2094\" data-end=\"2350\"\u003e\n\u003ctd data-start=\"2094\" data-end=\"2122\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"2096\" data-end=\"2121\"\u003e7 Anti-excitotoxicity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"2122\" data-end=\"2350\" data-col-size=\"xl\"\u003eMitigates \u003cstrong data-start=\"2134\" data-end=\"2152\"\u003eglutamate\/NMDA\u003c\/strong\u003e injury via \u003cstrong data-start=\"2164\" data-end=\"2181\"\u003eCa²⁺ handling\u003c\/strong\u003e, \u003cstrong data-start=\"2183\" data-end=\"2218\"\u003eantioxidant enzymes (SOD2, GPx)\u003c\/strong\u003e, and maintenance of \u003cstrong data-start=\"2239\" data-end=\"2269\"\u003emitochondrial permeability\u003c\/strong\u003e thresholds. \u0026lt;br\/\u0026gt;\u0026lt;em\u0026gt;Experimental Neurology; Neurochemistry International\u0026lt;\/em\u0026gt;\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"2351\" data-end=\"2542\"\u003e\n\u003ctd data-start=\"2351\" data-end=\"2389\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"2353\" data-end=\"2388\"\u003e8 Myelin\/axon support (signals)\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"2389\" data-end=\"2542\" data-col-size=\"xl\"\u003eEnhances \u003cstrong data-start=\"2400\" data-end=\"2427\"\u003eneurite\/axon elongation\u003c\/strong\u003e and may stabilize oligodendroglial support in mixed cultures—early evidence only. \u0026lt;br\/\u0026gt;\u0026lt;em\u0026gt;Cells; ASN Neuro\u0026lt;\/em\u0026gt;\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"2543\" data-end=\"2801\"\u003e\n\u003ctd data-start=\"2543\" data-end=\"2579\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"2545\" data-end=\"2578\"\u003e9 Depression\/anhedonia models\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"2579\" data-end=\"2801\" data-col-size=\"xl\"\u003eNormalizes \u003cstrong data-start=\"2592\" data-end=\"2614\"\u003esucrose preference\u003c\/strong\u003e, \u003cstrong data-start=\"2616\" data-end=\"2646\"\u003enovelty-suppressed feeding\u003c\/strong\u003e, and \u003cstrong data-start=\"2652\" data-end=\"2678\"\u003eforced-swim immobility\u003c\/strong\u003e in stress rodents, paralleling increases in \u003cstrong data-start=\"2723\" data-end=\"2731\"\u003eBDNF\u003c\/strong\u003e. \u0026lt;br\/\u0026gt;\u0026lt;em\u0026gt;Translational Psychiatry; Behavioural Brain Research\u0026lt;\/em\u0026gt;\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr data-start=\"2803\" data-end=\"2806\"\u003e\n\u003ch2 data-start=\"2808\" data-end=\"2843\"\u003e2. Molecular Mechanism of Action\u003c\/h2\u003e\n\u003ch3 data-start=\"2845\" data-end=\"2885\"\u003e2.1 Pharmacodynamics (working model)\u003c\/h3\u003e\n\u003cul data-start=\"2886\" data-end=\"3441\"\u003e\n\u003cli data-start=\"2886\" data-end=\"3015\"\u003e\n\u003cp data-start=\"2888\" data-end=\"3015\"\u003e\u003cstrong data-start=\"2888\" data-end=\"2918\"\u003ePro-dopaminergic trophism:\u003c\/strong\u003e Upregulates \u003cstrong data-start=\"2931\" data-end=\"2948\"\u003eTH, AADC, DAT\u003c\/strong\u003e expression, enhances dopaminergic differentiation and maintenance.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"3016\" data-end=\"3143\"\u003e\n\u003cp data-start=\"3018\" data-end=\"3143\"\u003e\u003cstrong data-start=\"3018\" data-end=\"3049\"\u003eMitochondrial preservation:\u003c\/strong\u003e Supports \u003cstrong data-start=\"3059\" data-end=\"3069\"\u003eOXPHOS\u003c\/strong\u003e, reduces \u003cstrong data-start=\"3079\" data-end=\"3088\"\u003emtROS\u003c\/strong\u003e, and may activate \u003cstrong data-start=\"3107\" data-end=\"3122\"\u003eAMPK→PGC-1α\u003c\/strong\u003ebiogenesis programs.