{"product_id":"ac-262-10x60mg","title":"AC-262 100x10mg","description":"\u003cp\u003e\u003cstrong\u003e\u003cspan\u003e\u003cstrong data-end=\"392\" data-start=\"377\"\u003e\u003cspan style=\"color: rgb(255, 42, 0);\"\u003e                                                  \u003cspan style=\"text-decoration: underline;\"\u003eNOT \u003c\/span\u003e\u003c\/span\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cspan style=\"text-decoration: underline; color: rgb(255, 42, 0);\"\u003eFOR HUMAN CONSUMPTION\u003cmeta charset=\"UTF-8\"\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-start=\"163\" data-end=\"629\"\u003e\u003cstrong\u003eAC-262 \u003c\/strong\u003eis an oral, non-steroidal \u003cstrong data-start=\"233\" data-end=\"281\"\u003eselective androgen receptor modulator (SARM)\u003c\/strong\u003e discovered in the early Acadia\/industry SARM programs. It binds the \u003cstrong data-start=\"350\" data-end=\"376\"\u003eandrogen receptor (AR)\u003c\/strong\u003e and drives \u003cstrong data-start=\"388\" data-end=\"405\"\u003eARE-regulated\u003c\/strong\u003e transcription with a \u003cstrong data-start=\"427\" data-end=\"466\"\u003emuscle\/bone-biased anabolic profile\u003c\/strong\u003e and comparatively \u003cstrong data-start=\"485\" data-end=\"519\"\u003eless prostate\/skin stimulation\u003c\/strong\u003e than testosterone. AC-262,536 is \u003cstrong data-start=\"553\" data-end=\"577\"\u003enot FDA\/EMA-approved\u003c\/strong\u003e and is \u003cstrong data-start=\"585\" data-end=\"607\"\u003eprohibited by WADA\u003c\/strong\u003e as an anabolic agent.\u003c\/p\u003e\n\u003chr data-start=\"631\" data-end=\"634\"\u003e\n\u003ch3 data-start=\"636\" data-end=\"697\"\u003eAdditional Benefits of AC-262,536 Now Under Investigation\u003c\/h3\u003e\n\u003cdiv class=\"_tableContainer_1rjym_1\"\u003e\n\u003cdiv class=\"_tableWrapper_1rjym_13 group flex w-fit flex-col-reverse\" tabindex=\"-1\"\u003e\n\u003ctable data-start=\"699\" data-end=\"2733\" class=\"w-fit min-w-(--thread-content-width)\"\u003e\n\u003cthead data-start=\"699\" data-end=\"727\"\u003e\n\u003ctr data-start=\"699\" data-end=\"727\"\u003e\n\u003cth data-start=\"699\" data-end=\"709\" data-col-size=\"md\"\u003eBenefit\u003c\/th\u003e\n\u003cth data-start=\"709\" data-end=\"727\" data-col-size=\"xl\"\u003eKey take-aways\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody data-start=\"738\" data-end=\"2733\"\u003e\n\u003ctr data-start=\"738\" data-end=\"1043\"\u003e\n\u003ctd data-start=\"738\" data-end=\"790\" data-col-size=\"md\"\u003e\u003cstrong data-start=\"740\" data-end=\"789\"\u003e1 Anabolic effect with partial-agonist safety\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"790\" data-end=\"1043\" data-col-size=\"xl\"\u003ePreclinical studies show \u003cstrong data-start=\"817\" data-end=\"860\"\u003elean-mass gain and myofiber hypertrophy\u003c\/strong\u003e with \u003cstrong data-start=\"866\" data-end=\"901\"\u003eattenuated prostate stimulation\u003c\/strong\u003e versus testosterone—consistent with \u003cstrong data-start=\"938\" data-end=\"960\"\u003epartial AR agonism\u003c\/strong\u003e and co-activator selectivity. \u0026lt;br\/\u0026gt;\u0026lt;em\u0026gt;Journal of Medicinal Chemistry; JPET\u0026lt;\/em\u0026gt;\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"1044\" data-end=\"1245\"\u003e\n\u003ctd data-start=\"1044\" data-end=\"1072\" data-col-size=\"md\"\u003e\u003cstrong data-start=\"1046\" data-end=\"1071\"\u003e2 Functional strength\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"1072\" data-end=\"1245\" data-col-size=\"xl\"\u003eRodent\/bench models report \u003cstrong data-start=\"1101\" data-end=\"1147\"\u003eincreased specific force and grip strength\u003c\/strong\u003e, aligning molecular anabolism with \u003cstrong data-start=\"1183\" data-end=\"1198\"\u003eperformance\u003c\/strong\u003e endpoints. \u0026lt;br\/\u0026gt;\u0026lt;em\u0026gt;FASEB Journal; MSSE\u0026lt;\/em\u0026gt;\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"1246\" data-end=\"1531\"\u003e\n\u003ctd data-start=\"1246\" data-end=\"1267\" data-col-size=\"md\"\u003e\u003cstrong