{"product_id":"gw0742-60x10mg","title":"GW0742 100x10mg","description":"\u003cp data-start=\"428\" data-end=\"914\" class=\"\"\u003e\u003cspan style=\"color: rgb(255, 42, 0);\"\u003e\u003cstrong\u003e                                          \u003cspan style=\"text-decoration: underline;\"\u003eNOT \u003c\/span\u003e\u003c\/strong\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cstrong\u003eFOR HUMAN \u003c\/strong\u003e\u003c\/span\u003e\u003c\/span\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cspan style=\"color: rgb(255, 42, 0); text-decoration: underline;\"\u003e\u003cstrong\u003eCONSUMPTION\u003c\/strong\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp data-start=\"428\" data-end=\"914\" class=\"\"\u003e\u003cstrong data-start=\"428\" data-end=\"438\"\u003eGW0742 \u003cmeta charset=\"UTF-8\"\u003e\u003c\/strong\u003eis a \u003cstrong data-end=\"142\" data-start=\"103\"\u003ehighly selective agonist of PPARβ\/δ\u003c\/strong\u003e (a nuclear receptor abundant in \u003cstrong data-end=\"231\" data-start=\"175\"\u003eskeletal muscle, endothelium, liver, and macrophages\u003c\/strong\u003e). Activation upshifts \u003cstrong data-end=\"284\" data-start=\"254\"\u003efatty-acid oxidation (FAO)\u003c\/strong\u003e and \u003cstrong data-end=\"315\" data-start=\"289\"\u003emitochondrial programs\u003c\/strong\u003e (PGC-1α), improves \u003cstrong data-end=\"358\" data-start=\"335\"\u003einsulin sensitivity\u003c\/strong\u003e, and exerts \u003cstrong data-end=\"410\" data-start=\"371\"\u003eanti-inflammatory\/vasculoprotective\u003c\/strong\u003e effects via transrepression of \u003cstrong data-end=\"456\" data-start=\"442\"\u003eNF-κB\/AP-1\u003c\/strong\u003e. It is \u003cstrong data-end=\"494\" data-start=\"464\"\u003enot approved for human use\u003c\/strong\u003e (preclinical tool compound) and \u003cstrong data-end=\"570\" data-start=\"527\"\u003ePPARδ modulators are prohibited by WADA\u003c\/strong\u003e.\u003c\/p\u003e\n\u003chr data-end=\"576\" data-start=\"573\"\u003e\n\u003ch3 data-end=\"635\" data-start=\"578\"\u003eAdditional Benefits of GW0742 Now Under Investigation\u003c\/h3\u003e\n\u003cdiv class=\"_tableContainer_1rjym_1\"\u003e\n\u003cdiv class=\"group _tableWrapper_1rjym_13 flex w-fit flex-col-reverse\" tabindex=\"-1\"\u003e\n\u003ctable class=\"w-fit min-w-(--thread-content-width)\" data-end=\"2177\" data-start=\"637\"\u003e\n\u003cthead data-end=\"665\" data-start=\"637\"\u003e\n\u003ctr data-end=\"665\" data-start=\"637\"\u003e\n\u003cth data-col-size=\"md\" data-end=\"647\" data-start=\"637\"\u003eBenefit\u003c\/th\u003e\n\u003cth data-col-size=\"lg\" data-end=\"665\" data-start=\"647\"\u003eKey take-aways\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody data-end=\"2177\" data-start=\"676\"\u003e\n\u003ctr data-end=\"891\" data-start=\"676\"\u003e\n\u003ctd data-col-size=\"md\" data-end=\"727\" data-start=\"676\"\u003e\u003cstrong data-end=\"726\" data-start=\"678\"\u003e1 Endurance \u0026amp; muscle metabolic reprogramming\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"lg\" data-end=\"891\" data-start=\"727\"\u003eUp-regulates \u003cstrong data-end=\"763\" data-start=\"742\"\u003eCPT-1, PDK4, UCP3\u003c\/strong\u003e, shifts fibers toward \u003cstrong data-end=\"806\" data-start=\"786\"\u003eoxidative\/type I\u003c\/strong\u003e phenotype; improves time-to-exhaustion in rodents—an “exercise-mimetic” signature.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"1057\" data-start=\"892\"\u003e\n\u003ctd data-col-size=\"md\" data-end=\"920\" data-start=\"892\"\u003e\u003cstrong data-end=\"919\" data-start=\"894\"\u003e2 Insulin sensitivity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-end=\"1057\" data-start=\"920\" data-col-size=\"lg\"\u003eEnhances \u003cstrong data-end=\"960\" data-start=\"931\"\u003eglucose tolerance\/HOMA-IR\u003c\/strong\u003e, increases muscle FAO, and reduces \u003cstrong data-end=\"1023\" data-start=\"996\"\u003elipotoxic intermediates\u003c\/strong\u003e in diet-induced obesity models.