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"3144\" data-end=\"3249\"\u003e\n\u003cp data-start=\"3146\" data-end=\"3249\"\u003e\u003cstrong data-start=\"3146\" data-end=\"3176\"\u003eNeuroinflammation control:\u003c\/strong\u003e Microglial \u003cstrong data-start=\"3188\" data-end=\"3197\"\u003eNF-κB\u003c\/strong\u003e restraint and increased neurotrophic factor milieu.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"3250\" data-end=\"3441\"\u003e\n\u003cp data-start=\"3252\" data-end=\"3441\"\u003e\u003cstrong data-start=\"3252\" data-end=\"3271\"\u003eEnzyme targets:\u003c\/strong\u003e Unlike harmine\/harmaline, \u003cstrong data-start=\"3298\" data-end=\"3342\"\u003estrong MAO-A\/B inhibition is not central\u003c\/strong\u003e to 9-MBC’s effects at trophic concentrations (some weak, context-dependent interactions reported).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3 data-start=\"3443\" data-end=\"3470\"\u003e2.2 Down-stream biology\u003c\/h3\u003e\n\u003cdiv class=\"_tableContainer_1rjym_1\"\u003e\n\u003cdiv class=\"group _tableWrapper_1rjym_13 flex w-fit flex-col-reverse\" tabindex=\"-1\"\u003e\n\u003ctable data-start=\"3472\" data-end=\"3824\" class=\"w-fit min-w-(--thread-content-width)\"\u003e\n\u003cthead data-start=\"3472\" data-end=\"3514\"\u003e\n\u003ctr data-start=\"3472\" data-end=\"3514\"\u003e\n\u003cth data-start=\"3472\" data-end=\"3482\" data-col-size=\"sm\"\u003ePathway\u003c\/th\u003e\n\u003cth data-start=\"3482\" data-end=\"3503\" data-col-size=\"sm\"\u003eFunctional outcome\u003c\/th\u003e\n\u003cth data-start=\"3503\" data-end=\"3514\" data-col-size=\"sm\"\u003eContext\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody data-start=\"3529\" data-end=\"3824\"\u003e\n\u003ctr data-start=\"3529\" data-end=\"3608\"\u003e\n\u003ctd data-start=\"3529\" data-end=\"3552\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"3531\" data-end=\"3551\"\u003ePGC-1α\/NRF1\/TFAM\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"3552\" data-end=\"3594\" data-col-size=\"sm\"\u003eMitochondrial biogenesis, ATP stability\u003c\/td\u003e\n\u003ctd data-start=\"3594\" data-end=\"3608\" data-col-size=\"sm\"\u003eDA neurons\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"3609\" data-end=\"3680\"\u003e\n\u003ctd data-start=\"3609\" data-end=\"3629\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"3611\" data-end=\"3628\"\u003eERK\/CREB\/BDNF\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"3629\" data-end=\"3656\" data-col-size=\"sm\"\u003eSynaptic plasticity, LTP\u003c\/td\u003e\n\u003ctd data-start=\"3656\" data-end=\"3680\" data-col-size=\"sm\"\u003eHippocampus\/striatum\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"3681\" data-end=\"3760\"\u003e\n\u003ctd data-start=\"3681\" data-end=\"3703\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"3683\" data-end=\"3702\"\u003eNF-κB restraint\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"3703\" data-end=\"3737\" data-col-size=\"sm\"\u003e↓ TNF-α\/IL-1β, microglial shift\u003c\/td\u003e\n\u003ctd data-start=\"3737\" data-end=\"3760\" data-col-size=\"sm\"\u003eInjury\/inflammation\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"3761\" data-end=\"3824\"\u003e\n\u003ctd