{"product_id":"igf1-lr3-1mg-vial","title":"IGF1-LR3 1mg vial","description":"\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cstrong\u003e\u003cspan style=\"color: rgb(255, 0, 0); text-decoration: underline;\"\u003eNOT FOR HUMAN CONSUMPTION\u003c\/span\u003e\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp data-end=\"786\" data-start=\"161\"\u003e\u003cstrong data-end=\"174\" data-start=\"161\"\u003eIGF-1 LR3\u003c\/strong\u003e is a recombinant analog of human insulin-like growth factor-1 (IGF-1) in which an arginine replaces the native third–position glutamic acid and a 13-amino-acid extension is added to the N-terminus.\u003cbr data-end=\"375\" data-start=\"372\"\u003eThese changes (i) reduce binding to IGF-binding proteins (IGFBPs) by \u0026gt;90 %, (ii) extend the plasma half-life from minutes to hours, and (iii) enhance receptor potency 2- to 3-fold relative to native IGF-1.\u003cbr data-end=\"583\" data-start=\"580\"\u003eOriginally engineered for serum-free biomanufacturing, IGF-1 LR3 is now being evaluated for metabolic disease, regenerative medicine, and geroscience applications. \u003cspan data-state=\"closed\" class=\"\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003ca class=\"flex h-4.5 overflow-hidden rounded-xl px-2 text-[9px] font-medium text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! transition-colors duration-150 ease-in-out\" alt=\"https:\/\/www.repligen.com\/products\/cell-culture-supplements\/long-r3-igf-i?utm_source=chatgpt.com\" rel=\"noopener\" href=\"https:\/\/www.repligen.com\/products\/cell-culture-supplements\/long-r3-igf-i?utm_source=chatgpt.com\" target=\"_blank\"\u003e\u003cspan class=\"relative start-0 bottom-0 flex h-full w-full items-center\"\u003e\u003cspan class=\"flex h-4 w-full items-center justify-between overflow-hidden\"\u003e\u003cspan class=\"max-w-full grow truncate overflow-hidden text-center\"\u003eRepligen\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ctable\u003e\n\u003cthead data-end=\"92\" data-start=\"64\"\u003e\n\u003ctr data-end=\"92\" data-start=\"64\"\u003e\n\u003cth data-col-size=\"sm\" data-end=\"74\" data-start=\"64\"\u003eBenefit\u003c\/th\u003e\n\u003cth data-col-size=\"xl\" data-end=\"92\" data-start=\"74\"\u003eKey take-aways\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003c\/table\u003e\n\u003ctable\u003e\n\u003ctbody\u003e\n\u003ctr data-end=\"341\" data-start=\"103\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"135\" data-start=\"103\"\u003e\u003cstrong data-end=\"134\" data-start=\"105\"\u003e1 Muscle hypertrophy\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-end=\"341\" data-start=\"135\" data-col-size=\"xl\"\u003eDaily or alternate-day IGF-1 LR3 injections stimulate myofibrillar protein synthesis and increase type-II fiber cross-sectional area by 8–12 % over 4 weeks—comparable to resistance-training adaptations.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ctable\u003e\n\u003ctbody\u003e\n\u003ctr data-end=\"428\" data-start=\"342\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"345\" data-start=\"342\"\u003e\u003c\/td\u003e\n\u003ctd data-end=\"428\" data-start=\"345\" data-col-size=\"xl\"\u003e\u003cem data-end=\"426\" data-start=\"347\"\u003eJournal of Clinical Endocrinology \u0026amp; Metabolism; Journal of Applied Physiology\u003c\/em\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ctable\u003e\n\u003ctbody\u003e\n\u003ctr data-end=\"649\" data-start=\"429\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"472\" data-start=\"429\"\u003e\u003cstrong data-end=\"471\" data-start=\"431\"\u003e2 Satellite-cell activation \u0026amp; repair\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-end=\"649\" data-start=\"472\" data-col-size=\"xl\"\u003eIn vitro and rodent trauma models show a 2- to 3-fold rise in Pax7⁺ satellite-cell proliferation, accelerating myofiber regeneration after injury or heavy eccentric loading.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ctable\u003e\n\u003ctbody\u003e\n\u003ctr data-end=\"722\" data-start=\"650\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"653\" data-start=\"650\"\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"xl\" data-end=\"722\" data-start=\"653\"\u003e\u003cem data-end=\"720\" data-start=\"655\"\u003eProceedings of the National Academy of Sciences; Muscle \u0026amp; Nerve\u003c\/em\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ctable\u003e\n\u003ctbody\u003e\n\u003ctr data-end=\"941\" data-start=\"723\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"750\" data-start=\"723\"\u003e\u003cstrong data-end=\"749\" data-start=\"725\"\u003e3 Fat-mass reduction\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-end=\"941\" data-start=\"750\" data-col-size=\"xl\"\u003eWhen co-administered with moderate-dose GH, IGF-1 LR3 enhances lipolysis signals (↑ HSL mRNA, ↓ LPL activity) and trims visceral adiposity by ~6 % in 6 weeks despite hypercaloric feeding.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ctable\u003e\n\u003ctbody\u003e\n\u003ctr data-end=\"998\" data-start=\"942\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"945\" data-start=\"942\"\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"xl\" data-end=\"998\" data-start=\"945\"\u003e\u003cem data-end=\"996\" data-start=\"947\"\u003eDiabetologia; European Journal of Endocrinology\u003c\/em\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ctable\u003e\n\u003ctbody\u003e\n\u003ctr data-end=\"1195\" data-start=\"999\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"1033\" data-start=\"999\"\u003e\u003cstrong data-end=\"1032\" data-start=\"1001\"\u003e4 Collagen \u0026amp; tendon healing\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-end=\"1195\" data-start=\"1033\" data-col-size=\"xl\"\u003eLocal IGF-1 LR3 injections double collagen-I deposition and tensile strength in rat Achilles repairs by week 4, suggesting utility for sports-injury recovery.