data-start=\"1248\" data-end=\"1266\"\u003e3 Bone support\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"1267\" data-end=\"1531\" data-col-size=\"xl\"\u003eIn osteopenic models, SARMs in this chemical class \u003cstrong data-start=\"1320\" data-end=\"1333\"\u003eraise BMD\u003c\/strong\u003e, improve \u003cstrong data-start=\"1343\" data-end=\"1370\"\u003etrabecular architecture\u003c\/strong\u003e, and enhance \u003cstrong data-start=\"1384\" data-end=\"1413\"\u003ethree-point bend strength\u003c\/strong\u003e with minimal androgenic effects—AC-262 follows this trend. \u0026lt;br\/\u0026gt;\u0026lt;em\u0026gt;Journal of Bone and Mineral Research; Bone\u0026lt;\/em\u0026gt;\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"1532\" data-end=\"1759\"\u003e\n\u003ctd data-start=\"1532\" data-end=\"1566\" data-col-size=\"md\"\u003e\u003cstrong data-start=\"1534\" data-end=\"1565\"\u003e4 Anti-catabolic protection\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"1566\" data-end=\"1759\" data-col-size=\"xl\"\u003eUnder \u003cstrong data-start=\"1574\" data-end=\"1612\"\u003edisuse, glucocorticoid, or illness\u003c\/strong\u003e stress, AC-262–class signaling \u003cstrong data-start=\"1644\" data-end=\"1683\"\u003edown-shifts atrogenes (MAFbx\/MuRF1)\u003c\/strong\u003e and \u003cstrong data-start=\"1688\" data-end=\"1705\"\u003epreserves CSA\u003c\/strong\u003e. \u0026lt;br\/\u0026gt;\u0026lt;em\u0026gt;AJP–Endocrinology; Endocrine Reviews\u0026lt;\/em\u0026gt;\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"1760\" data-end=\"1968\"\u003e\n\u003ctd data-start=\"1760\" data-end=\"1817\" data-col-size=\"md\"\u003e\u003cstrong data-start=\"1762\" data-end=\"1816\"\u003e5 Lower sebaceous\/prostate drive (vs testosterone)\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"1817\" data-end=\"1968\" data-col-size=\"xl\"\u003eLack of \u003cstrong data-start=\"1827\" data-end=\"1862\"\u003e5-α reduction and aromatization\u003c\/strong\u003e helps limit \u003cstrong data-start=\"1875\" data-end=\"1894\"\u003eDHT\/E2-mediated\u003c\/strong\u003e side effects per mg anabolic effect. \u0026lt;br\/\u0026gt;\u0026lt;em\u0026gt;J Pharmacol Exp Ther\u0026lt;\/em\u0026gt;\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"1969\" data-end=\"2151\"\u003e\n\u003ctd data-start=\"1969\" data-end=\"1994\" data-col-size=\"md\"\u003e\u003cstrong data-start=\"1971\" data-end=\"1993\"\u003e6 Oral convenience\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"1994\" data-end=\"2151\" data-col-size=\"xl\"\u003eIntended \u003cstrong data-start=\"2005\" data-end=\"2019\"\u003eonce-daily\u003c\/strong\u003e oral dosing improves adherence in research settings compared with injectables. \u0026lt;br\/\u0026gt;\u0026lt;em\u0026gt;Clinical Pharmacology \u0026amp; Therapeutics\u0026lt;\/em\u0026gt;\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"2152\" data-end=\"2343\"\u003e\n\u003ctd data-start=\"2152\" data-end=\"2174\" data-col-size=\"md\"\u003e\u003cstrong data-start=\"2154\" data-end=\"2173\"\u003e7 Rehab synergy\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"2174\" data-end=\"2343\" data-col-size=\"xl\"\u003e\n\u003cstrong data-start=\"2176\" data-end=\"2188\"\u003eAdditive\u003c\/strong\u003e improvements when paired with \u003cstrong data-start=\"2219\" data-end=\"2254\"\u003eprogressive resistance training\u003c\/strong\u003e and adequate protein intake (preclinical → feasibility). \u0026lt;br\/\u0026gt;\u0026lt;em\u0026gt;Sports Medicine\u0026lt;\/em\u0026gt;\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"2344\" data-end=\"2539\"\u003e\n\u003ctd data-start=\"2344\" data-end=\"2378\" data-col-size=\"md\"\u003e\u003cstrong data-start=\"2346\" data-end=\"2377\"\u003e8 Hematologic tone (modest)\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"2378\" data-end=\"2539\" data-col-size=\"xl\"\u003eAR activation may \u003cstrong data-start=\"2398\" data-end=\"2438\"\u003eslightly raise hemoglobin\/hematocrit\u003c\/strong\u003e below testosterone’s magnitude—monitor in at-risk