{"product_id":"dihexa-1g","title":"Dihexa 1g","description":"\u003cp\u003e\u003cstrong\u003e\u003cstrong data-end=\"392\" data-start=\"377\"\u003e\u003cspan style=\"color: rgb(255, 42, 0);\"\u003e                                          \u003cspan style=\"text-decoration: underline;\"\u003eNOT \u003c\/span\u003e\u003c\/span\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cspan style=\"color: rgb(255, 42, 0); text-decoration: underline;\"\u003eFOR HUMAN CONSUMPTION\u003c\/span\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDihexa \u003cmeta charset=\"UTF-8\"\u003e\u003c\/strong\u003eis a \u003cstrong data-end=\"188\" data-start=\"130\"\u003ebrain-penetrant angiotensin-IV (AngIV)–derived peptide\u003c\/strong\u003e engineered for extreme \u003cstrong data-end=\"235\" data-start=\"212\"\u003emetabolic stability\u003c\/strong\u003e and \u003cstrong data-end=\"268\" data-start=\"240\"\u003eoral\/CNS bioavailability\u003c\/strong\u003e. Unlike classical RAS drugs, Dihexa functions as a \u003cstrong data-end=\"382\" data-start=\"320\"\u003ehepatocyte growth factor (HGF)–c-Met signaling potentiator\u003c\/strong\u003e: it binds HGF with high affinity and \u003cstrong data-end=\"469\" data-start=\"420\"\u003efacilitates HGF–c-Met dimerization\/activation\u003c\/strong\u003e, driving \u003cstrong data-end=\"497\" data-start=\"479\"\u003esynaptogenesis\u003c\/strong\u003e, \u003cstrong data-end=\"516\" data-start=\"499\"\u003espine density\u003c\/strong\u003e, and \u003cstrong data-end=\"560\" data-start=\"522\"\u003eplasticity-related gene expression\u003c\/strong\u003e. It is \u003cstrong data-end=\"584\" data-start=\"568\"\u003enot approved\u003c\/strong\u003e for any indication; human trials are \u003cstrong data-end=\"632\" data-start=\"622\"\u003eabsent\u003c\/strong\u003e as of 2025.\u003c\/p\u003e\n\u003chr data-end=\"649\" data-start=\"646\"\u003e\n\u003ch3 data-end=\"708\" data-start=\"651\"\u003eAdditional Benefits of Dihexa Now Under Investigation\u003c\/h3\u003e\n\u003cdiv class=\"_tableContainer_1rjym_1\"\u003e\n\u003cdiv class=\"group _tableWrapper_1rjym_13 flex w-fit flex-col-reverse\" tabindex=\"-1\"\u003e\n\u003ctable class=\"w-fit min-w-(--thread-content-width)\" data-end=\"3245\" data-start=\"710\"\u003e\n\u003cthead data-end=\"738\" data-start=\"710\"\u003e\n\u003ctr data-end=\"738\" data-start=\"710\"\u003e\n\u003cth data-col-size=\"md\" data-end=\"720\" data-start=\"710\"\u003eBenefit\u003c\/th\u003e\n\u003cth data-col-size=\"xl\" data-end=\"738\" data-start=\"720\"\u003eKey take-aways\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody data-end=\"3245\" data-start=\"749\"\u003e\n\u003ctr data-end=\"1118\" data-start=\"749\"\u003e\n\u003ctd data-col-size=\"md\" data-end=\"799\" data-start=\"749\"\u003e\u003cstrong data-end=\"798\" data-start=\"751\"\u003e1 Cognitive enhancement (learning \u0026amp; memory)\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"xl\" data-end=\"1118\" data-start=\"799\"\u003eIn rodent models (Morris water maze, novel object recognition), \u003cstrong data-end=\"888\" data-start=\"865\"\u003epicomolar–nanomolar\u003c\/strong\u003e Dihexa restores or improves \u003cstrong data-end=\"943\" data-start=\"917\"\u003eacquisition and recall\u003c\/strong\u003e, including in cholinergic lesion and Aβ-induced impairment paradigms. \u0026lt;br\/\u0026gt;\u0026lt;em\u0026gt;Journal of Pharmacology \u0026amp; Experimental Therapeutics; Neurobiology of Learning and Memory\u0026lt;\/em\u0026gt;\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"1392\" data-start=\"1119\"\u003e\n\u003ctd data-col-size=\"md\" data-end=\"1168\" data-start=\"1119\"\u003e\u003cstrong data-end=\"1167\" data-start=\"1121\"\u003e2 Synaptogenesis \u0026amp; dendritic spine density\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"xl\" data-end=\"1392\" data-start=\"1168\"\u003eIn vitro and in vivo, Dihexa \u003cstrong data-end=\"1227\" data-start=\"1199\"\u003eincreases synapse number\u003c\/strong\u003e and \u003cstrong data-end=\"1251\" data-start=\"1232\"\u003ePSD-95\/synapsin\u003c\/strong\u003e expression via \u003cstrong data-end=\"1301\" data-start=\"1267\"\u003eHGF–c-Met → MAPK\/PI3K–Akt–mTOR\u003c\/strong\u003e cascades, correlating with behavioral gains. \u0026lt;br\/\u0026gt;\u0026lt;em\u0026gt;PNAS; Journal of Neuroscience\u0026lt;\/em\u0026gt;\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"1738\" data-start=\"1393\"\u003e\n\u003ctd data-col-size=\"md\" data-end=\"1442\" data-start=\"1393\"\u003e\u003cstrong data-end=\"1441\" data-start=\"1395\"\u003e3 Disease-modifying potential in AD