data-start=\"3761\" data-end=\"3787\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"3763\" data-end=\"3786\"\u003eAntioxidant enzymes\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"3787\" data-end=\"3808\" data-col-size=\"sm\"\u003e↓ Oxidative damage\u003c\/td\u003e\n\u003ctd data-start=\"3808\" data-end=\"3824\" data-col-size=\"sm\"\u003eToxin models\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr data-start=\"3826\" data-end=\"3829\"\u003e\n\u003ch2 data-start=\"3831\" data-end=\"3872\"\u003e3. Pharmacokinetics (preclinical only)\u003c\/h2\u003e\n\u003cul data-start=\"3874\" data-end=\"4201\"\u003e\n\u003cli data-start=\"3874\" data-end=\"4006\"\u003e\n\u003cp data-start=\"3876\" data-end=\"4006\"\u003e\u003cstrong data-start=\"3876\" data-end=\"3886\"\u003eRoute:\u003c\/strong\u003e Effective in \u003cstrong data-start=\"3900\" data-end=\"3919\"\u003esystemic dosing\u003c\/strong\u003e in rodents (IP\/PO in reports); good \u003cstrong data-start=\"3956\" data-end=\"3977\"\u003ebrain penetration\u003c\/strong\u003e inferred from CNS effects.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"4007\" data-end=\"4080\"\u003e\n\u003cp data-start=\"4009\" data-end=\"4080\"\u003e\u003cstrong data-start=\"4009\" data-end=\"4032\"\u003eHalf-life\/exposure:\u003c\/strong\u003e Hours-scale in animals; human PK \u003cstrong data-start=\"4066\" data-end=\"4077\"\u003eunknown\u003c\/strong\u003e.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"4081\" data-end=\"4201\"\u003e\n\u003cp data-start=\"4083\" data-end=\"4201\"\u003e\u003cstrong data-start=\"4083\" data-end=\"4098\"\u003eMetabolism:\u003c\/strong\u003e Likely hepatic oxidative metabolism typical of β-carbolines; detailed metabolite map not standardized.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-start=\"4203\" data-end=\"4206\"\u003e\n\u003ch2 data-start=\"4208\" data-end=\"4230\"\u003e4. Evidence Summary\u003c\/h2\u003e\n\u003cul data-start=\"4232\" data-end=\"4598\"\u003e\n\u003cli data-start=\"4232\" data-end=\"4359\"\u003e\n\u003cp data-start=\"4234\" data-end=\"4359\"\u003e\u003cstrong data-start=\"4234\" data-end=\"4247\"\u003eIn vitro:\u003c\/strong\u003e Robust dopaminergic neuritogenesis and survival across primary cultures; synergy with \u003cstrong data-start=\"4334\" data-end=\"4347\"\u003eGDNF\/BDNF\u003c\/strong\u003epathways.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"4360\" data-end=\"4526\"\u003e\n\u003cp data-start=\"4362\" data-end=\"4526\"\u003e\u003cstrong data-start=\"4362\" data-end=\"4374\"\u003eIn vivo:\u003c\/strong\u003e Neuroprotection and functional improvement in \u003cstrong data-start=\"4421\" data-end=\"4433\"\u003ePD toxin\u003c\/strong\u003e and \u003cstrong data-start=\"4438\" data-end=\"4459\"\u003estress\/depression\u003c\/strong\u003e models; hints of \u003cstrong data-start=\"4477\" data-end=\"4499\"\u003eadult neurogenesis\u003c\/strong\u003e and \u003cstrong data-start=\"4504\" data-end=\"4517\"\u003ecognitive\u003c\/strong\u003e gains.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"4527\" data-end=\"4598\"\u003e\n\u003cp data-start=\"4529\" data-end=\"4598\"\u003e\u003cstrong data-start=\"4529\" data-end=\"4548\"\u003eNo human trials\u003c\/strong\u003e to date; all efficacy claims are \u003cstrong data-start=\"4582\" data-end=\"4597\"\u003epreclinical\u003c\/strong\u003e.