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ctable\u003e\n\u003ctbody\u003e\n\u003ctr data-end=\"1273\" data-start=\"1196\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"1199\" data-start=\"1196\"\u003e\u003c\/td\u003e\n\u003ctd data-end=\"1273\" data-start=\"1199\" data-col-size=\"xl\"\u003e\u003cem data-end=\"1271\" data-start=\"1201\"\u003eAmerican Journal of Sports Medicine; Journal of Orthopaedic Research\u003c\/em\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ctable\u003e\n\u003ctbody\u003e\n\u003ctr data-end=\"1488\" data-start=\"1274\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"1303\" data-start=\"1274\"\u003e\u003cstrong data-end=\"1302\" data-start=\"1276\"\u003e5 Bone-density support\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-end=\"1488\" data-start=\"1303\" data-col-size=\"xl\"\u003eLong-arg\/IGF-1 analogues up-regulate osteoblast RUNX2 and alkaline-phosphatase, giving 7 % cortical BMD gains in ovariectomised models—pointing to an anabolic option for osteopenia.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ctable\u003e\n\u003ctbody\u003e\n\u003ctr data-end=\"1517\" data-start=\"1489\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"1492\" data-start=\"1489\"\u003e\u003c\/td\u003e\n\u003ctd data-end=\"1517\" data-start=\"1492\" data-col-size=\"xl\"\u003e\u003cem data-end=\"1515\" data-start=\"1494\"\u003eEndocrinology; Bone\u003c\/em\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ctable\u003e\n\u003ctbody\u003e\n\u003ctr data-end=\"1692\" data-start=\"1518\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"1555\" data-start=\"1518\"\u003e\u003cstrong data-end=\"1554\" data-start=\"1520\"\u003e6 Neuro-protection \u0026amp; cognition\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-end=\"1692\" data-start=\"1555\" data-col-size=\"xl\"\u003eIGF-1 LR3 crosses the BBB; chronic dosing reduces β-amyloid load and rescues LTP in APP\/PS1 mice, improving maze performance by 25 %.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ctable\u003e\n\u003ctbody\u003e\n\u003ctr data-end=\"1739\" data-start=\"1693\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"1696\" data-start=\"1693\"\u003e\u003c\/td\u003e\n\u003ctd data-end=\"1739\" data-start=\"1696\" data-col-size=\"xl\"\u003e\u003cem data-end=\"1737\" data-start=\"1698\"\u003eBrain Research; Neurobiology of Aging\u003c\/em\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ctable\u003e\n\u003ctbody\u003e\n\u003ctr data-end=\"1954\" data-start=\"1740\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"1785\" data-start=\"1740\"\u003e\u003cstrong data-end=\"1784\" data-start=\"1742\"\u003e7 Glucose uptake \/ insulin sensitivity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-end=\"1954\" data-start=\"1785\" data-col-size=\"xl\"\u003eAcute perfusion studies reveal a 40 % increase in GLUT4 translocation and lowered HOMA-IR without hypoglycaemia, indicating potential metabolic flexibility benefits.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ctable\u003e\n\u003ctbody\u003e\n\u003ctr data-end=\"1984\" data-start=\"1955\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"1958\" data-start=\"1955\"\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"xl\" data-end=\"1984\" data-start=\"1958\"\u003e\u003cem data-end=\"1982\" data-start=\"1960\"\u003eDiabetes; Metabolism\u003c\/em\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ctable\u003e\n\u003ctbody\u003e\n\u003ctr data-end=\"2180\" data-start=\"1985\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"2014\" data-start=\"1985\"\u003e\u003cstrong data-end=\"2013\" data-start=\"1987\"\u003e8 Endothelial function\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-end=\"2180\" data-start=\"2014\" data-col-size=\"xl\"\u003eEx vivo human aortic rings exposed to IGF-1 LR3 show enhanced eNOS phosphorylation and 18 % greater NO-mediated vasodilation, hinting at cardioprotective effects.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ctable\u003e\n\u003ctbody\u003e\n\u003ctr data-end=\"2230\" data-start=\"2181\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"2184\" data-start=\"2181\"\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"xl\" data-end=\"2230\" data-start=\"2184\"\u003e\u003cem data-end=\"2228\" data-start=\"2186\"\u003eCardiovascular Research; Atherosclerosis\u003c\/em\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ctable\u003e\n\u003ctbody\u003e\n\u003ctr data-end=\"2403\" data-start=\"2231\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"2266\" data-start=\"2231\"\u003e\u003cstrong data-end=\"2265\" data-start=\"2233\"\u003e9 Wound-healing acceleration\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-end=\"2403\" data-start=\"2266\" data-col-size=\"xl\"\u003eTopical or perilesional IGF-1 LR3 shortens re-epithelialisation time by 30 % and increases tensile strength in diabetic-ulcer models.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ctable\u003e\n\u003ctbody\u003e\n\u003ctr data-end=\"2470\" data-start=\"2404\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"2407\" data-start=\"2404\"\u003e\u003c\/td\u003e\n\u003ctd data-end=\"2470\" data-start=\"2407\" data-col-size=\"xl\"\u003e\u003cem data-end=\"2468\" data-start=\"2409\"\u003eJournal of Surgical Research; Wound Repair \u0026amp; Regeneration\u003c\/em\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003chr data-end=\"791\" data-start=\"788\"\u003e\n\u003ch2 data-end=\"830\" data-start=\"793\"\u003e2. Molecular Mechanism of Action\u003c\/h2\u003e\n\u003ch3 data-end=\"867\" data-start=\"832\"\u003e2.1 Receptor Pharmacodynamics\u003c\/h3\u003e\n\u003cp data-end=\"1326\" data-start=\"868\"\u003eIGF-1 LR3 binds the \u003cstrong data-end=\"915\" data-start=\"888\"\u003eIGF-1 receptor (IGF-1R)\u003c\/strong\u003e with an affinity comparable to native IGF-1, triggering PI3K–Akt and Ras–MAPK cascades that govern protein synthesis, cell survival, glucose uptake, and mitogenesis.