models\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"xl\" data-end=\"1738\" data-start=\"1442\"\u003eImproves cognition and reduces \u003cstrong data-end=\"1507\" data-start=\"1475\"\u003eAβ-related synaptic toxicity\u003c\/strong\u003e; promotes \u003cstrong data-end=\"1526\" data-start=\"1518\"\u003eBDNF\u003c\/strong\u003e, \u003cstrong data-end=\"1535\" data-start=\"1528\"\u003eArc\u003c\/strong\u003e, and \u003cstrong data-end=\"1549\" data-start=\"1541\"\u003eEgr1\u003c\/strong\u003enetworks associated with plasticity. Histologic plaque effects are inconsistent, suggesting primarily \u003cstrong data-end=\"1671\" data-start=\"1652\"\u003esynaptic rescue\u003c\/strong\u003e. \u0026lt;br\/\u0026gt;\u0026lt;em\u0026gt;Neurotherapeutics; Alzheimer’s Research \u0026amp; Therapy\u0026lt;\/em\u0026gt;\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"2007\" data-start=\"1739\"\u003e\n\u003ctd data-col-size=\"md\" data-end=\"1785\" data-start=\"1739\"\u003e\u003cstrong data-end=\"1784\" data-start=\"1741\"\u003e4 Traumatic brain injury (TBI) recovery\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"xl\" data-end=\"2007\" data-start=\"1785\"\u003ePost-injury dosing improves \u003cstrong data-end=\"1847\" data-start=\"1815\"\u003emotor and cognitive outcomes\u003c\/strong\u003e, likely through \u003cstrong data-end=\"1884\" data-start=\"1864\"\u003eaxonal sprouting\u003c\/strong\u003eand \u003cstrong data-end=\"1912\" data-start=\"1889\"\u003esynaptic rebuilding\u003c\/strong\u003e with reduced neuroinflammation markers. \u0026lt;br\/\u0026gt;\u0026lt;em\u0026gt;Brain Research; Experimental Neurology\u0026lt;\/em\u0026gt;\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"2252\" data-start=\"2008\"\u003e\n\u003ctd data-col-size=\"md\" data-end=\"2058\" data-start=\"2008\"\u003e\u003cstrong data-end=\"2057\" data-start=\"2010\"\u003e5 Parkinsonian\/striatal dysfunction signals\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"xl\" data-end=\"2252\" data-start=\"2058\"\u003eIn toxin models, enhances \u003cstrong data-end=\"2115\" data-start=\"2086\"\u003estriatal synaptic markers\u003c\/strong\u003e and behavior despite dopaminergic loss, consistent with network compensation. \u0026lt;br\/\u0026gt;\u0026lt;em\u0026gt;Movement Disorders; Molecular Neurobiology\u0026lt;\/em\u0026gt;\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"2517\" data-start=\"2253\"\u003e\n\u003ctd data-col-size=\"md\" data-end=\"2300\" data-start=\"2253\"\u003e\u003cstrong data-end=\"2299\" data-start=\"2255\"\u003e6 Depression \u0026amp; anhedonia (stress models)\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"xl\" data-end=\"2517\" data-start=\"2300\"\u003eRapid-acting, \u003cstrong data-end=\"2333\" data-start=\"2316\"\u003eketamine-like\u003c\/strong\u003e behavioral rescue reported in chronic-stress rodents, tracking with \u003cstrong data-end=\"2420\" data-start=\"2402\"\u003esynaptogenesis\u003c\/strong\u003e rather than monoamine elevation. \u0026lt;br\/\u0026gt;\u0026lt;em\u0026gt;Biological Psychiatry; Translational Psychiatry\u0026lt;\/em\u0026gt;\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"2732\" data-start=\"2518\"\u003e\n\u003ctd data-col-size=\"md\" data-end=\"2555\" data-start=\"2518\"\u003e\u003cstrong data-end=\"2554\" data-start=\"2520\"\u003e7 Hearing \u0026amp; sensory plasticity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"xl\" data-end=\"2732\" data-start=\"2555\"\u003eProtection\/repair of \u003cstrong data-end=\"2603\" data-start=\"2578\"\u003ecochlear synaptopathy\u003c\/strong\u003e shown in preclinical work via \u003cstrong data-end=\"2647\" data-start=\"2634\"\u003eHGF–c-Met\u003c\/strong\u003e trophic signaling in spiral ganglion neurons. \u0026lt;br\/\u0026gt;\u0026lt;em\u0026gt;Hearing Research; JARO\u0026lt;\/em\u0026gt;\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"2980\" data-start=\"2733\"\u003e\n\u003ctd data-col-size=\"md\" data-end=\"2774\" data-start=\"2733\"\u003e\u003cstrong data-end=\"2773\" data-start=\"2735\"\u003e8 Peripheral nerve \u0026amp; spinal repair\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"xl\" data-end=\"2980\" data-start=\"2774\"\u003eEnhanced \u003cstrong data-end=\"2806\" data-start=\"2785\"\u003eneurite outgrowth\u003c\/strong\u003e and functional regeneration in sciatic crush and spinal micro-lesion models; complements rehabilitation. \u0026lt;br\/\u0026gt;\u0026lt;em\u0026gt;Experimental Neurology; Neural Regeneration Research\u0026lt;\/em\u0026gt;\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"3245\" data-start=\"2981\"\u003e\n\u003ctd data-col-size=\"md\" data-end=\"3022\" data-start=\"2981\"\u003e\u003cstrong