{"product_id":"pnc-27-10mg-vial","title":"PNC-27 10mg vial","description":"\u003ch3\u003e\n\u003cspan style=\"color: rgb(255, 42, 0);\"\u003e\u003cstrong\u003e                                 \u003cspan style=\"text-decoration: underline;\"\u003eNOT \u003c\/span\u003e\u003c\/strong\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cstrong\u003eFOR HUMAN \u003c\/strong\u003e\u003c\/span\u003e\u003c\/span\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cspan style=\"color: rgb(255, 42, 0); text-decoration: underline;\"\u003e\u003cstrong\u003eCONSUMPTION\u003c\/strong\u003e\u003c\/span\u003e\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003cp data-end=\"578\" data-start=\"118\"\u003e\u003cstrong\u003ePNC-27 \u003c\/strong\u003eis a \u003cstrong data-end=\"157\" data-start=\"130\"\u003e27-mer chimeric peptide\u003c\/strong\u003e in which the p53 HDM-2–binding motif (residues 12-26) is covalently fused to a penetratin-derived “membrane-residency peptide” (MRP) that drives lipid-bilayer insertion. The construct, together with the close analogue PNC-28, was first disclosed in the international patent \u003cstrong data-end=\"450\" data-start=\"432\"\u003eWO2009070650A1\u003c\/strong\u003e and assigned to the SUNY Downstate inventors (sub-licensing now held by Oncolyze, Inc.).\u003cspan data-state=\"closed\" class=\"\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003chr data-end=\"583\" data-start=\"580\"\u003e\n\u003ch4 data-end=\"654\" data-start=\"585\"\u003e2 Molecular Mechanism — From Target Recognition to “Poptosis”\u003c\/h4\u003e\n\u003cdiv class=\"_tableContainer_80l1q_1\"\u003e\n\u003cdiv class=\"_tableWrapper_80l1q_14 group flex w-fit flex-col-reverse\" tabindex=\"-1\"\u003e\n\u003ctable style=\"width: 101.565217%;\" class=\"w-fit min-w-(--thread-content-width)\" data-end=\"1881\" data-start=\"656\"\u003e\n\u003cthead data-end=\"706\" data-start=\"656\"\u003e\n\u003ctr data-end=\"706\" data-start=\"656\"\u003e\n\u003cth style=\"width: 19.064999%;\" data-col-size=\"sm\" data-end=\"663\" data-start=\"656\"\u003eStep\u003c\/th\u003e\n\u003cth style=\"width: 18.721486%;\" data-col-size=\"lg\" data-end=\"681\" data-start=\"663\"\u003eMolecular event\u003c\/th\u003e\n\u003cth style=\"width: 60.801889%;\" data-col-size=\"lg\" data-end=\"706\" data-start=\"681\"\u003eExperimental evidence\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody data-end=\"1881\" data-start=\"759\"\u003e\n\u003ctr data-end=\"1063\" data-start=\"759\"\u003e\n\u003ctd style=\"width: 19.064999%;\" data-col-size=\"sm\" data-end=\"782\" data-start=\"759\"\u003e\u003cstrong data-end=\"781\" data-start=\"761\"\u003eTarget selection\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 18.721486%;\" data-col-size=\"lg\" data-end=\"897\" data-start=\"782\"\u003eMany malignant cells aberrantly traffic HDM-2 (MDM2) to their outer membrane leaflet; normal cells rarely do so.\u003c\/td\u003e\n\u003ctd style=\"width: 60.801889%;\" data-col-size=\"lg\" data-end=\"1063\" data-start=\"897\"\u003eFlow-cytometry and immuno-EM surveys in \u0026gt;30 cancer lines and primary AML blasts; negligible signal in matched normal tissues.