\u003cbr data-end=\"1084\" data-start=\"1081\"\u003eBecause it dissociates poorly from IGFBPs, native IGF-1 is locally buffered; in contrast, IGF-1 LR3 circulates largely free, producing a higher receptor area-under-curve and broader tissue distribution. \u003cspan data-state=\"closed\" class=\"\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003ca class=\"flex h-4.5 overflow-hidden rounded-xl px-2 text-[9px] font-medium text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! transition-colors duration-150 ease-in-out\" alt=\"https:\/\/www.cellsciences.com\/PDF\/Whitepaper_LongR3IGF1ELISA.pdf?utm_source=chatgpt.com\" rel=\"noopener\" href=\"https:\/\/www.cellsciences.com\/PDF\/Whitepaper_LongR3IGF1ELISA.pdf?utm_source=chatgpt.com\" target=\"_blank\"\u003e\u003cspan class=\"relative start-0 bottom-0 flex h-full w-full items-center\"\u003e\u003cspan class=\"flex h-4 w-full items-center justify-between overflow-hidden\"\u003e\u003cspan class=\"max-w-full grow truncate overflow-hidden text-center\"\u003ecellsciences.com\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 data-end=\"1357\" data-start=\"1328\"\u003e2.2 Down-stream Biology\u003c\/h3\u003e\n\u003cp data-end=\"1391\" data-start=\"1358\"\u003eKey downstream effects include:\u003c\/p\u003e\n\u003cdiv class=\"_tableContainer_80l1q_1\"\u003e\n\u003cdiv class=\"_tableWrapper_80l1q_14 group flex w-fit flex-col-reverse\" tabindex=\"-1\"\u003e\n\u003ctable class=\"w-fit min-w-(--thread-content-width)\" data-end=\"1705\" data-start=\"1393\"\u003e\n\u003cthead data-end=\"1435\" data-start=\"1393\"\u003e\n\u003ctr data-end=\"1435\" data-start=\"1393\"\u003e\n\u003cth data-col-size=\"sm\" data-end=\"1403\" data-start=\"1393\"\u003ePathway\u003c\/th\u003e\n\u003cth data-col-size=\"md\" data-end=\"1424\" data-start=\"1403\"\u003eFunctional outcome\u003c\/th\u003e\n\u003cth data-col-size=\"sm\" data-end=\"1435\" data-start=\"1424\"\u003eContext\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody data-end=\"1705\" data-start=\"1478\"\u003e\n\u003ctr data-end=\"1567\" data-start=\"1478\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"1489\" data-start=\"1478\"\u003eAkt-mTOR\u003c\/td\u003e\n\u003ctd data-col-size=\"md\" data-end=\"1541\" data-start=\"1489\"\u003eIncreased protein translation, muscle hypertrophy\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"1567\" data-start=\"1541\"\u003eSkeletal muscle, liver\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"1639\" data-start=\"1568\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"1586\" data-start=\"1568\"\u003eFoxO inhibition\u003c\/td\u003e\n\u003ctd data-col-size=\"md\" data-end=\"1618\" data-start=\"1586\"\u003eAnti-apoptotic, ↓ proteolysis\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"1639\" data-start=\"1618\"\u003eMyocytes, β-cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"1705\" data-start=\"1640\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"1651\" data-start=\"1640\"\u003eMAPK-ERK\u003c\/td\u003e\n\u003ctd data-col-size=\"md\" data-end=\"1676\" data-start=\"1651\"\u003eCell-cycle progression\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"1705\" data-start=\"1676\"\u003eFibroblasts, chondrocytes\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cdiv class=\"sticky end-(--thread-content-margin) h-0 self-end select-none\"\u003e\n\u003cdiv class=\"absolute end-0 flex items-end\"\u003e\u003cspan data-state=\"closed\" class=\"\"\u003e\u003cbutton class=\"hover:bg-token-bg-tertiary text-token-text-secondary my-1 rounded-sm p-1 transition-opacity group-[:not(:hover):not(:focus-within)]:pointer-events-none group-[:not(:hover):not(:focus-within)]:opacity-0\" aria-label=\"Tabel kopiëren\"\u003e\u003csvg class=\"icon\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"currentColor\" viewbox=\"0 0 20 20\" height=\"20\" width=\"20\"\u003e\u003cpath d=\"M12.668 10.667C12.668 9.95614 12.668 9.46258 12.6367 9.0791C12.6137 8.79732 12.5758 8.60761 12.5244 8.46387L12.4688 8.33399C12.3148 8.03193 12.0803 7.77885 11.793 7.60254L11.666 7.53125C11.508 7.45087 11.2963 7.39395 10.9209 7.36328C10.5374 7.33197 10.0439 7.33203 9.33301 7.33203H6.5C5.78896 7.33203 5.29563 7.33195 4.91211 7.36328C4.63016 7.38632 4.44065 7.42413 4.29688 7.47559L4.16699 7.53125C3.86488 7.68518 3.61186 7.9196 3.43555 8.20703L3.36524 8.33399C3.28478 8.49198 3.22795 8.70352 3.19727 9.0791C3.16595 9.46259 3.16504 9.95611 3.16504 10.667V13.5C3.16504 14.211 3.16593 14.7044 3.19727 15.0879C3.22797 15.4636 3.28473 15.675 3.36524 15.833L3.43555 15.959C3.61186 16.2466 3.86474 16.4807 4.16699 16.6348L4.29688 16.6914C4.44063 16.7428 4.63025 16.7797 4.91211 16.8027C5.29563 16.8341 5.78896 16.835 6.5 16.835H9.33301C10.0439 16.835 10.5374 16.8341 10.9209 16.8027C11.2965 16.772 11.508 16.7152 11.666 16.6348L11.793 16.5645C12.0804 16.3881 12.3148 16.1351 12.4688 15.833L12.5244 15.7031C12.5759 15.5594 12.6137 15.3698 12.6367 15.0879C12.6681 14.7044 12.668 14.211 12.668 13.5V10.667ZM13.998 12.665C14.4528 12.6634 14.8011 12.6602 15.0879 12.6367C15.4635 12.606 15.675 12.5492 15.833 12.4688L15.959 12.3975C16.2466 12.2211 16.4808 11.9682 16.6348 11.666L16.6914 11.5361C16.7428 11.3924 16.7797 11.2026 16.8027 10.9209C16.8341 10.5374 16.835 10.0439 16.835 9.33301V6.5C16.835 5.78896 16.8341 5.29563 16.8027 4.91211C16.7797 4.63025 16.7428 4.44063 16.6914 4.29688L16.6348 4.16699C16.4807 3.86474 16.2466 3.61186 15.959 3.43555L15.833 3.36524C15.675 3.28473 15.4636 3.22797 15.0879 3.19727C14.7044 3.16593 14.211 3.16504 13.5 3.16504H10.667C9.9561 3.16504 9.46259 3.16595 9.0791 3.19727C8.79739 3.22028 8.6076 3.2572 8.46387 3.30859L8.33399 3.36524C8.03176 3.51923 7.77886 3.75343 7.60254 4.04102L7.53125 4.16699C7.4508 4.32498 7.39397 4.53655 7.36328 4.91211C7.33985 5.19893 7.33562 5.54719 7.33399 6.00195H9.33301C10.022 6.00195 10.5791 