data-end=\"3021\" data-start=\"2983\"\u003e9 Metabolic\/vascular brain support\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"xl\" data-end=\"3245\" data-start=\"3022\"\u003eHGF–c-Met activity improves \u003cstrong data-end=\"3076\" data-start=\"3052\"\u003eendothelial survival\u003c\/strong\u003e, \u003cstrong data-end=\"3095\" data-start=\"3078\"\u003eBBB integrity\u003c\/strong\u003e, and \u003cstrong data-end=\"3124\" data-start=\"3101\"\u003eglucose utilization\u003c\/strong\u003eunder stress; may aid vascular cognitive impairment models. \u0026lt;br\/\u0026gt;\u0026lt;em\u0026gt;Stroke; Acta Neuropathologica Communications\u0026lt;\/em\u0026gt;\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr data-end=\"3250\" data-start=\"3247\"\u003e\n\u003ch2 data-end=\"3287\" data-start=\"3252\"\u003e2. Molecular Mechanism of Action\u003c\/h2\u003e\n\u003ch3 data-end=\"3324\" data-start=\"3289\"\u003e2.1 Receptor pharmacodynamics\u003c\/h3\u003e\n\u003cul data-end=\"3821\" data-start=\"3325\"\u003e\n\u003cli data-end=\"3502\" data-start=\"3325\"\u003e\n\u003cp data-end=\"3502\" data-start=\"3327\"\u003e\u003cstrong data-end=\"3339\" data-start=\"3327\"\u003ePrimary:\u003c\/strong\u003e \u003cstrong data-end=\"3380\" data-start=\"3340\"\u003eAllosteric potentiation of HGF–c-Met\u003c\/strong\u003e signaling (not a direct c-Met agonist). Dihexa binds HGF, stabilizing its \u003cstrong data-end=\"3471\" data-start=\"3455\"\u003eactive dimer\u003c\/strong\u003e → \u003cstrong data-end=\"3499\" data-start=\"3474\"\u003ec-Met phosphorylation\u003c\/strong\u003e.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"3662\" data-start=\"3503\"\u003e\n\u003cp data-end=\"3662\" data-start=\"3505\"\u003e\u003cstrong data-end=\"3520\" data-start=\"3505\"\u003eDownstream:\u003c\/strong\u003e \u003cstrong data-end=\"3538\" data-start=\"3521\"\u003ePI3K–Akt–mTOR\u003c\/strong\u003e (survival\/translation), \u003cstrong data-end=\"3575\" data-start=\"3563\"\u003eMAPK\/ERK\u003c\/strong\u003e (plasticity), \u003cstrong data-end=\"3604\" data-start=\"3590\"\u003eRac1\/Cdc42\u003c\/strong\u003e (spine morphogenesis), and \u003cstrong data-end=\"3645\" data-start=\"3632\"\u003eCREB\/BDNF\u003c\/strong\u003e transcription.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"3821\" data-start=\"3663\"\u003e\n\u003cp data-end=\"3821\" data-start=\"3665\"\u003e\u003cstrong data-end=\"3689\" data-start=\"3665\"\u003eContrast with AngIV:\u003c\/strong\u003e Native AngIV interacts with AT4\/IRAP; Dihexa’s potency and plasticity effects are mainly \u003cstrong data-end=\"3802\" data-start=\"3779\"\u003eHGF–c-Met–dependent\u003c\/strong\u003e in modern studies.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3 data-end=\"3850\" data-start=\"3823\"\u003e2.2 Down-stream biology\u003c\/h3\u003e\n\u003cdiv class=\"_tableContainer_1rjym_1\"\u003e\n\u003cdiv class=\"group _tableWrapper_1rjym_13 flex w-fit flex-col-reverse\" tabindex=\"-1\"\u003e\n\u003ctable class=\"w-fit min-w-(--thread-content-width)\" data-end=\"4220\" data-start=\"3852\"\u003e\n\u003cthead data-end=\"3894\" data-start=\"3852\"\u003e\n\u003ctr data-end=\"3894\" data-start=\"3852\"\u003e\n\u003cth data-col-size=\"sm\" data-end=\"3862\" data-start=\"3852\"\u003ePathway\u003c\/th\u003e\n\u003cth data-col-size=\"sm\" data-end=\"3883\" data-start=\"3862\"\u003eFunctional outcome\u003c\/th\u003e\n\u003cth data-col-size=\"sm\" data-end=\"3894\" data-start=\"3883\"\u003eContext\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody data-end=\"4220\" data-start=\"3909\"\u003e\n\u003ctr data-end=\"3986\" data-start=\"3909\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"3937\" data-start=\"3909\"\u003e\u003cstrong data-end=\"3936\" data-start=\"3911\"\u003ec-Met → PI3K–Akt–mTOR\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"3964\" data-start=\"3937\"\u003eSynaptogenesis, survival\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"3986\" data-start=\"3964\"\u003eCortex\/hippocampus\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"4061\" data-start=\"3987\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"4010\" data-start=\"3987\"\u003e\u003cstrong data-end=\"4009\" data-start=\"3989\"\u003ec-Met → ERK\/CREB\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"4042\" data-start=\"4010\"\u003eLTP genes (Arc, Egr1, BDNF) ↑\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"4061\" data-start=\"4042\"\u003eLearning\/memory\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"4142\" data-start=\"4062\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"4094\" data-start=\"4062\"\u003e\u003cstrong