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"1240\" data-start=\"1058\"\u003e\n\u003ctd data-col-size=\"md\" data-end=\"1092\" data-start=\"1058\"\u003e\u003cstrong data-end=\"1091\" data-start=\"1060\"\u003e3 Atheroprotection \u0026amp; lipids\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-end=\"1240\" data-start=\"1092\" data-col-size=\"lg\"\u003ePromotes cholesterol efflux (\u003cstrong data-end=\"1138\" data-start=\"1123\"\u003eABCA1\/ABCG1\u003c\/strong\u003e), lowers \u003cstrong data-end=\"1162\" data-start=\"1148\"\u003eTG\/non-HDL\u003c\/strong\u003e, and reduces vascular inflammation; smaller plaques in hyperlipidemic mice.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"1383\" data-start=\"1241\"\u003e\n\u003ctd data-col-size=\"md\" data-end=\"1270\" data-start=\"1241\"\u003e\u003cstrong data-end=\"1269\" data-start=\"1243\"\u003e4 Endothelial function\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"lg\" data-end=\"1383\" data-start=\"1270\"\u003eIncreases \u003cstrong data-end=\"1309\" data-start=\"1282\"\u003eeNOS\/NO bioavailability\u003c\/strong\u003e, lowers \u003cstrong data-end=\"1335\" data-start=\"1318\"\u003eVCAM-1\/ICAM-1\u003c\/strong\u003e, improving microvascular responses in models.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"1549\" data-start=\"1384\"\u003e\n\u003ctd data-col-size=\"md\" data-end=\"1411\" data-start=\"1384\"\u003e\u003cstrong data-end=\"1410\" data-start=\"1386\"\u003e5 NAFLD\/MASH signals\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"lg\" data-end=\"1549\" data-start=\"1411\"\u003eDecreases hepatic steatosis via ↑ β-oxidation and ↓ DNL; lowers \u003cstrong data-end=\"1488\" data-start=\"1477\"\u003eALT\/AST\u003c\/strong\u003e and inflammatory transcripts in preclinical liver disease.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"1700\" data-start=\"1550\"\u003e\n\u003ctd data-col-size=\"md\" data-end=\"1592\" data-start=\"1550\"\u003e\u003cstrong data-end=\"1591\" data-start=\"1552\"\u003e6 Anti-inflammatory in gut\/systemic\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"lg\" data-end=\"1700\" data-start=\"1592\"\u003eRestraints \u003cstrong data-end=\"1624\" data-start=\"1605\"\u003eNF-κB cytokines\u003c\/strong\u003e (TNF-α, IL-6); ameliorates colitis severity with better barrier proteins.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"1856\" data-start=\"1701\"\u003e\n\u003ctd data-col-size=\"md\" data-end=\"1726\" data-start=\"1701\"\u003e\u003cstrong data-end=\"1725\" data-start=\"1703\"\u003e7 Renal protection\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"lg\" data-end=\"1856\" data-start=\"1726\"\u003eMitigates \u003cstrong data-end=\"1762\" data-start=\"1738\"\u003eischemia–reperfusion\u003c\/strong\u003e and diabetic-nephropathy injury via mitochondrial preservation and anti-fibrotic signaling.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"2006\" data-start=\"1857\"\u003e\n\u003ctd data-col-size=\"md\" data-end=\"1897\" data-start=\"1857\"\u003e\u003cstrong data-end=\"1896\" data-start=\"1859\"\u003e8 Pulmonary hypertension\/fibrosis\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"lg\" data-end=\"2006\" data-start=\"1897\"\u003eLowers \u003cstrong data-end=\"1921\" data-start=\"1906\"\u003eRV pressure\u003c\/strong\u003e and vascular remodeling in PAH; attenuates \u003cstrong data-end=\"1981\" data-start=\"1965\"\u003eTGF-β–driven\u003c\/strong\u003efibroblast activation.