individuals. \u0026lt;br\/\u0026gt;\u0026lt;em\u0026gt;Hematology; Andrology\u0026lt;\/em\u0026gt;\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"2540\" data-end=\"2733\"\u003e\n\u003ctd data-start=\"2540\" data-end=\"2573\" data-col-size=\"md\"\u003e\u003cstrong data-start=\"2542\" data-end=\"2572\"\u003e9 Doping-control relevance\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"2573\" data-end=\"2733\" data-col-size=\"xl\"\u003e\n\u003cstrong data-start=\"2575\" data-end=\"2600\"\u003eLong-term metabolites\u003c\/strong\u003e enable \u003cstrong data-start=\"2608\" data-end=\"2632\"\u003eweeks-long detection\u003c\/strong\u003e; positives and supplement contaminations have been reported. \u0026lt;br\/\u0026gt;\u0026lt;em\u0026gt;Drug Testing \u0026amp; Analysis\u0026lt;\/em\u0026gt;\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr data-start=\"2735\" data-end=\"2738\"\u003e\n\u003ch2 data-start=\"2740\" data-end=\"2775\"\u003e2. Molecular Mechanism of Action\u003c\/h2\u003e\n\u003ch3 data-start=\"2777\" data-end=\"2812\"\u003e2.1 Receptor Pharmacodynamics\u003c\/h3\u003e\n\u003cp data-start=\"2813\" data-end=\"3120\"\u003eAC-262,536 binds \u003cstrong data-start=\"2830\" data-end=\"2836\"\u003eAR\u003c\/strong\u003e → nuclear translocation → \u003cstrong data-start=\"2863\" data-end=\"2870\"\u003eARE\u003c\/strong\u003e transcription. In skeletal muscle it \u003cstrong data-start=\"2908\" data-end=\"2940\"\u003eup-regulates mTOR\/S6K\/4E-BP1\u003c\/strong\u003e and local \u003cstrong data-start=\"2951\" data-end=\"2960\"\u003eIGF-1\u003c\/strong\u003e, while suppressing \u003cstrong data-start=\"2980\" data-end=\"3005\"\u003eFoxO-driven atrogenes\u003c\/strong\u003e. Partial agonism and ligand-specific \u003cstrong data-start=\"3043\" data-end=\"3071\"\u003eco-activator recruitment\u003c\/strong\u003e underlie \u003cstrong data-start=\"3081\" data-end=\"3103\"\u003etissue selectivity\u003c\/strong\u003e vs testosterone.\u003c\/p\u003e\n\u003ch3 data-start=\"3122\" data-end=\"3149\"\u003e2.2 Down-stream Biology\u003c\/h3\u003e\n\u003cdiv class=\"_tableContainer_1rjym_1\"\u003e\n\u003cdiv class=\"_tableWrapper_1rjym_13 group flex w-fit flex-col-reverse\" tabindex=\"-1\"\u003e\n\u003ctable data-start=\"3151\" data-end=\"3511\" class=\"w-fit min-w-(--thread-content-width)\"\u003e\n\u003cthead data-start=\"3151\" data-end=\"3193\"\u003e\n\u003ctr data-start=\"3151\" data-end=\"3193\"\u003e\n\u003cth data-start=\"3151\" data-end=\"3161\" data-col-size=\"sm\"\u003ePathway\u003c\/th\u003e\n\u003cth data-start=\"3161\" data-end=\"3182\" data-col-size=\"md\"\u003eFunctional outcome\u003c\/th\u003e\n\u003cth data-start=\"3182\" data-end=\"3193\" data-col-size=\"sm\"\u003eContext\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody data-start=\"3208\" data-end=\"3511\"\u003e\n\u003ctr data-start=\"3208\" data-end=\"3287\"\u003e\n\u003ctd data-start=\"3208\" data-end=\"3224\" data-col-size=\"sm\"\u003eAR → mTOR\/S6K\u003c\/td\u003e\n\u003ctd data-start=\"3224\" data-end=\"3268\" data-col-size=\"md\"\u003e↑ protein synthesis, myofiber hypertrophy\u003c\/td\u003e\n\u003ctd data-start=\"3268\" data-end=\"3287\" data-col-size=\"sm\"\u003eSkeletal muscle\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"3288\" data-end=\"3356\"\u003e\n\u003ctd data-start=\"3288\" data-end=\"3317\" data-col-size=\"sm\"\u003eAR ↔ Wnt\/β-catenin\/Osterix\u003c\/td\u003e\n\u003ctd data-start=\"3317\" data-end=\"3348\" data-col-size=\"md\"\u003e↑ osteoblast activity, ↑ BMD\u003c\/td\u003e\n\u003ctd data-start=\"3348\" data-end=\"3356\" data-col-size=\"sm\"\u003eBone\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"3357\" data-end=\"3431\"\u003e\n\u003ctd data-start=\"3357\" data-end=\"3378\" data-col-size=\"sm\"\u003e↓ FoxO\/MAFbx\/MuRF1\u003c\/td\u003e\n\u003ctd data-start=\"3378\" data-end=\"3411\" data-col-size=\"md\"\u003e↓ proteolysis (anti-catabolic)\u003c\/td\u003e\n\u003ctd data-start=\"3411\" data-end=\"3431\" data-col-size=\"sm\"\u003eCatabolic stress\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"3432\" data-end=\"3511\"\u003e\n\u003ctd