\u003cspan data-state=\"closed\" class=\"\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\u003cspan data-state=\"closed\" class=\"\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"1266\" data-start=\"1064\"\u003e\n\u003ctd style=\"width: 19.064999%;\" data-col-size=\"sm\" data-end=\"1080\" data-start=\"1064\"\u003e\u003cstrong data-end=\"1079\" data-start=\"1066\"\u003eAnchoring\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 18.721486%;\" data-col-size=\"lg\" data-end=\"1172\" data-start=\"1080\"\u003eThe p53 segment of PNC-27 docks into the canonical HDM-2 pocket exactly as wild-type p53.\u003c\/td\u003e\n\u003ctd style=\"width: 60.801889%;\" data-col-size=\"lg\" data-end=\"1266\" data-start=\"1172\"\u003eNMR and docking data plus competitive-binding assays.\u003cspan data-state=\"closed\" class=\"\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"1466\" data-start=\"1267\"\u003e\n\u003ctd style=\"width: 19.064999%;\" data-col-size=\"sm\" data-end=\"1310\" data-start=\"1267\"\u003e\u003cstrong data-end=\"1309\" data-start=\"1269\"\u003eMembrane insertion \u0026amp; oligomerisation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 18.721486%;\" data-col-size=\"lg\" data-end=\"1382\" data-start=\"1310\"\u003eThe MRP penetrates the bilayer; HDM-2\/PNC-27 complexes self-assemble.\u003c\/td\u003e\n\u003ctd style=\"width: 60.801889%;\" data-col-size=\"lg\" data-end=\"1466\" data-start=\"1382\"\u003eImmuno-EM visualises ring-shaped oligomers.\u003cspan data-state=\"closed\" class=\"\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"1652\" data-start=\"1467\"\u003e\n\u003ctd style=\"width: 19.064999%;\" data-col-size=\"sm\" data-end=\"1497\" data-start=\"1467\"\u003e\u003cstrong data-end=\"1496\" data-start=\"1469\"\u003ePore formation (4–6 nm)\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 18.721486%;\" data-col-size=\"lg\" data-end=\"1550\" data-start=\"1497\"\u003eTransmembrane pores produce uncontrolled ion flux.\u003c\/td\u003e\n\u003ctd style=\"width: 60.801889%;\" data-col-size=\"lg\" data-end=\"1652\" data-start=\"1550\"\u003eTEM of treated cancer cells; no pores in treated fibroblasts.\u003cspan data-state=\"closed\" class=\"\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"1881\" data-start=\"1653\"\u003e\n\u003ctd style=\"width: 19.064999%;\" data-col-size=\"sm\" data-end=\"1692\" data-start=\"1653\"\u003e\u003cstrong data-end=\"1691\" data-start=\"1655\"\u003eNecrotic cell death — “poptosis”\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 18.721486%;\" data-col-size=\"lg\" data-end=\"1794\" data-start=\"1692\"\u003eRapid LDH release, mitochondrial collapse, and irreversible necrosis independent of p53 signalling.\u003c\/td\u003e\n\u003ctd style=\"width: 60.801889%;\" data-col-size=\"lg\" data-end=\"1881\" data-start=\"1794\"\u003eTime-course cytotoxicity and biomarker panels.