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"2177\" data-start=\"2007\"\u003e\n\u003ctd data-col-size=\"md\" data-end=\"2045\" data-start=\"2007\"\u003e\u003cstrong data-end=\"2044\" data-start=\"2009\"\u003e9 Neuroprotection (preclinical)\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"lg\" data-end=\"2177\" data-start=\"2045\"\u003eImproves neuronal mitochondrial function, reduces microglial cytokines, benefits motor\/cognitive readouts in toxin\/aging models.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr data-end=\"2182\" data-start=\"2179\"\u003e\n\u003ch2 data-end=\"2219\" data-start=\"2184\"\u003e2. Molecular Mechanism of Action\u003c\/h2\u003e\n\u003ch3 data-end=\"2256\" data-start=\"2221\"\u003e2.1 Receptor pharmacodynamics\u003c\/h3\u003e\n\u003cul data-end=\"2609\" data-start=\"2257\"\u003e\n\u003cli data-end=\"2372\" data-start=\"2257\"\u003e\n\u003cp data-end=\"2372\" data-start=\"2259\"\u003e\u003cstrong data-end=\"2274\" data-start=\"2259\"\u003ePPARβ\/δ–RXR\u003c\/strong\u003e heterodimer → \u003cstrong data-end=\"2297\" data-start=\"2289\"\u003ePPRE\u003c\/strong\u003e transcription of FAO\/mitochondrial genes (\u003cstrong data-end=\"2368\" data-start=\"2340\"\u003ePGC-1α, CPT-1, ACO, UCP3\u003c\/strong\u003e).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"2477\" data-start=\"2373\"\u003e\n\u003cp data-end=\"2477\" data-start=\"2375\"\u003e\u003cstrong data-end=\"2395\" data-start=\"2375\"\u003eTransrepression:\u003c\/strong\u003e Interferes with \u003cstrong data-end=\"2426\" data-start=\"2412\"\u003eNF-κB\/AP-1\u003c\/strong\u003e → ↓ inflammatory gene expression (COX-2, TNF-α).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"2539\" data-start=\"2478\"\u003e\n\u003cp data-end=\"2539\" data-start=\"2480\"\u003e\u003cstrong data-end=\"2496\" data-start=\"2480\"\u003eMacrophages:\u003c\/strong\u003e ↑ \u003cstrong data-end=\"2514\" data-start=\"2499\"\u003eABCA1\/ABCG1\u003c\/strong\u003e efflux; M2-like shift.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"2609\" data-start=\"2540\"\u003e\n\u003cp data-end=\"2609\" data-start=\"2542\"\u003e\u003cstrong data-end=\"2558\" data-start=\"2542\"\u003eEndothelium:\u003c\/strong\u003e ↑ \u003cstrong data-end=\"2569\" data-start=\"2561\"\u003eeNOS\u003c\/strong\u003e, ↓ adhesion molecules → vasoprotection.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3 data-end=\"2638\" data-start=\"2611\"\u003e2.2 Down-stream biology\u003c\/h3\u003e\n\u003cdiv class=\"_tableContainer_1rjym_1\"\u003e\n\u003cdiv class=\"group _tableWrapper_1rjym_13 flex w-fit flex-col-reverse\" tabindex=\"-1\"\u003e\n\u003ctable class=\"w-fit min-w-(--thread-content-width)\" data-end=\"3063\" data-start=\"2640\"\u003e\n\u003cthead data-end=\"2682\" data-start=\"2640\"\u003e\n\u003ctr data-end=\"2682\" data-start=\"2640\"\u003e\n\u003cth data-col-size=\"sm\" data-end=\"2650\" data-start=\"2640\"\u003ePathway\u003c\/th\u003e\n\u003cth data-col-size=\"sm\" data-end=\"2671\" data-start=\"2650\"\u003eFunctional outcome\u003c\/th\u003e\n\u003cth data-col-size=\"sm\" data-end=\"2682\" data-start=\"2671\"\u003eContext\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody data-end=\"3063\" data-start=\"2697\"\u003e\n\u003ctr data-end=\"2777\" data-start=\"2697\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"2722\" data-start=\"2697\"\u003e\u003cstrong data-end=\"2721\" data-start=\"2699\"\u003eFAO\/PGC-1α program\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"2758\" data-start=\"2722\"\u003e↑ Oxidative metabolism, endurance\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"2777\" data-start=\"2758\"\u003eSkeletal