data-start=\"3432\" data-end=\"3447\" data-col-size=\"sm\"\u003eHPG feedback\u003c\/td\u003e\n\u003ctd data-start=\"3447\" data-end=\"3485\" data-col-size=\"md\"\u003e↓ LH\/FSH\/testosterone (suppression)\u003c\/td\u003e\n\u003ctd data-start=\"3485\" data-end=\"3511\" data-col-size=\"sm\"\u003ePituitary–gonadal axis\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr data-start=\"3513\" data-end=\"3516\"\u003e\n\u003ch2 data-start=\"3518\" data-end=\"3540\"\u003e3. Pharmacokinetics\u003c\/h2\u003e\n\u003cul data-start=\"3542\" data-end=\"3910\"\u003e\n\u003cli data-start=\"3542\" data-end=\"3562\"\u003e\n\u003cp data-start=\"3544\" data-end=\"3562\"\u003e\u003cstrong data-start=\"3544\" data-end=\"3554\"\u003eRoute:\u003c\/strong\u003e Oral.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"3563\" data-end=\"3672\"\u003e\n\u003cp data-start=\"3565\" data-end=\"3672\"\u003e\u003cstrong data-start=\"3565\" data-end=\"3588\"\u003eHalf-life\/exposure:\u003c\/strong\u003e Human PK \u003cstrong data-start=\"3598\" data-end=\"3624\"\u003enot formally published\u003c\/strong\u003e; rodent PK supports \u003cstrong data-start=\"3645\" data-end=\"3659\"\u003eonce-daily\u003c\/strong\u003e paradigms.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"3673\" data-end=\"3795\"\u003e\n\u003cp data-start=\"3675\" data-end=\"3795\"\u003e\u003cstrong data-start=\"3675\" data-end=\"3690\"\u003eMetabolism:\u003c\/strong\u003e Hepatic oxidative\/conjugative clearance typical of non-steroidal SARMs; \u003cstrong data-start=\"3763\" data-end=\"3783\"\u003eno aromatase\/5-α\u003c\/strong\u003epathways.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"3796\" data-end=\"3910\"\u003e\n\u003cp data-start=\"3798\" data-end=\"3910\"\u003e\u003cstrong data-start=\"3798\" data-end=\"3812\"\u003eDetection:\u003c\/strong\u003e Anti-doping labs report \u003cstrong data-start=\"3837\" data-end=\"3873\"\u003eidentifiable urinary metabolites\u003c\/strong\u003e enabling \u003cstrong data-start=\"3883\" data-end=\"3909\"\u003elong detection windows\u003c\/strong\u003e.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-start=\"3912\" data-end=\"3915\"\u003e\n\u003ch2 data-start=\"3917\" data-end=\"3962\"\u003e4. Pre-clinical and Translational Evidence\u003c\/h2\u003e\n\u003ch3 data-start=\"3964\" data-end=\"3991\"\u003e4.1 Muscle \u0026amp; Function\u003c\/h3\u003e\n\u003cp data-start=\"3992\" data-end=\"4121\"\u003ePreclinical dosing increases \u003cstrong data-start=\"4021\" data-end=\"4034\"\u003elean mass\u003c\/strong\u003e, \u003cstrong data-start=\"4036\" data-end=\"4043\"\u003eCSA\u003c\/strong\u003e, and \u003cstrong data-start=\"4049\" data-end=\"4058\"\u003eforce\u003c\/strong\u003e with \u003cstrong data-start=\"4064\" data-end=\"4091\"\u003ereduced prostate weight\u003c\/strong\u003e versus testosterone controls.\u003c\/p\u003e\n\u003ch3 data-start=\"4123\" data-end=\"4137\"\u003e4.2 Bone\u003c\/h3\u003e\n\u003cp data-start=\"4138\" data-end=\"4284\"\u003eSARM-class effects include \u003cstrong data-start=\"4165\" data-end=\"4191\"\u003eBMD and strength gains\u003c\/strong\u003e in ovariectomized\/castrated models; AC-262,536 follows similar \u003cstrong data-start=\"4255\" data-end=\"4272\"\u003ebone-anabolic\u003c\/strong\u003e signatures.\u003c\/p\u003e\n\u003ch3 data-start=\"4286\" data-end=\"4306\"\u003e4.3 Human data\u003c\/h3\u003e\n\u003cp data-start=\"4307\" data-end=\"4482\"\u003e\u003cstrong data-start=\"4307\" data-end=\"4338\"\u003eNo completed pivotal trials\u003c\/strong\u003e publicly available. Most efficacy\/safety knowledge derives from \u003cstrong data-start=\"4403\" data-end=\"4421\"\u003eanimal studies\u003c\/strong\u003e, \u003cstrong data-start=\"4423\" data-end=\"4440\"\u003ein-vitro data\u003c\/strong\u003e, and \u003cstrong data-start=\"4446\" data-end=\"4470\"\u003eforensic anti-doping\u003c\/strong\u003e literature.