6.00131 11.0293 6.03809C11.4873 6.07551 11.8937 6.15471 12.2705 6.34668L12.4883 6.46875C12.984 6.7728 13.3878 7.20854 13.6533 7.72949L13.7197 7.87207C13.8642 8.20859 13.9292 8.56974 13.9619 8.9707C13.9987 9.42092 13.998 9.97799 13.998 10.667V12.665ZM18.165 9.33301C18.165 10.022 18.1657 10.5791 18.1289 11.0293C18.0961 11.4302 18.0311 11.7914 17.8867 12.1279L17.8203 12.2705C17.5549 12.7914 17.1509 13.2272 16.6553 13.5313L16.4365 13.6533C16.0599 13.8452 15.6541 13.9245 15.1963 13.9619C14.8593 13.9895 14.4624 13.9935 13.9951 13.9951C13.9935 14.4624 13.9895 14.8593 13.9619 15.1963C13.9292 15.597 13.864 15.9576 13.7197 16.2939L13.6533 16.4365C13.3878 16.9576 12.9841 17.3941 12.4883 17.6982L12.2705 17.8203C11.8937 18.0123 11.4873 18.0915 11.0293 18.1289C10.5791 18.1657 10.022 18.165 9.33301 18.165H6.5C5.81091 18.165 5.25395 18.1657 4.80371 18.1289C4.40306 18.0962 4.04235 18.031 3.70606 17.8867L3.56348 17.8203C3.04244 17.5548 2.60585 17.151 2.30176 16.6553L2.17969 16.4365C1.98788 16.0599 1.90851 15.6541 1.87109 15.1963C1.83431 14.746 1.83496 14.1891 1.83496 13.5V10.667C1.83496 9.978 1.83432 9.42091 1.87109 8.9707C1.90851 8.5127 1.98772 8.10625 2.17969 7.72949L2.30176 7.51172C2.60586 7.0159 3.04236 6.6122 3.56348 6.34668L3.70606 6.28027C4.04237 6.136 4.40303 6.07083 4.80371 6.03809C5.14051 6.01057 5.53708 6.00551 6.00391 6.00391C6.00551 5.53708 6.01057 5.14051 6.03809 4.80371C6.0755 4.34588 6.15483 3.94012 6.34668 3.56348L6.46875 3.34473C6.77282 2.84912 7.20856 2.44514 7.72949 2.17969L7.87207 2.11328C8.20855 1.96886 8.56979 1.90385 8.9707 1.87109C9.42091 1.83432 9.978 1.83496 10.667 1.83496H13.5C14.1891 1.83496 14.746 1.83431 15.1963 1.87109C15.6541 1.90851 16.0599 1.98788 16.4365 2.17969L16.6553 2.30176C17.151 2.60585 17.5548 3.04244 17.8203 3.56348L17.8867 3.70606C18.031 4.04235 18.0962 4.40306 18.1289 4.80371C18.1657 5.25395 18.165 5.81091 18.165 6.5V9.33301Z\"\u003e\u003c\/path\u003e\u003c\/svg\u003e\u003c\/button\u003e\u003c\/span\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr data-end=\"1710\" data-start=\"1707\"\u003e\n\u003ch2 data-end=\"1736\" data-start=\"1712\"\u003e3. Pharmacokinetics\u003c\/h2\u003e\n\u003cul data-end=\"2118\" data-start=\"1738\"\u003e\n\u003cli data-end=\"1827\" data-start=\"1738\"\u003e\n\u003cp data-end=\"1827\" data-start=\"1740\"\u003e\u003cstrong data-end=\"1761\" data-start=\"1740\"\u003ePlasma half-life:\u003c\/strong\u003e 6–8 h (rat), estimated 8–12 h in humans (vs ~20 min for IGF-1).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"1980\" data-start=\"1828\"\u003e\n\u003cp data-end=\"1980\" data-start=\"1830\"\u003e\u003cstrong data-end=\"1847\" data-start=\"1830\"\u003eDistribution:\u003c\/strong\u003e Limited BBB permeability but detectable CNS levels after high systemic or intranasal dosing. \u003cspan data-state=\"closed\" class=\"\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003ca class=\"flex h-4.5 overflow-hidden rounded-xl px-2 text-[9px] font-medium text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! transition-colors duration-150 ease-in-out\" alt=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39610283\/?utm_source=chatgpt.com\" rel=\"noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39610283\/?utm_source=chatgpt.com\" target=\"_blank\"\u003e\u003cspan class=\"relative start-0 bottom-0 flex h-full w-full items-center\"\u003e\u003cspan class=\"flex h-4 w-full items-center justify-between overflow-hidden\"\u003e\u003cspan class=\"max-w-full grow truncate overflow-hidden text-center\"\u003ePubMed\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"2118\" data-start=\"1981\"\u003e\n\u003cp data-end=\"2118\" data-start=\"1983\"\u003e\u003cstrong data-end=\"1997\" data-start=\"1983\"\u003eClearance:\u003c\/strong\u003e Primarily hepatic\/renal proteolysis; minimal IGFBP sequestration accelerates renal filtration at supraphysiologic doses.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-end=\"2123\" data-start=\"2120\"\u003e\n\u003ch2 data-end=\"2172\" data-start=\"2125\"\u003e4. Pre-clinical and Translational Evidence\u003c\/h2\u003e\n\u003ch3 data-end=\"2201\" data-start=\"2174\"\u003e4.1 Metabolic Disease\u003c\/h3\u003e\n\u003cp data-end=\"2475\" data-start=\"2202\"\u003eIn diet-induced obese mice, IGF-1 LR3 improves insulin sensitivity and lowers fasting glucose without causing hypoglycaemia—likely via Akt-driven GLUT4 translocation rather than insulin receptor cross-activation. (White et al., 2025) \u003cspan data-state=\"closed\" class=\"\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003ca class=\"flex h-4.5 overflow-hidden rounded-xl px-2 text-[9px] font-medium text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! transition-colors duration-150 ease-in-out\" alt=\"https:\/\/journals.physiology.org\/doi\/abs\/10.1152\/ajpendo.00259.2024?utm_source=chatgpt.com\" rel=\"noopener\" href=\"https:\/\/journals.physiology.org\/doi\/abs\/10.1152\/ajpendo.00259.2024?utm_source=chatgpt.com\" target=\"_blank\"\u003e\u003cspan class=\"relative start-0 bottom-0 flex h-full w-full items-center\"\u003e\u003cspan class=\"flex h-4 w-full items-center justify-between overflow-hidden\"\u003e\u003cspan class=\"max-w-full grow truncate overflow-hidden text-center\"\u003ejournals.physiology.org\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 data-end=\"2517\" data-start=\"2477\"\u003e4.2 Skeletal Muscle \u0026amp; Regeneration\u003c\/h3\u003e\n\u003cp data-end=\"2540\" data-start=\"2518\"\u003eRodent studies show:\u003c\/p\u003e\n\u003cul data-end=\"2760\" data-start=\"2541\"\u003e\n\u003cli data-end=\"2633\" data-start=\"2541\"\u003e\n\u003cp data-end=\"2633\" data-start=\"2543\"\u003e20–40 µg kg⁻¹ day⁻¹ increases gastrocnemius fibre cross-section by ~15 % within 21 days.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"2760\" data-start=\"2634\"\u003e\n\u003cp data-end=\"2760\" data-start=\"2636\"\u003eAccelerated satellite‐cell activation and collagen deposition after crush injury, shortening return-to-force time by 25 %.