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cblockquote data-start=\"4600\" data-end=\"4819\"\u003e\n\u003cp data-start=\"4602\" data-end=\"4819\"\u003e\u003cstrong data-start=\"4602\" data-end=\"4628\"\u003eEvidence quality note:\u003c\/strong\u003e Convergent cellular and rodent data support \u003cstrong data-start=\"4673\" data-end=\"4727\"\u003edopaminergic trophism and mitochondrial protection\u003c\/strong\u003e. Translation to humans is \u003cstrong data-start=\"4754\" data-end=\"4766\"\u003eunproven\u003c\/strong\u003e; dosing windows and long-term safety remain unknown.\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003chr data-start=\"4821\" data-end=\"4824\"\u003e\n\u003ch2 data-start=\"4826\" data-end=\"4872\"\u003e5. Emerging Clinical Interests (conceptual)\u003c\/h2\u003e\n\u003cdiv class=\"_tableContainer_1rjym_1\"\u003e\n\u003cdiv class=\"group _tableWrapper_1rjym_13 flex w-fit flex-col-reverse\" tabindex=\"-1\"\u003e\n\u003ctable data-start=\"4874\" data-end=\"5293\" class=\"w-fit min-w-(--thread-content-width)\"\u003e\n\u003cthead data-start=\"4874\" data-end=\"4904\"\u003e\n\u003ctr data-start=\"4874\" data-end=\"4904\"\u003e\n\u003cth data-start=\"4874\" data-end=\"4882\" data-col-size=\"md\"\u003eField\u003c\/th\u003e\n\u003cth data-start=\"4882\" data-end=\"4894\" data-col-size=\"md\"\u003eRationale\u003c\/th\u003e\n\u003cth data-start=\"4894\" data-end=\"4904\" data-col-size=\"sm\"\u003eStatus\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody data-start=\"4919\" data-end=\"5293\"\u003e\n\u003ctr data-start=\"4919\" data-end=\"5035\"\u003e\n\u003ctd data-start=\"4919\" data-end=\"4967\" data-col-size=\"md\"\u003e\u003cstrong data-start=\"4921\" data-end=\"4966\"\u003eParkinson’s disease (adjunct or prodrome)\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"4967\" data-end=\"5020\" data-col-size=\"md\"\u003eDA neuron protection\/trophism + microglial control\u003c\/td\u003e\n\u003ctd data-start=\"5020\" data-end=\"5035\" data-col-size=\"sm\"\u003ePreclinical\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"5036\" data-end=\"5128\"\u003e\n\u003ctd data-start=\"5036\" data-end=\"5080\" data-col-size=\"md\"\u003e\u003cstrong data-start=\"5038\" data-end=\"5079\"\u003ePost-toxin\/trauma dopaminergic injury\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"5080\" data-end=\"5113\" data-col-size=\"md\"\u003eRegeneration\/neurite outgrowth\u003c\/td\u003e\n\u003ctd data-start=\"5113\" data-end=\"5128\" data-col-size=\"sm\"\u003ePreclinical\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"5129\" data-end=\"5226\"\u003e\n\u003ctd data-start=\"5129\" data-end=\"5162\" data-col-size=\"md\"\u003e\u003cstrong data-start=\"5131\" data-end=\"5161\"\u003eCognitive impairment\/aging\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"5162\" data-end=\"5211\" data-col-size=\"md\"\u003eSynaptic plasticity + hippocampal neurogenesis\u003c\/td\u003e\n\u003ctd data-start=\"5211\" data-end=\"5226\" data-col-size=\"sm\"\u003ePreclinical\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"5227\" data-end=\"5293\"\u003e\n\u003ctd data-start=\"5227\" data-end=\"5254\" data-col-size=\"md\"\u003e\u003cstrong data-start=\"5229\" data-end=\"5253\"\u003eDepression\/anhedonia\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"5254\" data-end=\"5278\" data-col-size=\"md\"\u003ePlasticity\/BDNF angle\u003c\/td\u003e\n\u003ctd data-start=\"5278\" data-end=\"5293\" data-col-size=\"sm\"\u003ePreclinical\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr data-start=\"5295\" data-end=\"5298\"\u003e\n\u003ch2 data-start=\"5300\" data-end=\"5357\"\u003e6. Safety and Tolerability (unknowns \u0026amp; class cautions)\u003c\/h2\u003e\n\u003cul data-start=\"5359\" data-end=\"6375\"\u003e\n\u003cli data-start=\"5359\" data-end=\"5410\"\u003e\n\u003cp data-start=\"5361\" data-end=\"5410\"\u003e\u003cstrong data-start=\"5361\" data-end=\"5378\"\u003eHuman safety:\u003c\/strong\u003e \u003cstrong data-start=\"5379\" data-end=\"5391\"\u003eUnknown.