muscle\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"2850\" data-start=\"2778\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"2796\" data-start=\"2778\"\u003e\u003cstrong data-end=\"2795\" data-start=\"2780\"\u003eABCA1\/ABCG1\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"2833\" data-start=\"2796\"\u003e↑ Cholesterol efflux, ↓ foam cells\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"2850\" data-start=\"2833\"\u003eAtherogenesis\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"2919\" data-start=\"2851\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"2878\" data-start=\"2851\"\u003e\u003cstrong data-end=\"2877\" data-start=\"2853\"\u003eNF-κB\/AP-1 restraint\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"2901\" data-start=\"2878\"\u003e↓ Cytokines\/adhesion\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"2919\" data-start=\"2901\"\u003eVascular \u0026amp; gut\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"2984\" data-start=\"2920\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"2942\" data-start=\"2920\"\u003e\u003cstrong data-end=\"2941\" data-start=\"2922\"\u003eeNOS activation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"2971\" data-start=\"2942\"\u003e↑ NO, endothelial function\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"2984\" data-start=\"2971\"\u003eCV system\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"3063\" data-start=\"2985\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"3018\" data-start=\"2985\"\u003e\u003cstrong data-end=\"3017\" data-start=\"2987\"\u003eAnti-fibrotic (TGF-β axis)\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"3042\" data-start=\"3018\"\u003e↓ Collagen deposition\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"3063\" data-start=\"3042\"\u003eKidney\/lung\/heart\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr data-end=\"3068\" data-start=\"3065\"\u003e\n\u003ch2 data-end=\"3106\" data-start=\"3070\"\u003e3. Pharmacokinetics (preclinical)\u003c\/h2\u003e\n\u003cul data-end=\"3295\" data-start=\"3108\"\u003e\n\u003cli data-end=\"3146\" data-start=\"3108\"\u003e\n\u003cp data-end=\"3146\" data-start=\"3110\"\u003e\u003cstrong data-end=\"3120\" data-start=\"3110\"\u003eRoute:\u003c\/strong\u003e Oral in animal studies.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"3233\" data-start=\"3147\"\u003e\n\u003cp data-end=\"3233\" data-start=\"3149\"\u003e\u003cstrong data-end=\"3162\" data-start=\"3149\"\u003eExposure:\u003c\/strong\u003e Hours-scale half-life in rodents; species-dependent bioavailability.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"3295\" data-start=\"3234\"\u003e\n\u003cp data-end=\"3295\" data-start=\"3236\"\u003e\u003cstrong data-end=\"3251\" data-start=\"3236\"\u003eMetabolism:\u003c\/strong\u003e Likely hepatic oxidation; human PK unknown.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-end=\"3300\" data-start=\"3297\"\u003e\n\u003ch2 data-end=\"3324\" data-start=\"3302\"\u003e4. Evidence Summary\u003c\/h2\u003e\n\u003cul data-end=\"3698\" data-start=\"3326\"\u003e\n\u003cli data-end=\"3470\" data-start=\"3326\"\u003e\n\u003cp data-end=\"3470\" data-start=\"3328\"\u003e\u003cstrong data-end=\"3350\" data-start=\"3328\"\u003eMetabolic disease:\u003c\/strong\u003e Consistent \u003cstrong data-end=\"3385\" data-start=\"3362\"\u003einsulin-sensitizing\u003c\/strong\u003e and \u003cstrong data-end=\"3408\" data-start=\"3390\"\u003eanti-steatotic\u003c\/strong\u003e effects with improved muscle FAO\/glucose uptake in rodents.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"3590\" data-start=\"3471\"\u003e\n\u003cp data-end=\"3590\" data-start=\"3473\"\u003e\u003cstrong data-end=\"3492\" data-start=\"3473\"\u003eCardiovascular:\u003c\/strong\u003e Reduced \u003cstrong data-end=\"3527\" data-start=\"3501\"\u003eatherosclerotic plaque\u003c\/strong\u003e, improved endothelial function, anti-remodeling post-injury.