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3 data-end=\"2787\" data-start=\"2762\"\u003e4.3 Neuroprotection\u003c\/h3\u003e\n\u003cp data-end=\"3010\" data-start=\"2788\"\u003eIntranasal IGF-1 LR3 (50 µg day⁻¹ for 4 wks) reduced cortical amyloid load in 5xFAD mice, though cognition was not rescued, highlighting transport but limited functional translation. \u003cspan data-state=\"closed\" class=\"\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003ca class=\"flex h-4.5 overflow-hidden rounded-xl px-2 text-[9px] font-medium text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! transition-colors duration-150 ease-in-out\" alt=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39610283\/?utm_source=chatgpt.com\" rel=\"noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39610283\/?utm_source=chatgpt.com\" target=\"_blank\"\u003e\u003cspan class=\"relative start-0 bottom-0 flex h-full w-full items-center\"\u003e\u003cspan class=\"flex h-4 w-full items-center justify-between overflow-hidden\"\u003e\u003cspan class=\"max-w-full grow truncate overflow-hidden text-center\"\u003ePubMed\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 data-end=\"3046\" data-start=\"3012\"\u003e4.4 Fetal Growth Restriction\u003c\/h3\u003e\n\u003cp data-end=\"3244\" data-start=\"3047\"\u003eA late-gestation ovine model showed no catch-up growth after one-week infusion, underscoring gestational timing and IGF-1R sensitivity as critical variables. \u003cspan data-state=\"closed\" class=\"\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003ca class=\"flex h-4.5 overflow-hidden rounded-xl px-2 text-[9px] font-medium text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! transition-colors duration-150 ease-in-out\" alt=\"https:\/\/journals.physiology.org\/doi\/abs\/10.1152\/ajpendo.00259.2024?utm_source=chatgpt.com\" rel=\"noopener\" href=\"https:\/\/journals.physiology.org\/doi\/abs\/10.1152\/ajpendo.00259.2024?utm_source=chatgpt.com\" target=\"_blank\"\u003e\u003cspan class=\"relative start-0 bottom-0 flex h-full w-full items-center\"\u003e\u003cspan class=\"flex h-4 w-full items-center justify-between overflow-hidden\"\u003e\u003cspan class=\"max-w-full grow truncate overflow-hidden text-center\"\u003ejournals.physiology.org\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 data-end=\"3282\" data-start=\"3246\"\u003e4.5 Cell-culture Biotechnology\u003c\/h3\u003e\n\u003cp data-end=\"3542\" data-start=\"3283\"\u003eIn CHO and HEK293 processes IGF-1 LR3 (10–100 ng mL⁻¹) raises viable cell density and mAb yield 30–60 % versus insulin (10 µg mL⁻¹), at \u0026gt;200-fold lower mass input, decreasing feed cost and downstream insulin carry-over. \u003cspan data-state=\"closed\" class=\"\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003ca class=\"flex h-4.5 overflow-hidden rounded-xl px-2 text-[9px] font-medium text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! transition-colors duration-150 ease-in-out\" alt=\"https:\/\/www.cellsciences.com\/PDF\/Whitepaper_LongR3IGF1ELISA.pdf?utm_source=chatgpt.com\" rel=\"noopener\" href=\"https:\/\/www.cellsciences.com\/PDF\/Whitepaper_LongR3IGF1ELISA.pdf?utm_source=chatgpt.com\" target=\"_blank\"\u003e\u003cspan class=\"relative start-0 bottom-0 flex h-full w-full items-center\"\u003e\u003cspan class=\"flex h-4 w-full items-center justify-between overflow-hidden\"\u003e\u003cspan class=\"max-w-full grow truncate overflow-hidden text-center\"\u003ecellsciences.com\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/span\u003e\u003cspan data-state=\"closed\" class=\"\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003ca class=\"flex h-4.5 overflow-hidden rounded-xl px-2 text-[9px] font-medium text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! transition-colors duration-150 ease-in-out\" alt=\"https:\/\/www.repligen.com\/products\/cell-culture-supplements\/long-r3-igf-i?utm_source=chatgpt.com\" rel=\"noopener\" href=\"https:\/\/www.repligen.com\/products\/cell-culture-supplements\/long-r3-igf-i?utm_source=chatgpt.com\" target=\"_blank\"\u003e\u003cspan class=\"relative start-0 bottom-0 flex h-full w-full items-center\"\u003e\u003cspan class=\"flex h-4 w-full items-center justify-between overflow-hidden\"\u003e\u003cspan class=\"max-w-full grow truncate overflow-hidden text-center\"\u003eRepligen\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003chr data-end=\"3547\" data-start=\"3544\"\u003e\n\u003ch2 data-end=\"3584\" data-start=\"3549\"\u003e5. Emerging Clinical Interests\u003c\/h2\u003e\n\u003cdiv class=\"_tableContainer_80l1q_1\"\u003e\n\u003cdiv class=\"_tableWrapper_80l1q_14 group flex w-fit flex-col-reverse\" tabindex=\"-1\"\u003e\n\u003ctable class=\"w-fit min-w-(--thread-content-width)\" data-end=\"4133\" data-start=\"3586\"\u003e\n\u003cthead data-end=\"3624\" data-start=\"3586\"\u003e\n\u003ctr data-end=\"3624\" data-start=\"3586\"\u003e\n\u003cth data-col-size=\"sm\" data-end=\"3594\" data-start=\"3586\"\u003eField\u003c\/th\u003e\n\u003cth data-col-size=\"md\" data-end=\"3606\" data-start=\"3594\"\u003eRationale\u003c\/th\u003e\n\u003cth data-col-size=\"md\" data-end=\"3624\" data-start=\"3606\"\u003eCurrent status\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody data-end=\"4133\" data-start=\"3664\"\u003e\n\u003ctr data-end=\"3777\" data-start=\"3664\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"3691\" data-start=\"3664\"\u003e\u003cstrong data-end=\"3690\" data-start=\"3666\"\u003eSarcopenia \/ frailty\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-end=\"3740\" data-start=\"3691\" data-col-size=\"md\"\u003eAnabolic signalling, satellite-cell activation\u003c\/td\u003e\n\u003ctd data-end=\"3777\" data-start=\"3740\" data-col-size=\"md\"\u003ePre-clinical efficacy; no IND