\u003c\/strong\u003e No phase-1 data.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"5411\" data-end=\"5629\"\u003e\n\u003cp data-start=\"5413\" data-end=\"5629\"\u003e\u003cstrong data-start=\"5413\" data-end=\"5456\"\u003eGenotoxic\/phototoxic potential (class):\u003c\/strong\u003e Planar \u003cstrong data-start=\"5464\" data-end=\"5480\"\u003eβ-carbolines\u003c\/strong\u003e can intercalate DNA and, at high doses or UV exposure, show \u003cstrong data-start=\"5541\" data-end=\"5565\"\u003ephototoxic\/genotoxic\u003c\/strong\u003e risks in some assays; 9-MBC-specific margins are not defined.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"5630\" data-end=\"5793\"\u003e\n\u003cp data-start=\"5632\" data-end=\"5793\"\u003e\u003cstrong data-start=\"5632\" data-end=\"5653\"\u003eMAO interactions:\u003c\/strong\u003e Although not a strong MAO inhibitor at trophic doses, \u003cstrong data-start=\"5708\" data-end=\"5719\"\u003ecaution\u003c\/strong\u003e with \u003cstrong data-start=\"5725\" data-end=\"5746\"\u003eMAOI\/serotonergic\u003c\/strong\u003ecombinations is prudent until characterized.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"5794\" data-end=\"5931\"\u003e\n\u003cp data-start=\"5796\" data-end=\"5931\"\u003e\u003cstrong data-start=\"5796\" data-end=\"5818\"\u003eSeizure threshold:\u003c\/strong\u003e High doses of some β-carbolines lower seizure threshold; relevance to 9-MBC is unclear—avoid in epilepsy risk.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"5932\" data-end=\"6095\"\u003e\n\u003cp data-start=\"5934\" data-end=\"6095\"\u003e\u003cstrong data-start=\"5934\" data-end=\"5960\"\u003eCardiac\/mitochondrial:\u003c\/strong\u003e Excessive mitochondrial modulation could theoretically affect \u003cstrong data-start=\"6023\" data-end=\"6049\"\u003econductance\/energetics\u003c\/strong\u003e—ECG and metabolic safety need formal study.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"6096\" data-end=\"6222\"\u003e\n\u003cp data-start=\"6098\" data-end=\"6222\"\u003e\u003cstrong data-start=\"6098\" data-end=\"6124\"\u003eReproductive\/oncology:\u003c\/strong\u003e No data; avoid in \u003cstrong data-start=\"6143\" data-end=\"6156\"\u003epregnancy\u003c\/strong\u003e and in \u003cstrong data-start=\"6164\" data-end=\"6185\"\u003eactive malignancy\u003c\/strong\u003e until carcinogenicity is excluded.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"6223\" data-end=\"6375\"\u003e\n\u003cp data-start=\"6225\" data-end=\"6375\"\u003e\u003cstrong data-start=\"6225\" data-end=\"6245\"\u003eProduct quality:\u003c\/strong\u003e Grey-market “nootropic” supplies are \u003cstrong data-start=\"6283\" data-end=\"6298\"\u003eunregulated\u003c\/strong\u003e and frequently \u003cstrong data-start=\"6314\" data-end=\"6331\"\u003emisidentified\u003c\/strong\u003e—avoid human use outside regulated research.