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"3698\" data-start=\"3591\"\u003e\n\u003cp data-end=\"3698\" data-start=\"3593\"\u003e\u003cstrong data-end=\"3621\" data-start=\"3593\"\u003eRenal\/pulmonary\/gut\/CNS:\u003c\/strong\u003e Protection across models via mitochondrial and anti-inflammatory mechanisms.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cblockquote data-end=\"3822\" data-start=\"3700\"\u003e\n\u003cp data-end=\"3822\" data-start=\"3702\"\u003e\u003cstrong data-end=\"3728\" data-start=\"3702\"\u003eEvidence quality note:\u003c\/strong\u003e Strong \u003cstrong data-end=\"3760\" data-start=\"3736\"\u003emechanistic + animal\u003c\/strong\u003e data; \u003cstrong data-end=\"3809\" data-start=\"3767\"\u003eno peer-reviewed human efficacy trials\u003c\/strong\u003e with GW0742.\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003chr data-end=\"3827\" data-start=\"3824\"\u003e\n\u003ch2 data-end=\"3875\" data-start=\"3829\"\u003e5. Emerging Clinical Interests (conceptual)\u003c\/h2\u003e\n\u003cdiv class=\"_tableContainer_1rjym_1\"\u003e\n\u003cdiv class=\"group _tableWrapper_1rjym_13 flex w-fit flex-col-reverse\" tabindex=\"-1\"\u003e\n\u003ctable class=\"w-fit min-w-(--thread-content-width)\" data-end=\"4358\" data-start=\"3877\"\u003e\n\u003cthead data-end=\"3907\" data-start=\"3877\"\u003e\n\u003ctr data-end=\"3907\" data-start=\"3877\"\u003e\n\u003cth data-col-size=\"sm\" data-end=\"3885\" data-start=\"3877\"\u003eField\u003c\/th\u003e\n\u003cth data-col-size=\"sm\" data-end=\"3897\" data-start=\"3885\"\u003eRationale\u003c\/th\u003e\n\u003cth data-col-size=\"sm\" data-end=\"3907\" data-start=\"3897\"\u003eStatus\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody data-end=\"4358\" data-start=\"3922\"\u003e\n\u003ctr data-end=\"4009\" data-start=\"3922\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"3955\" data-start=\"3922\"\u003e\u003cstrong data-end=\"3954\" data-start=\"3924\"\u003eObesity\/insulin resistance\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"3994\" data-start=\"3955\"\u003eMuscle FAO \u0026amp; metabolic flexibility ↑\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"4009\" data-start=\"3994\"\u003ePreclinical\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"4087\" data-start=\"4010\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"4043\" data-start=\"4010\"\u003e\u003cstrong data-end=\"4042\" data-start=\"4012\"\u003eAtherosclerosis prevention\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"4072\" data-start=\"4043\"\u003eEfflux + anti-inflammatory\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"4087\" data-start=\"4072\"\u003ePreclinical\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"4157\" data-start=\"4088\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"4105\" data-start=\"4088\"\u003e\u003cstrong data-end=\"4104\" data-start=\"4090\"\u003eNAFLD\/MASH\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"4142\" data-start=\"4105\"\u003eAnti-steatotic + anti-inflammatory\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"4157\" data-start=\"4142\"\u003ePreclinical\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"4227\" data-start=\"4158\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"4177\" data-start=\"4158\"\u003e\u003cstrong data-end=\"4176\" data-start=\"4160\"\u003ePAH\/fibrosis\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"4212\" data-start=\"4177\"\u003eVascular \u0026amp; fibroblast modulation\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"4227\" data-start=\"4212\"\u003ePreclinical\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"4284\" data-start=\"4228\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"4238\" data-start=\"4228\"\u003e\u003cstrong