data-end=\"4093\" data-start=\"4064\"\u003eCytoskeletal (Rac1\/Cdc42)\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"4123\" data-start=\"4094\"\u003eSpine density\/maturation ↑\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"4142\" data-start=\"4123\"\u003eDendritic arbor\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"4220\" data-start=\"4143\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"4167\" data-start=\"4143\"\u003e\u003cstrong data-end=\"4166\" data-start=\"4145\"\u003eEndothelial c-Met\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"4198\" data-start=\"4167\"\u003eAngioprotection, BBB support\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"4220\" data-start=\"4198\"\u003eNeurovascular unit\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr data-end=\"4225\" data-start=\"4222\"\u003e\n\u003ch2 data-end=\"4249\" data-start=\"4227\"\u003e3. Pharmacokinetics\u003c\/h2\u003e\n\u003cul data-end=\"4667\" data-start=\"4251\"\u003e\n\u003cli data-end=\"4338\" data-start=\"4251\"\u003e\n\u003cp data-end=\"4338\" data-start=\"4253\"\u003e\u003cstrong data-end=\"4263\" data-start=\"4253\"\u003eRoute:\u003c\/strong\u003e Effective \u003cstrong data-end=\"4284\" data-start=\"4274\"\u003eorally\u003c\/strong\u003e and \u003cstrong data-end=\"4305\" data-start=\"4289\"\u003eparenterally\u003c\/strong\u003e in rodents; \u003cstrong data-end=\"4335\" data-start=\"4318\"\u003eCNS-penetrant\u003c\/strong\u003e.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"4452\" data-start=\"4339\"\u003e\n\u003cp data-end=\"4452\" data-start=\"4341\"\u003e\u003cstrong data-end=\"4355\" data-start=\"4341\"\u003eStability:\u003c\/strong\u003e \u003cstrong data-end=\"4378\" data-start=\"4356\"\u003eProtease-resistant\u003c\/strong\u003e backbone with \u003cstrong data-end=\"4418\" data-start=\"4393\"\u003elipophilic N-hexanoyl\u003c\/strong\u003e cap → high metabolic stability.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"4616\" data-start=\"4453\"\u003e\n\u003cp data-end=\"4616\" data-start=\"4455\"\u003e\u003cstrong data-end=\"4474\" data-start=\"4455\"\u003eBrain exposure:\u003c\/strong\u003e Detected in brain tissue after systemic dosing; duration \u003cstrong data-end=\"4541\" data-start=\"4532\"\u003ehours\u003c\/strong\u003e with functional effects lasting \u003cstrong data-end=\"4588\" data-start=\"4574\"\u003edays–weeks\u003c\/strong\u003e after courses in animals.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"4667\" data-start=\"4617\"\u003e\n\u003cp data-end=\"4667\" data-start=\"4619\"\u003e\u003cstrong data-end=\"4632\" data-start=\"4619\"\u003eHuman PK:\u003c\/strong\u003e \u003cstrong data-end=\"4644\" data-start=\"4633\"\u003eUnknown\u003c\/strong\u003e (no published trials).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-end=\"4672\" data-start=\"4669\"\u003e\n\u003ch2 data-end=\"4717\" data-start=\"4674\"\u003e4. Pre-clinical \u0026amp; Translational Evidence\u003c\/h2\u003e\n\u003cul data-end=\"5106\" data-start=\"4719\"\u003e\n\u003cli data-end=\"4855\" data-start=\"4719\"\u003e\n\u003cp data-end=\"4855\" data-start=\"4721\"\u003e\u003cstrong data-end=\"4738\" data-start=\"4721\"\u003eCognition\/AD:\u003c\/strong\u003e Reversal of scopolamine, Aβ, and lesion-induced deficits at \u003cstrong data-end=\"4817\" data-start=\"4799\"\u003every low doses\u003c\/strong\u003e; potentiates LTP and spine markers.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"4964\" data-start=\"4856\"\u003e\n\u003cp data-end=\"4964\" data-start=\"4858\"\u003e\u003cstrong data-end=\"4869\" data-start=\"4858\"\u003eTBI\/PD:\u003c\/strong\u003e Functional recovery and synaptic rebuilding demonstrated in multiple injury\/toxin paradigms.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"5106\" data-start=\"4965\"\u003e\n\u003cp data-end=\"5106\" data-start=\"4967\"\u003e\u003cstrong data-end=\"4994\" data-start=\"4967\"\u003eMechanistic dependency:\u003c\/strong\u003e Genetic or pharmacologic \u003cstrong data-end=\"5038\" data-start=\"5020\"\u003ec-Met blockade\u003c\/strong\u003e blunts Dihexa’s synaptogenic effects, supporting target engagement.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cblockquote data-end=\"5297\" data-start=\"5108\"\u003e\n\u003cp data-end=\"5297\" data-start=\"5110\"\u003e\u003cstrong data-end=\"5136\" data-start=\"5110\"\u003eEvidence quality note:\u003c\/strong\u003e \u003cstrong data-end=\"5163\" data-start=\"5137\"\u003eRobust rodent\/in vitro\u003c\/strong\u003e data with convergent mechanisms. \u003cstrong data-end=\"5231\" data-start=\"5197\"\u003eNo peer-reviewed human studies\u003c\/strong\u003e to date; dose, safety, and efficacy in people remain \u003cstrong data-end=\"5296\" data-start=\"5285\"\u003eunknown\u003c\/strong\u003e.