\u003c\/p\u003e\n\u003cblockquote data-start=\"4484\" data-end=\"4640\"\u003e\n\u003cp data-start=\"4486\" data-end=\"4640\"\u003e\u003cstrong data-start=\"4486\" data-end=\"4512\"\u003eEvidence quality note:\u003c\/strong\u003e AC-262,536 has \u003cstrong data-start=\"4528\" data-end=\"4562\"\u003elimited, primarily preclinical\u003c\/strong\u003e evidence. Any human efficacy\/safety inferences are \u003cstrong data-start=\"4614\" data-end=\"4639\"\u003ehypothesis-generating\u003c\/strong\u003e.\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003chr data-start=\"4642\" data-end=\"4645\"\u003e\n\u003ch2 data-start=\"4647\" data-end=\"4680\"\u003e5. Emerging Clinical Interests\u003c\/h2\u003e\n\u003cdiv class=\"_tableContainer_1rjym_1\"\u003e\n\u003cdiv class=\"_tableWrapper_1rjym_13 group flex w-fit flex-col-reverse\" tabindex=\"-1\"\u003e\n\u003ctable data-start=\"4682\" data-end=\"5086\" class=\"w-fit min-w-(--thread-content-width)\"\u003e\n\u003cthead data-start=\"4682\" data-end=\"4720\"\u003e\n\u003ctr data-start=\"4682\" data-end=\"4720\"\u003e\n\u003cth data-start=\"4682\" data-end=\"4690\" data-col-size=\"sm\"\u003eField\u003c\/th\u003e\n\u003cth data-start=\"4690\" data-end=\"4702\" data-col-size=\"md\"\u003eRationale\u003c\/th\u003e\n\u003cth data-start=\"4702\" data-end=\"4720\" data-col-size=\"sm\"\u003eCurrent status\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody data-start=\"4735\" data-end=\"5086\"\u003e\n\u003ctr data-start=\"4735\" data-end=\"4834\"\u003e\n\u003ctd data-start=\"4735\" data-end=\"4760\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"4737\" data-end=\"4759\"\u003eSarcopenia\/frailty\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"md\" data-start=\"4760\" data-end=\"4799\"\u003eOral anabolic with selective profile\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-start=\"4799\" data-end=\"4834\"\u003ePreclinical\/early translational\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"4835\" data-end=\"4938\"\u003e\n\u003ctd data-start=\"4835\" data-end=\"4871\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"4837\" data-end=\"4870\"\u003eRehabilitation\/immobilization\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"md\" data-start=\"4871\" data-end=\"4910\"\u003ePreserve lean mass, improve function\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-start=\"4910\" data-end=\"4938\"\u003eConcept\/pilot frameworks\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"4939\" data-end=\"5015\"\u003e\n\u003ctd data-start=\"4939\" data-end=\"4956\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"4941\" data-end=\"4955\"\u003eOsteopenia\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"md\" data-start=\"4956\" data-end=\"5000\"\u003eBone-anabolic without high prostate drive\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-start=\"5000\" data-end=\"5015\"\u003ePreclinical\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"5016\" data-end=\"5086\"\u003e\n\u003ctd data-start=\"5016\" data-end=\"5031\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"5018\" data-end=\"5030\"\u003eCachexia\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"md\" data-start=\"5031\" data-end=\"5071\"\u003eAppetite-neutral anabolic alternative\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-start=\"5071\" data-end=\"5086\"\u003ePreclinical\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr data-start=\"5088\" data-end=\"5091\"\u003e\n\u003ch2 data-start=\"5093\" data-end=\"5122\"\u003e6. Safety and Tolerability\u003c\/h2\u003e\n\u003cul data-start=\"5124\" data-end=\"5826\"\u003e\n\u003cli data-start=\"5124\" data-end=\"5252\"\u003e\n\u003cp data-start=\"5126\" data-end=\"5252\"\u003e\u003cstrong data-start=\"5126\" data-end=\"5140\"\u003eEndocrine:\u003c\/strong\u003e \u003cstrong data-start=\"5141\" data-end=\"5175\"\u003eDose-dependent HPG suppression\u003c\/strong\u003e (↓ LH\/FSH\/testosterone) expected; recovery typically \u003cstrong data-start=\"5229\" data-end=\"5249\"\u003eweeks after stop\u003c\/strong\u003e.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"5253\" data-end=\"5340\"\u003e\n\u003cp data-start=\"5255\" data-end=\"5340\"\u003e\u003cstrong data-start=\"5255\" data-end=\"5266\"\u003eLipids:\u003c\/strong\u003e \u003cstrong data-start=\"5267\" data-end=\"5287\"\u003eHDL-C reductions\u003c\/strong\u003e (± ↑ LDL\/TG) common in SARM class—monitor CV risk.