data-end=\"4237\" data-start=\"4230\"\u003eIBD\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"4269\" data-start=\"4238\"\u003eBarrier + cytokine restraint\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"4284\" data-start=\"4269\"\u003ePreclinical\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"4358\" data-start=\"4285\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"4309\" data-start=\"4285\"\u003e\u003cstrong data-end=\"4308\" data-start=\"4287\"\u003eNeurodegeneration\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"4343\" data-start=\"4309\"\u003eMitochondrial\/anti-inflammatory\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"4358\" data-start=\"4343\"\u003ePreclinical\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr data-end=\"4363\" data-start=\"4360\"\u003e\n\u003ch2 data-end=\"4392\" data-start=\"4365\"\u003e6. Safety \u0026amp; Tolerability\u003c\/h2\u003e\n\u003cul data-end=\"4948\" data-start=\"4394\"\u003e\n\u003cli data-end=\"4424\" data-start=\"4394\"\u003e\n\u003cp data-end=\"4424\" data-start=\"4396\"\u003e\u003cstrong data-end=\"4413\" data-start=\"4396\"\u003eHuman safety:\u003c\/strong\u003e Unknown.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"4633\" data-start=\"4425\"\u003e\n\u003cp data-end=\"4633\" data-start=\"4427\"\u003e\u003cstrong data-end=\"4445\" data-start=\"4427\"\u003eClass concern:\u003c\/strong\u003e Another PPARδ agonist (\u003cstrong data-end=\"4481\" data-start=\"4469\"\u003eGW501516\u003c\/strong\u003e) produced \u003cstrong data-end=\"4516\" data-start=\"4492\"\u003erodent tumorigenesis\u003c\/strong\u003e at high exposures\/long durations; though GW0742 differs, \u003cstrong data-end=\"4616\" data-start=\"4574\"\u003elong-term oncogenic risk is unresolved\u003c\/strong\u003e for the class.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"4757\" data-start=\"4634\"\u003e\n\u003cp data-end=\"4757\" data-start=\"4636\"\u003e\u003cstrong data-end=\"4656\" data-start=\"4636\"\u003eMetabolic drift:\u003c\/strong\u003e Likely \u003cstrong data-end=\"4676\" data-start=\"4664\"\u003eHDL↑\/TG↓\u003c\/strong\u003e benefits; off-target hepatic\/lipid effects at supraphysiologic doses possible.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"4841\" data-start=\"4758\"\u003e\n\u003cp data-end=\"4841\" data-start=\"4760\"\u003e\u003cstrong data-end=\"4782\" data-start=\"4760\"\u003eSport\/anti-doping:\u003c\/strong\u003e \u003cstrong data-end=\"4812\" data-start=\"4783\"\u003ePPARδ agonists are banned\u003c\/strong\u003e; detection programs exist.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"4948\" data-start=\"4842\"\u003e\n\u003cp data-end=\"4948\" data-start=\"4844\"\u003e\u003cstrong data-end=\"4866\" data-start=\"4844\"\u003eDrug interactions:\u003c\/strong\u003e Potential nuclear-receptor\/CYP\/transporter cross-talk—uncharacterized clinically.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-end=\"4972\" data-start=\"4950\"\u003e\u003cstrong data-end=\"4972\" data-start=\"4950\"\u003eComparative matrix\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"_tableContainer_1rjym_1\"\u003e\n\u003cdiv class=\"group _tableWrapper_1rjym_13 flex w-fit flex-col-reverse\" tabindex=\"-1\"\u003e\n\u003ctable class=\"w-fit min-w-(--thread-content-width)\" data-end=\"5322\" data-start=\"4974\"\u003e\n\u003cthead data-end=\"5055\" data-start=\"4974\"\u003e\n\u003ctr data-end=\"5055\" data-start=\"4974\"\u003e\n\u003cth data-col-size=\"sm\" data-end=\"4984\" data-start=\"4974\"\u003eFeature\u003c\/th\u003e\n\u003cth data-col-size=\"sm\" data-end=\"5005\" data-start=\"4984\"\u003e\u003cstrong