\u003cspan data-state=\"closed\" class=\"\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cdiv class=\"sticky end-(--thread-content-margin) h-0 self-end select-none\"\u003e\n\u003cdiv class=\"absolute end-0 flex items-end\"\u003e\u003cspan data-state=\"closed\" class=\"\"\u003e\u003cbutton class=\"hover:bg-token-bg-tertiary text-token-text-secondary my-1 rounded-sm p-1 transition-opacity group-[:not(:hover):not(:focus-within)]:pointer-events-none group-[:not(:hover):not(:focus-within)]:opacity-0\" aria-label=\"Tabel kopiëren\"\u003e\u003csvg class=\"icon\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"currentColor\" viewbox=\"0 0 20 20\" height=\"20\" width=\"20\"\u003e\u003cpath d=\"M12.668 10.667C12.668 9.95614 12.668 9.46258 12.6367 9.0791C12.6137 8.79732 12.5758 8.60761 12.5244 8.46387L12.4688 8.33399C12.3148 8.03193 12.0803 7.77885 11.793 7.60254L11.666 7.53125C11.508 7.45087 11.2963 7.39395 10.9209 7.36328C10.5374 7.33197 10.0439 7.33203 9.33301 7.33203H6.5C5.78896 7.33203 5.29563 7.33195 4.91211 7.36328C4.63016 7.38632 4.44065 7.42413 4.29688 7.47559L4.16699 7.53125C3.86488 7.68518 3.61186 7.9196 3.43555 8.20703L3.36524 8.33399C3.28478 8.49198 3.22795 8.70352 3.19727 9.0791C3.16595 9.46259 3.16504 9.95611 3.16504 10.667V13.5C3.16504 14.211 3.16593 14.7044 3.19727 15.0879C3.22797 15.4636 3.28473 15.675 3.36524 15.833L3.43555 15.959C3.61186 16.2466 3.86474 16.4807 4.16699 16.6348L4.29688 16.6914C4.44063 16.7428 4.63025 16.7797 4.91211 16.8027C5.29563 16.8341 5.78896 16.835 6.5 16.835H9.33301C10.0439 16.835 10.5374 16.8341 10.9209 16.8027C11.2965 16.772 11.508 16.7152 11.666 16.6348L11.793 16.5645C12.0804 16.3881 12.3148 16.1351 12.4688 15.833L12.5244 15.7031C12.5759 15.5594 12.6137 15.3698 12.6367 15.0879C12.6681 14.7044 12.668 14.211 12.668 13.5V10.667ZM13.998 12.665C14.4528 12.6634 14.8011 12.6602 15.0879 12.6367C15.4635 12.606 15.675 12.5492 15.833 12.4688L15.959 12.3975C16.2466 12.2211 16.4808 11.9682 16.6348 11.666L16.6914 11.5361C16.7428 11.3924 16.7797 11.2026 16.8027 10.9209C16.8341 10.5374 16.835 10.0439 16.835 9.33301V6.5C16.835 5.78896 16.8341 5.29563 16.8027 4.91211C16.7797 4.63025 16.7428 4.44063 16.6914 4.29688L16.6348 4.16699C16.4807 3.86474 16.2466 3.61186 15.959 3.43555L15.833 3.36524C15.675 3.28473 15.4636 3.22797 15.0879 3.19727C14.7044 3.16593 14.211 3.16504 13.5 3.16504H10.667C9.9561 3.16504 9.46259 3.16595 9.0791 3.19727C8.79739 3.22028 8.6076 3.2572 8.46387 3.30859L8.33399 3.36524C8.03176 3.51923 7.77886 3.75343 7.60254 4.04102L7.53125 4.16699C7.4508 4.32498 7.39397 4.53655 7.36328 4.91211C7.33985 5.19893 7.33562 5.54719 7.33399 6.00195H9.33301C10.022 6.00195 10.5791 6.00131 11.0293 6.03809C11.4873 6.07551 11.8937 6.15471 12.2705 6.34668L12.4883 6.46875C12.984 6.7728 13.3878 7.20854 13.6533 7.72949L13.7197 7.87207C13.8642 8.20859 13.9292 8.56974 13.9619 8.9707C13.9987 9.42092 13.998 9.97799 13.998 10.667V12.665ZM18.165 9.33301C18.165 10.022 18.1657 10.5791 18.1289 11.0293C18.0961 11.4302 18.0311 11.7914 17.8867 12.1279L17.8203 12.2705C17.5549 12.7914 17.1509 13.2272 16.6553 13.5313L16.4365 13.6533C16.0599 13.8452 15.6541 13.9245 15.1963 13.9619C14.8593 13.9895 14.4624 13.9935 13.9951 13.9951C13.9935 14.4624 13.9895 14.8593 13.9619 15.1963C13.9292 15.597 13.864 15.9576 13.7197 16.2939L13.6533 16.4365C13.3878 16.9576 12.9841 17.3941 12.4883 17.6982L12.2705 17.8203C11.8937 18.0123 11.4873 18.0915 11.0293 18.1289C10.5791 18.1657 10.022 18.165 9.33301 18.165H6.5C5.81091 18.165 5.25395 18.1657 4.80371 18.1289C4.40306 18.0962 4.04235 18.031 3.70606 17.8867L3.56348 17.8203C3.04244 17.5548 2.60585 17.151 2.30176 16.6553L2.17969 16.4365C1.98788 