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-start=\"6377\" data-end=\"6435\"\u003e\u003cstrong data-start=\"6377\" data-end=\"6435\"\u003eComparative snapshot (dopaminergic-trophic strategies)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"_tableContainer_1rjym_1\"\u003e\n\u003cdiv class=\"group _tableWrapper_1rjym_13 flex w-fit flex-col-reverse\" tabindex=\"-1\"\u003e\n\u003ctable data-start=\"6437\" data-end=\"6908\" class=\"w-fit min-w-(--thread-content-width)\"\u003e\n\u003cthead data-start=\"6437\" data-end=\"6515\"\u003e\n\u003ctr data-start=\"6437\" data-end=\"6515\"\u003e\n\u003cth data-start=\"6437\" data-end=\"6447\" data-col-size=\"sm\"\u003eFeature\u003c\/th\u003e\n\u003cth data-start=\"6447\" data-end=\"6459\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"6449\" data-end=\"6458\"\u003e9-MBC\u003c\/strong\u003e\u003c\/th\u003e\n\u003cth data-start=\"6459\" data-end=\"6487\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"6461\" data-end=\"6486\"\u003eSelegiline\/rasagiline\u003c\/strong\u003e\u003c\/th\u003e\n\u003cth data-start=\"6487\" data-end=\"6515\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"6489\" data-end=\"6513\"\u003eGDNF (intracerebral)\u003c\/strong\u003e\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody data-start=\"6534\" data-end=\"6908\"\u003e\n\u003ctr data-start=\"6534\" data-end=\"6661\"\u003e\n\u003ctd data-start=\"6534\" data-end=\"6551\" data-col-size=\"sm\"\u003ePrimary action\u003c\/td\u003e\n\u003ctd data-start=\"6551\" data-end=\"6596\" data-col-size=\"sm\"\u003e\n\u003cstrong data-start=\"6553\" data-end=\"6583\"\u003eNeurotrophic\/mitochondrial\u003c\/strong\u003e β-carboline\u003c\/td\u003e\n\u003ctd data-start=\"6596\" data-end=\"6633\" data-col-size=\"sm\"\u003eMAO-B inhibition (neuroprotection)\u003c\/td\u003e\n\u003ctd data-start=\"6633\" data-end=\"6661\" data-col-size=\"sm\"\u003eDirect trophic signaling\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"6662\" data-end=\"6763\"\u003e\n\u003ctd data-start=\"6662\" data-end=\"6673\" data-col-size=\"sm\"\u003eEvidence\u003c\/td\u003e\n\u003ctd data-start=\"6673\" data-end=\"6691\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"6675\" data-end=\"6690\"\u003ePreclinical\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"6691\" data-end=\"6731\" data-col-size=\"sm\"\u003eHuman (symptomatic + some protection)\u003c\/td\u003e\n\u003ctd data-start=\"6731\" data-end=\"6763\" data-col-size=\"sm\"\u003eHuman surgical trials, mixed\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"6764\" data-end=\"6838\"\u003e\n\u003ctd data-start=\"6764\" data-end=\"6775\" data-col-size=\"sm\"\u003eDelivery\u003c\/td\u003e\n\u003ctd data-start=\"6775\" data-end=\"6805\" data-col-size=\"sm\"\u003eOral feasible (preclinical)\u003c\/td\u003e\n\u003ctd data-start=\"6805\" data-end=\"6812\" data-col-size=\"sm\"\u003eOral\u003c\/td\u003e\n\u003ctd data-start=\"6812\" data-end=\"6838\" data-col-size=\"sm\"\u003eNeurosurgical infusion\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"6839\" data-end=\"6908\"\u003e\n\u003ctd data-start=\"6839\" data-end=\"6854\" data-col-size=\"sm\"\u003eSafety known\u003c\/td\u003e\n\u003ctd data-start=\"6854\" data-end=\"6863\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"6856\" data-end=\"6862\"\u003eNo\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"6863\" data-end=\"6883\" data-col-size=\"sm\"\u003eYes (established)\u003c\/td\u003e\n\u003ctd data-start=\"6883\" data-end=\"6908\" data-col-size=\"sm\"\u003eProcedure-heavy risks\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr data-start=\"6910\" data-end=\"6913\"\u003e\n\u003ch2 data-start=\"6915\" data-end=\"6941\"\u003e7. Regulatory Landscape\u003c\/h2\u003e\n\u003cul data-start=\"6943\" data-end=\"7135\"\u003e\n\u003cli data-start=\"6943\" data-end=\"6980\"\u003e\n\u003cp data-start=\"6945\" data-end=\"6980\"\u003e\u003cstrong data-start=\"6945\" data-end=\"6961\"\u003eNot approved\u003c\/strong\u003e by FDA\/EMA\/PMDA.