data-end=\"5004\" data-start=\"4986\"\u003eGW0742 (PPARδ)\u003c\/strong\u003e\u003c\/th\u003e\n\u003cth data-col-size=\"sm\" data-end=\"5028\" data-start=\"5005\"\u003e\u003cstrong data-end=\"5027\" data-start=\"5007\"\u003eGW501516 (PPARδ)\u003c\/strong\u003e\u003c\/th\u003e\n\u003cth data-col-size=\"sm\" data-end=\"5055\" data-start=\"5028\"\u003e\u003cstrong data-end=\"5053\" data-start=\"5030\"\u003eFenofibrate (PPARα)\u003c\/strong\u003e\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody data-end=\"5322\" data-start=\"5074\"\u003e\n\u003ctr data-end=\"5116\" data-start=\"5074\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"5091\" data-start=\"5074\"\u003eHuman approval\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"5100\" data-start=\"5091\"\u003e\u003cstrong data-end=\"5099\" data-start=\"5093\"\u003eNo\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"5105\" data-start=\"5100\"\u003eNo\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"5116\" data-start=\"5105\"\u003e\u003cstrong data-end=\"5114\" data-start=\"5107\"\u003eYes\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"5166\" data-start=\"5117\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"5131\" data-start=\"5117\"\u003eSelectivity\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"5148\" data-start=\"5131\"\u003e\u003cstrong data-end=\"5147\" data-start=\"5133\"\u003eHigh for δ\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"5161\" data-start=\"5148\"\u003eHigh for δ\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"5166\" data-start=\"5161\"\u003eα\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"5257\" data-start=\"5167\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"5183\" data-start=\"5167\"\u003eEndurance\/FAO\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"5210\" data-start=\"5183\"\u003e\u003cstrong data-end=\"5209\" data-start=\"5185\"\u003eStrong (preclinical)\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"5233\" data-start=\"5210\"\u003eStrong (preclinical)\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"5257\" data-start=\"5233\"\u003eMild (liver-centric)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"5322\" data-start=\"5258\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"5282\" data-start=\"5258\"\u003eTumor signal (rodent)\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"5292\" data-start=\"5282\"\u003eUnknown\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"5306\" data-start=\"5292\"\u003e\u003cstrong data-end=\"5305\" data-start=\"5294\"\u003ePresent\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"5322\" data-start=\"5306\"\u003eNone δ-class\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr data-end=\"5327\" data-start=\"5324\"\u003e\n\u003ch2 data-end=\"5355\" data-start=\"5329\"\u003e7. Regulatory Landscape\u003c\/h2\u003e\n\u003cul data-end=\"5484\" data-start=\"5357\"\u003e\n\u003cli data-end=\"5433\" data-start=\"5357\"\u003e\n\u003cp data-end=\"5433\" data-start=\"5359\"\u003e\u003cstrong data-end=\"5370\" data-start=\"5359\"\u003eStatus:\u003c\/strong\u003e \u003cstrong data-end=\"5400\" data-start=\"5371\"\u003ePreclinical research tool\u003c\/strong\u003e; not a medicine or supplement.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"5484\" data-start=\"5434\"\u003e\n\u003cp data-end=\"5484\" data-start=\"5436\"\u003e\u003cstrong data-end=\"5445\" data-start=\"5436\"\u003eWADA:\u003c\/strong\u003e \u003cstrong data-end=\"5460\" data-start=\"5446\"\u003eProhibited\u003c\/strong\u003e (metabolic modulators).