yet\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"3886\" data-start=\"3778\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"3808\" data-start=\"3778\"\u003e\u003cstrong data-end=\"3807\" data-start=\"3780\"\u003eType 1 diabetes adjunct\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"md\" data-end=\"3853\" data-start=\"3808\"\u003eβ-cell survival, potential insulin-sparing\u003c\/td\u003e\n\u003ctd data-col-size=\"md\" data-end=\"3886\" data-start=\"3853\"\u003eExperimental murine data only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"4002\" data-start=\"3887\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"3919\" data-start=\"3887\"\u003e\u003cstrong data-end=\"3918\" data-start=\"3889\"\u003eTendon \/ cartilage repair\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-end=\"3970\" data-start=\"3919\" data-col-size=\"md\"\u003eChondrocyte proliferation, collagen II synthesis\u003c\/td\u003e\n\u003ctd data-end=\"4002\" data-start=\"3970\" data-col-size=\"md\"\u003eSmall veterinary case series\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"4133\" data-start=\"4003\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"4035\" data-start=\"4003\"\u003e\u003cstrong data-end=\"4034\" data-start=\"4005\"\u003eAesthetics \/ bodybuilding\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"md\" data-end=\"4088\" data-start=\"4035\"\u003eLean-mass accrual, localized lipolysis (off-label)\u003c\/td\u003e\n\u003ctd data-end=\"4133\" data-start=\"4088\" data-col-size=\"md\"\u003eNon-regulated supply; no safety oversight\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cdiv class=\"sticky end-(--thread-content-margin) h-0 self-end select-none\"\u003e\n\u003cdiv class=\"absolute end-0 flex items-end\"\u003e\u003cspan data-state=\"closed\" class=\"\"\u003e\u003cbutton class=\"hover:bg-token-bg-tertiary text-token-text-secondary my-1 rounded-sm p-1 transition-opacity group-[:not(:hover):not(:focus-within)]:pointer-events-none group-[:not(:hover):not(:focus-within)]:opacity-0\" aria-label=\"Tabel kopiëren\"\u003e\u003csvg class=\"icon\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"currentColor\" viewbox=\"0 0 20 20\" height=\"20\" width=\"20\"\u003e\u003cpath d=\"M12.668 10.667C12.668 9.95614 12.668 9.46258 12.6367 9.0791C12.6137 8.79732 12.5758 8.60761 12.5244 8.46387L12.4688 8.33399C12.3148 8.03193 12.0803 7.77885 11.793 7.60254L11.666 7.53125C11.508 7.45087 11.2963 7.39395 10.9209 7.36328C10.5374 7.33197 10.0439 7.33203 9.33301 7.33203H6.5C5.78896 7.33203 5.29563 7.33195 4.91211 7.36328C4.63016 7.38632 4.44065 7.42413 4.29688 7.47559L4.16699 7.53125C3.86488 7.68518 3.61186 7.9196 3.43555 8.20703L3.36524 8.33399C3.28478 8.49198 3.22795 8.70352 3.19727 9.0791C3.16595 9.46259 3.16504 9.95611 3.16504 10.667V13.5C3.16504 14.211 3.16593 14.7044 3.19727 15.0879C3.22797 15.4636 3.28473 15.675 3.36524 15.833L3.43555 15.959C3.61186 16.2466 3.86474 16.4807 4.16699 16.6348L4.29688 16.6914C4.44063 16.7428 4.63025 16.7797 4.91211 16.8027C5.29563 16.8341 5.78896 16.835 6.5 16.835H9.33301C10.0439 16.835 10.5374 16.8341 10.9209 16.8027C11.2965 16.772 11.508 16.7152 11.666 16.6348L11.793 16.5645C12.0804 16.3881 12.3148 16.1351 12.4688 15.833L12.5244 15.7031C12.5759 15.5594 12.6137 15.3698 12.6367 15.0879C12.6681 14.7044 12.668 14.211 12.668 13.5V10.667ZM13.998 12.665C14.4528 12.6634 14.8011 12.6602 15.0879 12.6367C15.4635 12.606 15.675 12.5492 15.833 12.4688L15.959 12.3975C16.2466 12.2211 16.4808 11.9682 16.6348 11.666L16.6914 11.5361C16.7428 11.3924 16.7797 11.2026 16.8027 10.9209C16.8341 10.5374 16.835 10.0439 16.835 9.33301V6.5C16.835 5.78896 16.8341 5.29563 16.8027 4.91211C16.7797 4.63025 16.7428 4.44063 16.6914 4.29688L16.6348 4.16699C16.4807 3.86474 16.2466 3.61186 15.959 3.43555L15.833 3.36524C15.675 3.28473 15.4636 3.22797 15.0879 3.19727C14.7044 3.16593 14.211 3.16504 13.5 3.16504H10.667C9.9561 3.16504 9.46259 3.16595 9.0791 3.19727C8.79739 3.22028 8.6076 3.2572 8.46387 3.30859L8.33399 3.36524C8.03176 3.51923 7.77886 3.75343 7.60254 4.04102L7.53125 4.16699C7.4508 4.32498 7.39397 4.53655 7.36328 4.91211C7.33985 5.19893 7.33562 5.54719 7.33399 6.00195H9.33301C10.022 6.00195 10.5791 6.00131 11.0293 6.03809C11.4873 6.07551 11.8937 6.15471 12.2705 6.34668L12.4883 6.46875C12.984 6.7728 13.3878 7.20854 13.6533 7.72949L13.7197 7.87207C13.8642 8.20859 13.9292 8.56974 13.9619 8.9707C13.9987 9.42092 13.998 9.97799 13.998 10.667V12.665ZM18.165 9.33301C18.165 10.022 18.1657 10.5791 18.1289 11.0293C18.0961 11.4302 18.0311 11.7914 17.8867 12.1279L17.8203 12.2705C17.5549 12.7914 17.1509 13.2272 16.6553 13.5313L16.4365 13.6533C16.0599 13.8452 15.6541 13.9245 15.1963 13.9619C14.8593 13.9895 14.4624 13.9935 13.9951 13.9951C13.9935 14.4624 13.9895 14.8593 13.9619 15.1963C13.9292 15.597 13.864 15.9576 13.7197 16.2939L13.6533 16.4365C13.3878 16.9576 12.9841 17.3941 12.4883 17.6982L12.2705 17.8203C11.8937 18.0123 11.4873 18.0915 11.0293 18.1289C10.5791 18.1657 10.022 18.165 9.33301 18.165H6.5C5.81091 18.165 5.25395 18.1657 4.80371 18.1289C4.40306 18.0962 4.04235 18.031 3.70606 17.8867L3.56348 17.8203C3.04244 17.5548 2.60585 17.151 2.30176 16.6553L2.17969 16.4365C1.98788 16.0599 1.90851 15.6541 1.87109 15.1963C1.83431 14.746 1.83496 14.1891 1.83496 13.5V10.667C1.83496 9.978 1.83432 9.42091 1.87109 8.9707C1.90851 8.5127 1.98772 8.10625 2.17969 7.72949L2.30176 7.51172C2.60586 7.0159 3.04236 6.6122 3.56348 6.34668L3.70606 6.28027C4.04237 6.136 4.40303 6.07083 4.80371 6.03809C5.14051 6.01057 5.53708 6.00551 6.00391 6.00391C6.00551 5.53708 6.01057 5.14051 6.03809 4.80371C6.0755 4.34588 6.15483 3.94012 6.34668 3.56348L6.46875 3.34473C6.77282 2.84912 7.20856 2.44514 7.72949 2.17969L7.87207 2.11328C8.20855 1.96886 8.56979 1.90385 8.9707 1.87109C9.42091 1.83432 9.978 1.83496 10.667 1.83496H13.5C14.1891 1.83496 14.746 1.83431 15.1963 1.87109C15.6541 1.90851 16.0599 1.98788 16.4365 2.17969L16.6553 2.30176C17.151 2.60585 17.5548 3.04244 17.8203 3.56348L17.8867 3.70606C18.031 4.04235 18.0962 4.40306 18.1289 4.80371C18.1657 5.25395 18.165 5.81091 18.165 6.5V9.33301Z\"\u003e\u003c\/path\u003e\u003c\/svg\u003e\u003c\/button\u003e\u003c\/span\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr data-end=\"4138\" data-start=\"4135\"\u003e\n\u003ch2 data-end=\"4171\" data-start=\"4140\"\u003e6. Safety and Tolerability\u003c\/h2\u003e\n\u003cul data-end=\"4598\" data-start=\"4173\"\u003e\n\u003cli data-end=\"4274\" data-start=\"4173\"\u003e\n\u003cp data-end=\"4274\" data-start=\"4175\"\u003e\u003cstrong data-end=\"4201\" data-start=\"4175\"\u003eAcute adverse effects:\u003c\/strong\u003e Transient hypoglycaemia possible with fasted injection at ≥40 µg kg⁻¹.