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"6981\" data-end=\"7045\"\u003e\n\u003cp data-start=\"6983\" data-end=\"7045\"\u003eNo registered IND-stage clinical program publicly available.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"7046\" data-end=\"7135\"\u003e\n\u003cp data-start=\"7048\" data-end=\"7135\"\u003eAny consumer sale is \u003cstrong data-start=\"7069\" data-end=\"7097\"\u003eresearch-chemical market\u003c\/strong\u003e; identity and purity are not assured.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-start=\"7137\" data-end=\"7140\"\u003e\n\u003ch2 data-start=\"7142\" data-end=\"7182\"\u003e8. Practical Take \u0026amp; Future Directions\u003c\/h2\u003e\n\u003cul data-start=\"7184\" data-end=\"7892\"\u003e\n\u003cli data-start=\"7184\" data-end=\"7368\"\u003e\n\u003cp data-start=\"7186\" data-end=\"7368\"\u003e\u003cstrong data-start=\"7186\" data-end=\"7213\"\u003eDo not self-experiment.\u003c\/strong\u003e Priorities are \u003cstrong data-start=\"7229\" data-end=\"7247\"\u003eGLP toxicology\u003c\/strong\u003e, \u003cstrong data-start=\"7249\" data-end=\"7287\"\u003egenotoxicity\/phototoxicity screens\u003c\/strong\u003e, cardiovascular safety, and \u003cstrong data-start=\"7316\" data-end=\"7342\"\u003efirst-in-human SAD\/MAD\u003c\/strong\u003e before any patient use.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"7369\" data-end=\"7719\"\u003e\n\u003cp data-start=\"7371\" data-end=\"7396\"\u003e\u003cstrong data-start=\"7371\" data-end=\"7394\"\u003eTrial design ideas:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul data-start=\"7399\" data-end=\"7719\"\u003e\n\u003cli data-start=\"7399\" data-end=\"7567\"\u003e\n\u003cp data-start=\"7401\" data-end=\"7567\"\u003e\u003cstrong data-start=\"7401\" data-end=\"7413\"\u003ePhase 1:\u003c\/strong\u003e PK\/PD with \u003cstrong data-start=\"7425\" data-end=\"7433\"\u003eqEEG\u003c\/strong\u003e, \u003cstrong data-start=\"7435\" data-end=\"7449\"\u003eoculomotor\u003c\/strong\u003e and \u003cstrong data-start=\"7454\" data-end=\"7471\"\u003emotor battery\u003c\/strong\u003e, \u003cstrong data-start=\"7473\" data-end=\"7501\"\u003emitochondrial biomarkers\u003c\/strong\u003e (acyl-carnitines), and \u003cstrong data-start=\"7525\" data-end=\"7549\"\u003eretinal\/striatal MRI\u003c\/strong\u003e safety markers.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"7570\" data-end=\"7719\"\u003e\n\u003cp data-start=\"7572\" data-end=\"7719\"\u003e\u003cstrong data-start=\"7572\" data-end=\"7607\"\u003ePhase 2a (PD or prodromal RBD):\u003c\/strong\u003e \u003cstrong data-start=\"7608\" data-end=\"7621\"\u003eDAT-SPECT\u003c\/strong\u003e, \u003cstrong data-start=\"7623\" data-end=\"7636\"\u003eMDS-UPDRS\u003c\/strong\u003e, \u003cstrong data-start=\"7638\" data-end=\"7664\"\u003egait\/typing kinematics\u003c\/strong\u003e, and \u003cstrong data-start=\"7670\" data-end=\"7691\"\u003einflammatory\/BDNF\u003c\/strong\u003e panels; exclude MAOI use.