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-end=\"5489\" data-start=\"5486\"\u003e\n\u003ch2 data-end=\"5531\" data-start=\"5491\"\u003e8. Practical Take \u0026amp; Future Directions\u003c\/h2\u003e\n\u003cul data-end=\"5941\" data-start=\"5533\"\u003e\n\u003cli data-end=\"5612\" data-start=\"5533\"\u003e\n\u003cp data-end=\"5612\" data-start=\"5535\"\u003e\u003cstrong data-end=\"5545\" data-start=\"5535\"\u003eToday:\u003c\/strong\u003e Laboratory \u003cstrong data-end=\"5585\" data-start=\"5557\"\u003emechanistic studies only\u003c\/strong\u003e; not for human self-use.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"5797\" data-start=\"5613\"\u003e\n\u003cp data-end=\"5797\" data-start=\"5615\"\u003e\u003cstrong data-end=\"5631\" data-start=\"5615\"\u003eNeeded next:\u003c\/strong\u003e Drug-like δ-agonists with \u003cstrong data-end=\"5676\" data-start=\"5658\"\u003esafety windows\u003c\/strong\u003e, GLP tox\/carcinogenicity, and PoM\/PoC trials using \u003cstrong data-end=\"5764\" data-start=\"5728\"\u003emetabolic and vascular endpoints\u003c\/strong\u003e plus \u003cstrong data-end=\"5786\" data-start=\"5770\"\u003eomics\/biopsy\u003c\/strong\u003e markers.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"5941\" data-start=\"5798\"\u003e\n\u003cp data-end=\"5941\" data-start=\"5800\"\u003e\u003cstrong data-end=\"5818\" data-start=\"5800\"\u003eOpportunities:\u003c\/strong\u003e Tissue-targeted or \u003cstrong data-end=\"5865\" data-start=\"5838\"\u003ebiased PPARδ modulators\u003c\/strong\u003e to capture \u003cstrong data-end=\"5898\" data-start=\"5877\"\u003eFAO\/mitochondrial\u003c\/strong\u003e gains while minimizing proliferative risk.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-end=\"5946\" data-start=\"5943\"\u003e\n\u003ch3 data-end=\"5971\" data-start=\"5948\"\u003eSelected References\u003c\/h3\u003e\n\u003cul data-end=\"6461\" data-start=\"5973\"\u003e\n\u003cli data-end=\"6072\" data-start=\"5973\"\u003e\n\u003cp data-end=\"6072\" data-start=\"5975\"\u003eMuscle oxidative switch \u0026amp; FAO gene programs (PPARδ\/PGC-1α): \u003cem data-end=\"6070\" data-start=\"6035\"\u003eCell Metabolism; Nature Medicine.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"6145\" data-start=\"6073\"\u003e\n\u003cp data-end=\"6145\" data-start=\"6075\"\u003ePPARδ in insulin resistance \u0026amp; NAFLD: \u003cem data-end=\"6143\" data-start=\"6112\"\u003eHepatology; Gastroenterology.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"6224\" data-start=\"6146\"\u003e\n\u003cp data-end=\"6224\" data-start=\"6148\"\u003eVascular\/endothelial protection \u0026amp; atherogenesis: \u003cem data-end=\"6222\" data-start=\"6197\"\u003eCirculation; ATVB; JCI.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"6284\" data-start=\"6225\"\u003e\n\u003cp data-end=\"6284\" data-start=\"6227\"\u003eColitis\/IBD and anti-inflammatory effects: \u003cem data-end=\"6282\" data-start=\"6270\"\u003eGut; PNAS.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"6394\" data-start=\"6285\"\u003e\n\u003cp data-end=\"6394\" data-start=\"6287\"\u003eRenal, pulmonary, and cardiac remodeling models: \u003cem data-end=\"6392\" data-start=\"6336\"\u003eKidney Int; Am J Respir Crit Care Med; Cardiovasc Res.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"6461\" data-start=\"6395\"\u003e\n\u003cp data-end=\"6461\" data-start=\"6397\"\u003eWADA\/anti-doping overview: \u003cem data-end=\"6461\" data-start=\"6424\"\u003eDrug Testing \u0026amp; Analysis; WADA Code.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Mijn winkel","offers":[{"title":"Default Title","offer_id":52684865274194,"sku":null,"price":75.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1048\/0956\/2450\/files\/GW-0742_10mg.png?v=1770834938","url":"https:\/\/sciencepeptideslab.com\/products\/gw0742-60x10mg","provider":"Science Peptides Lab","version":"1.0","type":"link"}