\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003chr data-end=\"5302\" data-start=\"5299\"\u003e\n\u003ch2 data-end=\"5350\" data-start=\"5304\"\u003e5. Emerging Clinical Interests (conceptual)\u003c\/h2\u003e\n\u003cdiv class=\"_tableContainer_1rjym_1\"\u003e\n\u003cdiv class=\"group _tableWrapper_1rjym_13 flex w-fit flex-col-reverse\" tabindex=\"-1\"\u003e\n\u003ctable class=\"w-fit min-w-(--thread-content-width)\" data-end=\"5934\" data-start=\"5352\"\u003e\n\u003cthead data-end=\"5382\" data-start=\"5352\"\u003e\n\u003ctr data-end=\"5382\" data-start=\"5352\"\u003e\n\u003cth data-col-size=\"sm\" data-end=\"5360\" data-start=\"5352\"\u003eField\u003c\/th\u003e\n\u003cth data-col-size=\"md\" data-end=\"5372\" data-start=\"5360\"\u003eRationale\u003c\/th\u003e\n\u003cth data-col-size=\"sm\" data-end=\"5382\" data-start=\"5372\"\u003eStatus\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody data-end=\"5934\" data-start=\"5397\"\u003e\n\u003ctr data-end=\"5486\" data-start=\"5397\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"5421\" data-start=\"5397\"\u003e\u003cstrong data-end=\"5420\" data-start=\"5399\"\u003eAlzheimer’s \/ MCI\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"md\" data-end=\"5471\" data-start=\"5421\"\u003eSynaptic rescue independent of amyloid lowering\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"5486\" data-start=\"5471\"\u003ePreclinical\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"5573\" data-start=\"5487\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"5518\" data-start=\"5487\"\u003e\u003cstrong data-end=\"5517\" data-start=\"5489\"\u003ePost-TBI cognitive rehab\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"md\" data-end=\"5558\" data-start=\"5518\"\u003eStructural plasticity + rehab synergy\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"5573\" data-start=\"5558\"\u003ePreclinical\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"5670\" data-start=\"5574\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"5613\" data-start=\"5574\"\u003e\u003cstrong data-end=\"5612\" data-start=\"5576\"\u003eParkinson’s cognitive\/motivation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"md\" data-end=\"5655\" data-start=\"5613\"\u003eNetwork compensation via synaptogenesis\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"5670\" data-start=\"5655\"\u003ePreclinical\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"5765\" data-start=\"5671\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"5708\" data-start=\"5671\"\u003e\u003cstrong data-end=\"5707\" data-start=\"5673\"\u003eTreatment-resistant depression\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"md\" data-end=\"5750\" data-start=\"5708\"\u003eRapid synaptogenic antidepressant angle\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"5765\" data-start=\"5750\"\u003ePreclinical\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"5845\" data-start=\"5766\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"5804\" data-start=\"5766\"\u003e\u003cstrong data-end=\"5803\" data-start=\"5768\"\u003eAuditory neuropathy\/ototoxicity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"md\" data-end=\"5830\" data-start=\"5804\"\u003eCochlear synapse repair\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"5845\" data-start=\"5830\"\u003ePreclinical\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"5934\" data-start=\"5846\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"5878\" data-start=\"5846\"\u003e\u003cstrong data-end=\"5877\" data-start=\"5848\"\u003eSCI\/peripheral neuropathy\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"md\" data-end=\"5919\" data-start=\"5878\"\u003eNeurite growth \u0026amp; remyelination support\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"5934\" data-start=\"5919\"\u003ePreclinical\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr data-end=\"5939\" data-start=\"5936\"\u003e\n\u003ch2 data-end=\"5970\" data-start=\"5941\"\u003e6. Safety and Tolerability\u003c\/h2\u003e\n\u003cul data-end=\"6974\" data-start=\"5972\"\u003e\n\u003cli data-end=\"6275\" data-start=\"5972\"\u003e\n\u003cp data-end=\"6275\" data-start=\"5974\"\u003e\u003cstrong data-end=\"6009\" data-start=\"5974\"\u003eOn-target oncogenicity concern:\u003c\/strong\u003e \u003cstrong data-end=\"6023\" data-start=\"6010\"\u003eHGF–c-Met\u003c\/strong\u003e is a \u003cstrong data-end=\"6055\" data-start=\"6029\"\u003eproto-oncogene pathway\u003c\/strong\u003e. Chronic potentiation may \u003cstrong data-end=\"6133\" data-start=\"6082\"\u003epromote tumor growth, invasion, or angiogenesis\u003c\/strong\u003e, especially in individuals with \u003cstrong data-end=\"6190\" data-start=\"6166\"\u003ec-Met-driven cancers\u003c\/strong\u003e or premalignant lesions. Long-term carcinogenicity data for Dihexa are \u003cstrong data-end=\"6272\" data-start=\"6262\"\u003eabsent\u003c\/strong\u003e.