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"5341\" data-end=\"5506\"\u003e\n\u003cp data-start=\"5343\" data-end=\"5506\"\u003e\u003cstrong data-start=\"5343\" data-end=\"5355\"\u003eHepatic:\u003c\/strong\u003e Short-term SARM studies show small median ALT\/AST shifts, but \u003cstrong data-start=\"5418\" data-end=\"5438\"\u003ereal-world cases\u003c\/strong\u003e of liver injury have occurred with \u003cstrong data-start=\"5474\" data-end=\"5503\"\u003eunregulated SARM products\u003c\/strong\u003e.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"5507\" data-end=\"5566\"\u003e\n\u003cp data-start=\"5509\" data-end=\"5566\"\u003e\u003cstrong data-start=\"5509\" data-end=\"5516\"\u003eCV:\u003c\/strong\u003e No outcomes data; lipid shifts warrant caution.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"5567\" data-end=\"5650\"\u003e\n\u003cp data-start=\"5569\" data-end=\"5650\"\u003e\u003cstrong data-start=\"5569\" data-end=\"5586\"\u003eDermatologic:\u003c\/strong\u003e Possible \u003cstrong data-start=\"5596\" data-end=\"5613\"\u003eacne\/oiliness\u003c\/strong\u003e; \u003cstrong data-start=\"5615\" data-end=\"5632\"\u003ehair shedding\u003c\/strong\u003e in predisposed.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"5651\" data-end=\"5731\"\u003e\n\u003cp data-start=\"5653\" data-end=\"5731\"\u003e\u003cstrong data-start=\"5653\" data-end=\"5668\"\u003eNeuropsych:\u003c\/strong\u003e Occasional \u003cstrong data-start=\"5680\" data-end=\"5705\"\u003einsomnia\/irritability\u003c\/strong\u003e reported for the class.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"5732\" data-end=\"5826\"\u003e\n\u003cp data-start=\"5734\" data-end=\"5826\"\u003e\u003cstrong data-start=\"5734\" data-end=\"5756\"\u003eDrug interactions:\u003c\/strong\u003e Potential with \u003cstrong data-start=\"5772\" data-end=\"5790\"\u003ehepatic enzyme\u003c\/strong\u003e modulators; \u003cstrong data-start=\"5803\" data-end=\"5825\"\u003eavoid in pregnancy\u003c\/strong\u003e.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-start=\"5828\" data-end=\"5857\"\u003e\u003cstrong data-start=\"5828\" data-end=\"5857\"\u003eComparative safety matrix\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"_tableContainer_1rjym_1\"\u003e\n\u003cdiv class=\"_tableWrapper_1rjym_13 group flex w-fit flex-col-reverse\" tabindex=\"-1\"\u003e\n\u003ctable data-start=\"5859\" data-end=\"6254\" class=\"w-fit min-w-(--thread-content-width)\"\u003e\n\u003cthead data-start=\"5859\" data-end=\"5928\"\u003e\n\u003ctr data-start=\"5859\" data-end=\"5928\"\u003e\n\u003cth data-start=\"5859\" data-end=\"5869\" data-col-size=\"sm\"\u003eConcern\u003c\/th\u003e\n\u003cth data-start=\"5869\" data-end=\"5886\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"5871\" data-end=\"5885\"\u003eAC-262,536\u003c\/strong\u003e\u003c\/th\u003e\n\u003cth data-start=\"5886\" data-end=\"5912\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"5888\" data-end=\"5911\"\u003eEnobosarm (MK-2866)\u003c\/strong\u003e\u003c\/th\u003e\n\u003cth data-start=\"5912\" data-end=\"5928\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"5914\" data-end=\"5926\"\u003eLGD-4033\u003c\/strong\u003e\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody data-start=\"5947\" data-end=\"6254\"\u003e\n\u003ctr data-start=\"5947\" data-end=\"6021\"\u003e\n\u003ctd data-start=\"5947\" data-end=\"5964\" data-col-size=\"sm\"\u003eHuman evidence\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-start=\"5964\" data-end=\"5983\"\u003e\u003cstrong data-start=\"5966\" data-end=\"5982\"\u003eVery limited\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-start=\"5983\" data-end=\"6001\"\u003ePhase 2 signals\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-start=\"6001\" data-end=\"6021\"\u003eSmall RCT (21 d)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"6022\" data-end=\"6089\"\u003e\n\u003ctd data-start=\"6022\" data-end=\"6040\" data-col-size=\"sm\"\u003eHPG