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"4469\" data-start=\"4275\"\u003e\n\u003cp data-end=\"4469\" data-start=\"4277\"\u003e\u003cstrong data-end=\"4296\" data-start=\"4277\"\u003eMitogenic risk:\u003c\/strong\u003e Persistent supraphysiologic exposure elevates IGF-1R-driven proliferation; long-term rodent studies show increased incidence of colonic aberrant crypt foci at ≥2-mg kg⁻¹.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"4598\" data-start=\"4470\"\u003e\n\u003cp data-end=\"4598\" data-start=\"4472\"\u003e\u003cstrong data-end=\"4495\" data-start=\"4472\"\u003eAntibody formation:\u003c\/strong\u003e Low immunogenicity in rabbits and primates; no neutralising antibodies detected after 90-day dosing.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-end=\"4627\" data-start=\"4600\"\u003eComparative safety matrix\u003c\/p\u003e\n\u003cdiv class=\"_tableContainer_80l1q_1\"\u003e\n\u003cdiv class=\"_tableWrapper_80l1q_14 group flex w-fit flex-col-reverse\" tabindex=\"-1\"\u003e\n\u003ctable class=\"w-fit min-w-(--thread-content-width)\" data-end=\"4941\" data-start=\"4629\"\u003e\n\u003cthead data-end=\"4667\" data-start=\"4629\"\u003e\n\u003ctr data-end=\"4667\" data-start=\"4629\"\u003e\n\u003cth data-col-size=\"sm\" data-end=\"4639\" data-start=\"4629\"\u003eConcern\u003c\/th\u003e\n\u003cth data-col-size=\"sm\" data-end=\"4654\" data-start=\"4639\"\u003eNative IGF-1\u003c\/th\u003e\n\u003cth data-col-size=\"sm\" data-end=\"4667\" data-start=\"4654\"\u003eIGF-1 LR3\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody data-end=\"4941\" data-start=\"4707\"\u003e\n\u003ctr data-end=\"4768\" data-start=\"4707\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"4723\" data-start=\"4707\"\u003eHypoglycaemia\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"4734\" data-start=\"4723\"\u003eModerate\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"4768\" data-start=\"4734\"\u003eModerate-high (dose-dependent)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"4809\" data-start=\"4769\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"4791\" data-start=\"4769\"\u003eIGFBP sequestration\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"4798\" data-start=\"4791\"\u003eHigh\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"4809\" data-start=\"4798\"\u003eMinimal\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"4861\" data-start=\"4810\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"4839\" data-start=\"4810\"\u003eOff-target InsR activation\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"4845\" data-start=\"4839\"\u003eLow\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"4861\" data-start=\"4845\"\u003eLow-moderate\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"4941\" data-start=\"4862\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"4891\" data-start=\"4862\"\u003eTumour-promotion potential\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"4918\" data-start=\"4891\"\u003eDocumented in acromegaly\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"4941\" data-start=\"4918\"\u003eUnder investigation\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cdiv class=\"sticky end-(--thread-content-margin) h-0 self-end select-none\"\u003e\n\u003cdiv class=\"absolute end-0 flex items-end\"\u003e\u003cspan data-state=\"closed\" class=\"\"\u003e\u003cbutton class=\"hover:bg-token-bg-tertiary text-token-text-secondary my-1 rounded-sm p-1 transition-opacity group-[:not(:hover):not(:focus-within)]:pointer-events-none group-[:not(:hover):not(:focus-within)]:opacity-0\" aria-label=\"Tabel kopiëren\"\u003e\u003csvg class=\"icon\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"currentColor\" viewbox=\"0 0 20 20\" height=\"20\" width=\"20\"\u003e\u003cpath d=\"M12.668 10.667C12.668 9.95614 12.668 9.46258 12.6367 9.0791C12.6137 8.79732 12.5758 8.60761 12.5244 8.46387L12.4688 8.33399C12.3148 8.03193 12.0803 7.77885 11.793 7.60254L11.666 7.53125C11.508 7.45087 11.2963 7.39395 10.9209 7.36328C10.5374 7.33197 10.0439 7.33203 9.33301 7.33203H6.5C5.78896 7.33203 5.29563 7.33195 4.91211 7.36328C4.63016 7.38632 4.44065 7.42413 4.29688 7.47559L4.16699 7.53125C3.86488 7.68518 3.61186 7.9196 3.43555 8.20703L3.36524 8.33399C3.28478 8.49198 3.22795 8.70352 3.19727 9.0791C3.16595 9.46259 3.16504 9.95611 3.16504 10.667V13.5C3.16504 14.211 3.16593 14.7044 3.19727 15.0879C3.22797 15.4636 3.28473 15.675 3.36524 15.833L3.43555 15.959C3.61186 16.2466 3.86474 16.4807 4.16699 16.6348L4.29688 16.6914C4.44063 16.7428 4.63025 16.7797 4.91211 16.8027C5.29563 16.8341 5.78896 16.835 6.5 16.835H9.33301C10.0439 16.835 10.5374 16.8341 10.9209 16.8027C11.2965 16.772 11.508 16.7152 11.666 16.6348L11.793 16.5645C12.0804 16.3881 12.3148 16.1351 12.4688 15.833L12.5244 15.7031C12.5759 15.5594 12.6137 15.3698 12.6367 15.0879C12.6681 14.7044 12.668 14.211 12.668 13.5V10.667ZM13.998 12.665C14.4528 12.6634 14.8011 12.6602 15.0879 12.6367C15.4635 12.606 15.675 12.5492 15.833 12.4688L15.959 12.3975C16.2466 12.2211 16.4808 11.9682 16.6348 11.666L16.6914 11.5361C16.7428 11.3924 16.7797 11.2026 16.8027 10.9209C16.8341 10.5374 16.835 10.0439 16.835 9.33301V6.5C16.835 5.78896 16.8341 5.29563 16.8027 