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"7720\" data-end=\"7892\"\u003e\n\u003cp data-start=\"7722\" data-end=\"7892\"\u003e\u003cstrong data-start=\"7722\" data-end=\"7736\"\u003eChemistry:\u003c\/strong\u003e Optimize \u003cstrong data-start=\"7746\" data-end=\"7764\"\u003ephotostability\u003c\/strong\u003e, \u003cstrong data-start=\"7766\" data-end=\"7781\"\u003eselectivity\u003c\/strong\u003e, and \u003cstrong data-start=\"7787\" data-end=\"7812\"\u003emitochondrial-sparing\u003c\/strong\u003e while retaining dopaminergic trophism; explore \u003cstrong data-start=\"7860\" data-end=\"7872\"\u003eprodrugs\u003c\/strong\u003e with CNS targeting.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-start=\"7894\" data-end=\"7897\"\u003e\n\u003ch3 data-start=\"7899\" data-end=\"7922\"\u003eSelected References\u003c\/h3\u003e\n\u003cul data-start=\"7924\" data-end=\"8613\"\u003e\n\u003cli data-start=\"7924\" data-end=\"8045\"\u003e\n\u003cp data-start=\"7926\" data-end=\"8045\"\u003e\u003cem data-start=\"7926\" data-end=\"7977\"\u003eJournal of Neurochemistry; Molecular Neurobiology\u003c\/em\u003e — Dopaminergic differentiation and neurite outgrowth under 9-MBC.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"8046\" data-end=\"8141\"\u003e\n\u003cp data-start=\"8048\" data-end=\"8141\"\u003e\u003cem data-start=\"8048\" data-end=\"8083\"\u003eNeuropharmacology; Brain Research\u003c\/em\u003e — Protection in \u003cstrong data-start=\"8100\" data-end=\"8115\"\u003eMPTP\/6-OHDA\u003c\/strong\u003e models; motor outcomes.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"8142\" data-end=\"8262\"\u003e\n\u003cp data-start=\"8144\" data-end=\"8262\"\u003e\u003cem data-start=\"8144\" data-end=\"8193\"\u003eRedox Biology; Journal of Neuroscience Research\u003c\/em\u003e — Mitochondrial function, \u003cstrong data-start=\"8220\" data-end=\"8230\"\u003ePGC-1α\u003c\/strong\u003e signaling, and mtROS effects.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"8263\" data-end=\"8358\"\u003e\n\u003cp data-start=\"8265\" data-end=\"8358\"\u003e\u003cem data-start=\"8265\" data-end=\"8301\"\u003eGlia; Journal of Neuroinflammation\u003c\/em\u003e — Microglial phenotype shifts and cytokine modulation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"8359\" data-end=\"8454\"\u003e\n\u003cp data-start=\"8361\" data-end=\"8454\"\u003e\u003cem data-start=\"8361\" data-end=\"8409\"\u003eHippocampus; Neurobiology of Learning \u0026amp; Memory\u003c\/em\u003e — Adult neurogenesis and memory behaviors.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"8455\" data-end=\"8511\"\u003e\n\u003cp data-start=\"8457\" data-end=\"8511\"\u003e\u003cem data-start=\"8457\" data-end=\"8480\"\u003eSynapse; Neuroscience\u003c\/em\u003e — Synaptic proteins and LTP.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"8512\" data-end=\"8613\"\u003e\n\u003cp data-start=\"8514\" data-end=\"8613\"\u003e\u003cem data-start=\"8514\" data-end=\"8568\"\u003eExperimental Neurology; Neurochemistry International\u003c\/em\u003e — Anti-excitotoxic and antioxidant defenses.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Mijn winkel","offers":[{"title":"Default Title","offer_id":52684862095698,"sku":"10","price":80.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1048\/0956\/2450\/files\/9-MBC_25mg.png?v=1770834916","url":"https:\/\/sciencepeptideslab.com\/products\/9-mbc-60x25mg","provider":"Science Peptides Lab","version":"1.0","type":"link"}