suppression\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-start=\"6040\" data-end=\"6066\"\u003e\u003cstrong data-start=\"6042\" data-end=\"6065\"\u003eModerate (expected)\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-start=\"6066\" data-end=\"6077\"\u003eModerate\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-start=\"6077\" data-end=\"6089\"\u003eModerate\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"6090\" data-end=\"6127\"\u003e\n\u003ctd data-start=\"6090\" data-end=\"6103\" data-col-size=\"sm\"\u003eHDL impact\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-start=\"6103\" data-end=\"6118\"\u003e\u003cstrong data-start=\"6105\" data-end=\"6117\"\u003eLikely ↓\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-start=\"6118\" data-end=\"6122\"\u003e↓\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-start=\"6122\" data-end=\"6127\"\u003e↓\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"6128\" data-end=\"6188\"\u003e\n\u003ctd data-start=\"6128\" data-end=\"6151\" data-col-size=\"sm\"\u003eProstate stimulation\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-start=\"6151\" data-end=\"6175\"\u003e\u003cstrong data-start=\"6153\" data-end=\"6174\"\u003eLow (preclinical)\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-start=\"6175\" data-end=\"6181\"\u003eLow\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-start=\"6181\" data-end=\"6188\"\u003eLow\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"6189\" data-end=\"6254\"\u003e\n\u003ctd data-start=\"6189\" data-end=\"6203\" data-col-size=\"sm\"\u003eOral dosing\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-start=\"6203\" data-end=\"6227\"\u003eOnce daily (intended)\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-start=\"6227\" data-end=\"6240\"\u003eOnce daily\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-start=\"6240\" data-end=\"6254\"\u003eOnce daily\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr data-start=\"6256\" data-end=\"6259\"\u003e\n\u003ch2 data-start=\"6261\" data-end=\"6287\"\u003e7. Regulatory Landscape\u003c\/h2\u003e\n\u003cul data-start=\"6289\" data-end=\"6517\"\u003e\n\u003cli data-start=\"6289\" data-end=\"6317\"\u003e\n\u003cp data-start=\"6291\" data-end=\"6317\"\u003e\u003cstrong data-start=\"6291\" data-end=\"6305\"\u003eApprovals:\u003c\/strong\u003e \u003cstrong data-start=\"6306\" data-end=\"6314\"\u003eNone\u003c\/strong\u003e.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"6318\" data-end=\"6418\"\u003e\n\u003cp data-start=\"6320\" data-end=\"6418\"\u003e\u003cstrong data-start=\"6320\" data-end=\"6330\"\u003eSport:\u003c\/strong\u003e \u003cstrong data-start=\"6331\" data-end=\"6350\"\u003eWADA-prohibited\u003c\/strong\u003e (S1 Anabolic Agents) at all times; strict liability for athletes.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"6419\" data-end=\"6517\"\u003e\n\u003cp data-start=\"6421\" data-end=\"6517\"\u003e\u003cstrong data-start=\"6421\" data-end=\"6432\"\u003eSupply:\u003c\/strong\u003e Often appears in \u003cstrong data-start=\"6450\" data-end=\"6471\"\u003eresearch-chemical\u003c\/strong\u003e markets; \u003cstrong data-start=\"6481\" data-end=\"6509\"\u003eadulteration\/mislabeling\u003c\/strong\u003e common.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-start=\"6519\" data-end=\"6522\"\u003e\n\u003ch2 data-start=\"6524\" data-end=\"6547\"\u003e8. Future Directions\u003c\/h2\u003e\n\u003cul data-start=\"6549\" data-end=\"7025\"\u003e\n\u003cli data-start=\"6549\" data-end=\"6648\"\u003e\n\u003cp data-start=\"6551\" data-end=\"6648\"\u003e\u003cstrong data-start=\"6551\" data-end=\"6575\"\u003eFirst-in-human PK\/PD\u003c\/strong\u003e with \u003cstrong data-start=\"6581\" data-end=\"6588\"\u003eGMP\u003c\/strong\u003e supply: define half-life, metabolites, exposure–response.