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"6436\" data-start=\"6276\"\u003e\n\u003cp data-end=\"6436\" data-start=\"6278\"\u003e\u003cstrong data-end=\"6304\" data-start=\"6278\"\u003eCNS AEs (theoretical):\u003c\/strong\u003e Headache, insomnia\/activation, irritability, or abnormal dreams from heightened plasticity signaling; not systematically studied.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"6556\" data-start=\"6437\"\u003e\n\u003cp data-end=\"6556\" data-start=\"6439\"\u003e\u003cstrong data-end=\"6469\" data-start=\"6439\"\u003eCardio-metabolic\/vascular:\u003c\/strong\u003e HGF can be \u003cstrong data-end=\"6499\" data-start=\"6481\"\u003epro-angiogenic\u003c\/strong\u003e; monitor for edema or BP changes in any future trials.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"6675\" data-start=\"6557\"\u003e\n\u003cp data-end=\"6675\" data-start=\"6559\"\u003e\u003cstrong data-end=\"6576\" data-start=\"6559\"\u003eReproductive:\u003c\/strong\u003e Unknown effects on fetal development (HGF is morphogenic) → \u003cstrong data-end=\"6659\" data-start=\"6637\"\u003eavoid in pregnancy\u003c\/strong\u003e conceptually.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"6855\" data-start=\"6676\"\u003e\n\u003cp data-end=\"6855\" data-start=\"6678\"\u003e\u003cstrong data-end=\"6700\" data-start=\"6678\"\u003eDrug interactions:\u003c\/strong\u003e Potential synergy\/interference with \u003cstrong data-end=\"6756\" data-start=\"6737\"\u003emTOR modulators\u003c\/strong\u003e, \u003cstrong data-end=\"6777\" data-start=\"6758\"\u003eantidepressants\u003c\/strong\u003e, \u003cstrong data-end=\"6793\" data-start=\"6779\"\u003estimulants\u003c\/strong\u003e, or \u003cstrong data-end=\"6827\" data-start=\"6798\"\u003eanti-c-Met oncology drugs\u003c\/strong\u003e (crizotinib, capmatinib).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"6974\" data-start=\"6856\"\u003e\n\u003cp data-end=\"6974\" data-start=\"6858\"\u003e\u003cstrong data-end=\"6880\" data-start=\"6858\"\u003eAbuse\/misuse risk:\u003c\/strong\u003e Grey-market “nootropic” products are \u003cstrong data-end=\"6933\" data-start=\"6918\"\u003eunregulated\u003c\/strong\u003e; composition frequently \u003cstrong data-end=\"6973\" data-start=\"6958\"\u003emislabelled\u003c\/strong\u003e.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-end=\"7005\" data-start=\"6976\"\u003e\u003cstrong data-end=\"7005\" data-start=\"6976\"\u003eComparative safety matrix\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"_tableContainer_1rjym_1\"\u003e\n\u003cdiv class=\"group _tableWrapper_1rjym_13 flex w-fit flex-col-reverse\" tabindex=\"-1\"\u003e\n\u003ctable class=\"w-fit min-w-(--thread-content-width)\" data-end=\"7401\" data-start=\"7007\"\u003e\n\u003cthead data-end=\"7073\" data-start=\"7007\"\u003e\n\u003ctr data-end=\"7073\" data-start=\"7007\"\u003e\n\u003cth data-col-size=\"sm\" data-end=\"7017\" data-start=\"7007\"\u003eConcern\u003c\/th\u003e\n\u003cth data-col-size=\"sm\" data-end=\"7030\" data-start=\"7017\"\u003e\u003cstrong data-end=\"7029\" data-start=\"7019\"\u003eDihexa\u003c\/strong\u003e\u003c\/th\u003e\n\u003cth data-col-size=\"sm\" data-end=\"7056\" data-start=\"7030\"\u003e\u003cstrong data-end=\"7055\" data-start=\"7032\"\u003eKetamine\/esketamine\u003c\/strong\u003e\u003c\/th\u003e\n\u003cth data-col-size=\"sm\" data-end=\"7073\" data-start=\"7056\"\u003e\u003cstrong data-end=\"7071\" data-start=\"7058\"\u003eDonepezil\u003c\/strong\u003e\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody data-end=\"7401\" data-start=\"7092\"\u003e\n\u003ctr data-end=\"7201\" data-start=\"7092\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"7104\" data-start=\"7092\"\u003eMechanism\u003c\/td\u003e\n\u003ctd data-end=\"7133\" data-start=\"7104\" data-col-size=\"sm\"\u003e\u003cstrong data-end=\"7132\" data-start=\"7106\"\u003eHGF–c-Met synaptogenic\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-end=\"7168\" data-start=\"7133\" data-col-size=\"sm\"\u003eNMDA modulation → synaptogenesis\u003c\/td\u003e\n\u003ctd data-end=\"7201\" data-start=\"7168\" data-col-size=\"sm\"\u003eAChE inhibition (symptomatic)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"7273\" data-start=\"7202\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"7219\" data-start=\"7202\"\u003eHuman evidence\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"7230\" data-start=\"7219\"\u003e\u003cstrong data-end=\"7229\" data-start=\"7221\"\u003eNone\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-end=\"7247\" data-start=\"7230\" data-col-size=\"sm\"\u003eStrong for TRD\u003c\/td\u003e\n\u003ctd data-end=\"7273\" data-start=\"7247\" data-col-size=\"sm\"\u003eStrong for AD symptoms\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"7340\" data-start=\"7274\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"7291\" data-start=\"7274\"\u003eOncogenic risk\u003c\/td\u003e\n\u003ctd data-end=\"7319\" data-start=\"7291\" data-col-size=\"sm\"\u003e\u003cstrong data-end=\"7318\" data-start=\"7293\"\u003eTheoretical ↑ (c-Met)\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-end=\"7329\" data-start=\"7319\" data-col-size=\"sm\"\u003eNeutral\u003c\/td\u003e\n\u003ctd data-end=\"7340\" data-start=\"7329\" data-col-size=\"sm\"\u003eNeutral\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"7401\" data-start=\"7341\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"7365\" data-start=\"7341\"\u003eAcute psychotomimesis\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"7385\" data-start=\"7365\"\u003eLow (theoretical)\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"7395\" data-start=\"7385\"\u003e\u003cstrong data-end=\"7394\" data-start=\"7387\"\u003eYes\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-end=\"7401\" data-start=\"7395\" data-col-size=\"sm\"\u003eNo\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr data-end=\"7406\" data-start=\"7403\"\u003e\n\u003ch2 data-end=\"7434\" data-start=\"7408\"\u003e7. Regulatory Landscape\u003c\/h2\u003e\n\u003cul data-end=\"7683\" data-start=\"7436\"\u003e\n\u003cli data-end=\"7492\" data-start=\"7436\"\u003e\n\u003cp data-end=\"7492\" data-start=\"7438\"\u003e\u003cstrong data-end=\"7454\" data-start=\"7438\"\u003eNot approved\u003c\/strong\u003e by FDA\/EMA\/PMDA for any indication.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"7580\" data-start=\"7493\"\u003e\n\u003cp data-end=\"7580\" data-start=\"7495\"\u003eExists in \u003cstrong data-end=\"7542\" data-start=\"7505\"\u003epatents and academic publications\u003c\/strong\u003e; no registered therapeutic product.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"7683\" data-start=\"7581\"\u003e\n\u003cp data-end=\"7683\" data-start=\"7583\"\u003e\u003cstrong data-end=\"7600\" data-start=\"7583\"\u003eCompounded\/RC\u003c\/strong\u003e versions online are \u003cstrong data-end=\"7644\" data-start=\"7621\"\u003enot quality-assured\u003c\/strong\u003e and carry \u003cstrong data-end=\"7682\" data-start=\"7655\"\u003eunknown identity\/purity\u003c\/strong\u003e.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-end=\"7688\" data-start=\"7685\"\u003e\n\u003ch2 data-end=\"7730\" data-start=\"7690\"\u003e8. Practical Take \u0026amp; Future Directions\u003c\/h2\u003e\n\u003cul data-end=\"8638\" data-start=\"7732\"\u003e\n\u003cli data-end=\"7906\" data-start=\"7732\"\u003e\n\u003cp data-end=\"7906\" data-start=\"7734\"\u003e\u003cstrong data-end=\"7761\" data-start=\"7734\"\u003eDo not self-experiment.\u003c\/strong\u003e Until \u003cstrong data-end=\"7786\" data-start=\"7768\"\u003eGLP toxicology\u003c\/strong\u003e, \u003cstrong data-end=\"7807\" data-start=\"7788\"\u003ecarcinogenicity\u003c\/strong\u003e, \u003cstrong data-end=\"7823\" data-start=\"7809\"\u003efull PK\/PD\u003c\/strong\u003e, and \u003cstrong data-end=\"7847\" data-start=\"7829\"\u003ephase-1 safety\u003c\/strong\u003e are completed, Dihexa should remain \u003cstrong data-end=\"7903\" data-start=\"7884\"\u003elaboratory-only\u003c\/strong\u003e.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"8484\" data-start=\"7907\"\u003e\n\u003cp data-end=\"7940\" data-start=\"7909\"\u003e\u003cstrong data-end=\"7938\" data-start=\"7909\"\u003eClinical trial blueprint:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul data-end=\"8484\" data-start=\"7943\"\u003e\n\u003cli data-end=\"8142\" data-start=\"7943\"\u003e\n\u003cp data-end=\"8142\" data-start=\"7945\"\u003e\u003cstrong data-end=\"7957\" data-start=\"7945\"\u003ePhase 1:\u003c\/strong\u003e SAD\/MAD in healthy adults with \u003cstrong data-end=\"8011\" data-start=\"7989\"\u003eoncology screening\u003c\/strong\u003e, cutaneous\/thyroid exams, and \u003cstrong data-end=\"8067\" data-start=\"8042\"\u003ecirculating tumor DNA\u003c\/strong\u003e exploratory safety markers; \u003cstrong data-end=\"8124\" data-start=\"8096\"\u003eqEEG\/cognitive batteries\u003c\/strong\u003e for PD signals.