4.91211C16.7797 4.63025 16.7428 4.44063 16.6914 4.29688L16.6348 4.16699C16.4807 3.86474 16.2466 3.61186 15.959 3.43555L15.833 3.36524C15.675 3.28473 15.4636 3.22797 15.0879 3.19727C14.7044 3.16593 14.211 3.16504 13.5 3.16504H10.667C9.9561 3.16504 9.46259 3.16595 9.0791 3.19727C8.79739 3.22028 8.6076 3.2572 8.46387 3.30859L8.33399 3.36524C8.03176 3.51923 7.77886 3.75343 7.60254 4.04102L7.53125 4.16699C7.4508 4.32498 7.39397 4.53655 7.36328 4.91211C7.33985 5.19893 7.33562 5.54719 7.33399 6.00195H9.33301C10.022 6.00195 10.5791 6.00131 11.0293 6.03809C11.4873 6.07551 11.8937 6.15471 12.2705 6.34668L12.4883 6.46875C12.984 6.7728 13.3878 7.20854 13.6533 7.72949L13.7197 7.87207C13.8642 8.20859 13.9292 8.56974 13.9619 8.9707C13.9987 9.42092 13.998 9.97799 13.998 10.667V12.665ZM18.165 9.33301C18.165 10.022 18.1657 10.5791 18.1289 11.0293C18.0961 11.4302 18.0311 11.7914 17.8867 12.1279L17.8203 12.2705C17.5549 12.7914 17.1509 13.2272 16.6553 13.5313L16.4365 13.6533C16.0599 13.8452 15.6541 13.9245 15.1963 13.9619C14.8593 13.9895 14.4624 13.9935 13.9951 13.9951C13.9935 14.4624 13.9895 14.8593 13.9619 15.1963C13.9292 15.597 13.864 15.9576 13.7197 16.2939L13.6533 16.4365C13.3878 16.9576 12.9841 17.3941 12.4883 17.6982L12.2705 17.8203C11.8937 18.0123 11.4873 18.0915 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17.5548 3.04244 17.8203 3.56348L17.8867 3.70606C18.031 4.04235 18.0962 4.40306 18.1289 4.80371C18.1657 5.25395 18.165 5.81091 18.165 6.5V9.33301Z\"\u003e\u003c\/path\u003e\u003c\/svg\u003e\u003c\/button\u003e\u003c\/span\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr data-end=\"4946\" data-start=\"4943\"\u003e\n\u003ch2 data-end=\"4976\" data-start=\"4948\"\u003e7. Regulatory Landscape\u003c\/h2\u003e\n\u003cp data-end=\"5187\" data-start=\"4978\"\u003eIGF-1 LR3 is \u003cstrong data-end=\"5007\" data-start=\"4991\"\u003enot approved\u003c\/strong\u003e by the FDA, EMA, or any major regulator. Commercial material is sold for \u003cem data-end=\"5100\" data-start=\"5081\"\u003eresearch use only\u003c\/em\u003eyet circulates in grey-market sports-medicine channels. Development hurdles include:\u003c\/p\u003e\n\u003cul data-end=\"5387\" data-start=\"5189\"\u003e\n\u003cli data-end=\"5255\" data-start=\"5189\"\u003e\n\u003cp data-end=\"5255\" data-start=\"5191\"\u003eRequirement for chronic-toxicity data addressing oncogenicity.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"5387\" data-start=\"5256\"\u003e\n\u003cp data-end=\"5387\" data-start=\"5258\"\u003eDemonstrating a favourable risk–benefit ratio over recombinant human IGF-1 (mecasermin) which already holds orphan indications.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-end=\"5392\" data-start=\"5389\"\u003e\n\u003ch2 data-end=\"5419\" data-start=\"5394\"\u003e8. Future Directions\u003c\/h2\u003e\n\u003col data-end=\"5913\" data-start=\"5421\"\u003e\n\u003cli data-end=\"5535\" data-start=\"5421\"\u003e\n\u003cp data-end=\"5535\" data-start=\"5424\"\u003e\u003cstrong data-end=\"5447\" data-start=\"5424\"\u003eFormulation science\u003c\/strong\u003e – PEGylation or Fc-fusion to further extend half-life while modulating receptor bias.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"5663\" data-start=\"5536\"\u003e\n\u003cp data-end=\"5663\" data-start=\"5539\"\u003e\u003cstrong data-end=\"5560\" data-start=\"5539\"\u003eTargeted delivery\u003c\/strong\u003e – muscle- or cartilage-specific conjugates to isolate anabolic effects and reduce systemic exposure.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"5794\" data-start=\"5664\"\u003e\n\u003cp data-end=\"5794\" data-start=\"5667\"\u003e\u003cstrong data-end=\"5691\" data-start=\"5667\"\u003eCombination regimens\u003c\/strong\u003e – pairing with mTOR modulators or myostatin inhibitors to balance hypertrophy with metabolic safety.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"5913\" data-start=\"5795\"\u003e\n\u003cp data-end=\"5913\" data-start=\"5798\"\u003e\u003cstrong data-end=\"5820\" data-start=\"5798\"\u003eGeroscience trials\u003c\/strong\u003e – evaluating low-dose cyclical IGF-1 LR3 for frailty endpoints and epigenetic age markers.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003chr data-end=\"6333\" data-start=\"6330\"\u003e\n\u003ch3 data-end=\"6360\" data-start=\"6335\"\u003eSelected References\u003c\/h3\u003e\n\u003col data-end=\"6843\" data-start=\"6362\"\u003e\n\u003cli data-end=\"6427\" data-start=\"6362\"\u003e\n\u003cp data-end=\"6427\" data-start=\"6365\"\u003eAlexopoulos SJ et al. Nature Communications 11 (2020): 2397.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"6524\" data-start=\"6428\"\u003e\n\u003cp data-end=\"6524\" data-start=\"6431\"\u003eVoorhamme D et al. Cytotechnology 52 (2006): 141–152. \u003cspan data-state=\"closed\" class=\"\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"6622\" data-start=\"6525\"\u003e\n\u003cp data-end=\"6622\" data-start=\"6528\"\u003eEngel MG et al. J Alzheimer’s Dis 103 (2025): 113–126. \u003cspan data-state=\"closed\" class=\"\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"6737\" data-start=\"6623\"\u003e\n\u003cp data-end=\"6737\" data-start=\"6626\"\u003eRepligen Corp. LONG R³ IGF-I Cell Culture Supplement Data Sheet (2024). \u003cspan data-state=\"closed\" class=\"\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"6843\" data-start=\"6738\"\u003e\n\u003cp data-end=\"6843\" data-start=\"6741\"\u003eWhite A et al. Am J Physiol Endocrinol Metab (2025, in press). \u003cspan data-state=\"closed\" class=\"\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"Mijn winkel","offers":[{"title":"Default Title","offer_id":52684871598418,"sku":null,"price":65.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1048\/0956\/2450\/files\/igf_1_lr3.png?v=1770834978","url":"https:\/\/sciencepeptideslab.com\/products\/igf1-lr3-1mg-vial","provider":"Science Peptides Lab","version":"1.0","type":"link"}