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"6649\" data-end=\"6765\"\u003e\n\u003cp data-start=\"6651\" data-end=\"6765\"\u003e\u003cstrong data-start=\"6651\" data-end=\"6682\"\u003eHead-to-head vs other SARMs\u003c\/strong\u003e on \u003cstrong data-start=\"6686\" data-end=\"6715\"\u003eanabolic:androgenic ratio\u003c\/strong\u003e, \u003cstrong data-start=\"6717\" data-end=\"6737\"\u003elipid neutrality\u003c\/strong\u003e, and \u003cstrong data-start=\"6743\" data-end=\"6762\"\u003eHPG suppression\u003c\/strong\u003e.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"6766\" data-end=\"6841\"\u003e\n\u003cp data-start=\"6768\" data-end=\"6841\"\u003e\u003cstrong data-start=\"6768\" data-end=\"6788\"\u003eLong-term safety\u003c\/strong\u003e: lipids\/CV, hepatic, endocrine recovery, mood\/CNS.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"6842\" data-end=\"6948\"\u003e\n\u003cp data-start=\"6844\" data-end=\"6948\"\u003e\u003cstrong data-start=\"6844\" data-end=\"6871\"\u003eRehab\/sarcopenia trials\u003c\/strong\u003e coupled with \u003cstrong data-start=\"6885\" data-end=\"6921\"\u003estandardized resistance training\u003c\/strong\u003e and \u003cstrong data-start=\"6926\" data-end=\"6945\"\u003eprotein targets\u003c\/strong\u003e.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"6949\" data-end=\"7025\"\u003e\n\u003cp data-start=\"6951\" data-end=\"7025\"\u003e\u003cstrong data-start=\"6951\" data-end=\"6969\"\u003eDoping science\u003c\/strong\u003e: comprehensive \u003cstrong data-start=\"6985\" data-end=\"7002\"\u003emetabolite ID\u003c\/strong\u003e and detection windows.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-start=\"7027\" data-end=\"7030\"\u003e\n\u003ch3 data-start=\"7032\" data-end=\"7055\"\u003eSelected References\u003c\/h3\u003e\n\u003cul data-start=\"7057\" data-end=\"7802\"\u003e\n\u003cli data-start=\"7057\" data-end=\"7226\"\u003e\n\u003cp data-start=\"7059\" data-end=\"7226\"\u003e\u003cstrong data-start=\"7059\" data-end=\"7146\"\u003eJournal of Medicinal Chemistry; Journal of Pharmacology \u0026amp; Experimental Therapeutics\u003c\/strong\u003e — Discovery and pharmacology of non-steroidal SARMs including \u003cstrong data-start=\"7209\" data-end=\"7223\"\u003eAC-262,536\u003c\/strong\u003e.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"7227\" data-end=\"7359\"\u003e\n\u003cp data-start=\"7229\" data-end=\"7359\"\u003e\u003cstrong data-start=\"7229\" data-end=\"7292\"\u003eFASEB Journal; American Journal of Physiology–Endocrinology\u003c\/strong\u003e — SARM anti-catabolic signalling (mTOR up, FoxO\/atrogenes down).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"7360\" data-end=\"7481\"\u003e\n\u003cp data-start=\"7362\" data-end=\"7481\"\u003e\u003cstrong data-start=\"7362\" data-end=\"7408\"\u003eJournal of Bone and Mineral Research; Bone\u003c\/strong\u003e — SARM effects on BMD and biomechanical strength in osteopenic models.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"7482\" data-end=\"7556\"\u003e\n\u003cp data-start=\"7484\" data-end=\"7556\"\u003e\u003cstrong data-start=\"7484\" data-end=\"7524\"\u003eClinical Pharmacology \u0026amp; Therapeutics\u003c\/strong\u003e — Oral SARM PK\/PD principles.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"7557\" data-end=\"7662\"\u003e\n\u003cp data-start=\"7559\" data-end=\"7662\"\u003e\u003cstrong data-start=\"7559\" data-end=\"7586\"\u003eDrug Testing \u0026amp; Analysis\u003c\/strong\u003e — Identification of \u003cstrong data-start=\"7607\" data-end=\"7621\"\u003eAC-262,536\u003c\/strong\u003e metabolites and anti-doping detection.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"7663\" data-end=\"7802\"\u003e\n\u003cp data-start=\"7665\" data-end=\"7802\"\u003e\u003cstrong data-start=\"7665\" data-end=\"7717\"\u003eHepatology Communications; J Clin Transl Hepatol\u003c\/strong\u003e — Case reports of liver injury associated with unregulated SARM use (class context)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"Mijn winkel","offers":[{"title":"Default Title","offer_id":52684872712530,"sku":null,"price":55.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1048\/0956\/2450\/files\/AC-262_10mg.png?v=1770834984","url":"https:\/\/sciencepeptideslab.com\/products\/ac-262-10x60mg","provider":"Science Peptides Lab","version":"1.0","type":"link"}