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"8339\" data-start=\"8145\"\u003e\n\u003cp data-end=\"8339\" data-start=\"8147\"\u003e\u003cstrong data-end=\"8187\" data-start=\"8147\"\u003ePhase 2a (MCI\/early AD or post-TBI):\u003c\/strong\u003e Biomarker-anchored (functional connectivity MRI, plasma p-tau\/Aβ, neurofilament light), \u003cstrong data-end=\"8297\" data-start=\"8276\"\u003edigital cognition\u003c\/strong\u003e, and \u003cstrong data-end=\"8326\" data-start=\"8303\"\u003espeech\/eye-tracking\u003c\/strong\u003e endpoints.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"8484\" data-start=\"8342\"\u003e\n\u003cp data-end=\"8484\" data-start=\"8344\"\u003e\u003cstrong data-end=\"8364\" data-start=\"8344\"\u003eRisk mitigation:\u003c\/strong\u003e Exclude \u003cstrong data-end=\"8390\" data-start=\"8373\"\u003eactive cancer\u003c\/strong\u003e, mandate \u003cstrong data-end=\"8426\" data-start=\"8400\"\u003eoncologic surveillance\u003c\/strong\u003e, and cap exposure duration until risk is characterized.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"8638\" data-start=\"8485\"\u003e\n\u003cp data-end=\"8638\" data-start=\"8487\"\u003e\u003cstrong data-end=\"8501\" data-start=\"8487\"\u003eChemistry:\u003c\/strong\u003e Explore \u003cstrong data-end=\"8539\" data-start=\"8510\"\u003ebiased c-Met potentiation\u003c\/strong\u003e, \u003cstrong data-end=\"8569\" data-start=\"8541\"\u003ebrain-selective delivery\u003c\/strong\u003e, or \u003cstrong data-end=\"8605\" data-start=\"8574\"\u003eactivity-dependent prodrugs\u003c\/strong\u003e to minimize peripheral exposure.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-end=\"8643\" data-start=\"8640\"\u003e\n\u003ch3 data-end=\"8668\" data-start=\"8645\"\u003eSelected References\u003c\/h3\u003e\n\u003cul data-end=\"9574\" data-start=\"8670\"\u003e\n\u003cli data-end=\"8848\" data-start=\"8670\"\u003e\n\u003cp data-end=\"8848\" data-start=\"8672\"\u003e\u003cem data-end=\"8764\" data-start=\"8672\"\u003eJournal of Pharmacology and Experimental Therapeutics; Neurobiology of Learning and Memory\u003c\/em\u003e — Dihexa’s memory enhancement in rodent models and dose–response characteristics.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"9014\" data-start=\"8849\"\u003e\n\u003cp data-end=\"9014\" data-start=\"8851\"\u003e\u003cem data-end=\"8925\" data-start=\"8851\"\u003eProceedings of the National Academy of Sciences; Journal of Neuroscience\u003c\/em\u003e — HGF–c-Met–mediated synaptogenesis and downstream signaling (ERK\/Akt, spine density).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"9151\" data-start=\"9015\"\u003e\n\u003cp data-end=\"9151\" data-start=\"9017\"\u003e\u003cem data-end=\"9068\" data-start=\"9017\"\u003eNeurotherapeutics; Alzheimer’s Research \u0026amp; Therapy\u003c\/em\u003e — Synaptic rescue frameworks in AD models; plasticity gene programs (BDNF, Arc).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"9258\" data-start=\"9152\"\u003e\n\u003cp data-end=\"9258\" data-start=\"9154\"\u003e\u003cem data-end=\"9194\" data-start=\"9154\"\u003eBrain Research; Experimental Neurology\u003c\/em\u003e — Traumatic brain injury recovery and neurite outgrowth data.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"9353\" data-start=\"9259\"\u003e\n\u003cp data-end=\"9353\" data-start=\"9261\"\u003e\u003cem data-end=\"9305\" data-start=\"9261\"\u003eMovement Disorders; Molecular Neurobiology\u003c\/em\u003e — Parkinsonian model plasticity and behavior.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"9448\" data-start=\"9354\"\u003e\n\u003cp data-end=\"9448\" data-start=\"9356\"\u003e\u003cem data-end=\"9380\" data-start=\"9356\"\u003eHearing Research; JARO\u003c\/em\u003e — Cochlear synaptopathy protection\/repair under HGF potentiation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"9574\" data-start=\"9449\"\u003e\n\u003cp data-end=\"9574\" data-start=\"9451\"\u003e\u003cem data-end=\"9491\" data-start=\"9451\"\u003eCancer Research; Nature Reviews Cancer\u003c\/em\u003e — Biology and oncogenic potential of \u003cstrong data-end=\"9542\" data-start=\"9529\"\u003eHGF–c-Met\u003c\/strong\u003e signaling (context for safety).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Mijn winkel","offers":[{"title":"Default Title","offer_id":52684845711698,"sku":null,"price":100.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1048\/0956\/2450\/files\/Dihexa_1g.png?v=1770834827","url":"https:\/\/sciencepeptideslab.com\/products\/dihexa-1g","provider":"Science Peptides Lab","version":"1.0","type":"link"}