16.0599 1.90851 15.6541 1.87109 15.1963C1.83431 14.746 1.83496 14.1891 1.83496 13.5V10.667C1.83496 9.978 1.83432 9.42091 1.87109 8.9707C1.90851 8.5127 1.98772 8.10625 2.17969 7.72949L2.30176 7.51172C2.60586 7.0159 3.04236 6.6122 3.56348 6.34668L3.70606 6.28027C4.04237 6.136 4.40303 6.07083 4.80371 6.03809C5.14051 6.01057 5.53708 6.00551 6.00391 6.00391C6.00551 5.53708 6.01057 5.14051 6.03809 4.80371C6.0755 4.34588 6.15483 3.94012 6.34668 3.56348L6.46875 3.34473C6.77282 2.84912 7.20856 2.44514 7.72949 2.17969L7.87207 2.11328C8.20855 1.96886 8.56979 1.90385 8.9707 1.87109C9.42091 1.83432 9.978 1.83496 10.667 1.83496H13.5C14.1891 1.83496 14.746 1.83431 15.1963 1.87109C15.6541 1.90851 16.0599 1.98788 16.4365 2.17969L16.6553 2.30176C17.151 2.60585 17.5548 3.04244 17.8203 3.56348L17.8867 3.70606C18.031 4.04235 18.0962 4.40306 18.1289 4.80371C18.1657 5.25395 18.165 5.81091 18.165 6.5V9.33301Z\"\u003e\u003c\/path\u003e\u003c\/svg\u003e\u003c\/button\u003e\u003c\/span\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp data-end=\"1979\" data-start=\"1883\"\u003eResult: PNC-27 lyses tumour cells in minutes while sparing normal cells that lack surface HDM-2.\u003c\/p\u003e\n\u003chr data-end=\"1984\" data-start=\"1981\"\u003e\n\u003ch4 data-end=\"2025\" data-start=\"1986\"\u003e3 Pre-clinical Efficacy Dossier\u003c\/h4\u003e\n\u003cdiv class=\"_tableContainer_80l1q_1\"\u003e\n\u003cdiv class=\"_tableWrapper_80l1q_14 group flex w-fit flex-col-reverse\" tabindex=\"-1\"\u003e\n\u003ctable class=\"w-fit min-w-(--thread-content-width)\" data-end=\"2995\" data-start=\"2027\"\u003e\n\u003cthead data-end=\"2081\" data-start=\"2027\"\u003e\n\u003ctr data-end=\"2081\" data-start=\"2027\"\u003e\n\u003cth data-col-size=\"md\" data-end=\"2050\" data-start=\"2027\"\u003eExperimental context\u003c\/th\u003e\n\u003cth data-col-size=\"sm\" data-end=\"2070\" data-start=\"2050\"\u003eDose \/ conditions\u003c\/th\u003e\n\u003cth data-col-size=\"md\" data-end=\"2081\" data-start=\"2070\"\u003eOutcome\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody data-end=\"2995\" data-start=\"2137\"\u003e\n\u003ctr data-end=\"2352\" data-start=\"2137\"\u003e\n\u003ctd data-col-size=\"md\" data-end=\"2221\" data-start=\"2137\"\u003e\n\u003cstrong data-end=\"2166\" data-start=\"2139\"\u003eSolid-tumour cell lines\u003c\/strong\u003e (breast, pancreatic, melanoma, lung, SK-OV-3 ovarian)\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"2245\" data-start=\"2221\"\u003e1–5 µM (2-h exposure)\u003c\/td\u003e\n\u003ctd data-col-size=\"md\" data-end=\"2352\" data-start=\"2245\"\u003e100 % kill within ≤3 h; paired fibroblasts\/endothelium unaffected.\u003cspan data-state=\"closed\" class=\"\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"2474\" data-start=\"2353\"\u003e\n\u003ctd data-col-size=\"md\" data-end=\"2385\" data-start=\"2353\"\u003e\n\u003cstrong data-end=\"2377\" data-start=\"2355\"\u003ep53-null leukaemia\u003c\/strong\u003e (K562)\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"2396\" data-start=\"2385\"\u003e0.5–2 µM\u003c\/td\u003e\n\u003ctd data-col-size=\"md\" data-end=\"2474\" data-start=\"2396\"\u003eComplete necrosis despite absent p53.\u003cspan data-state=\"closed\" class=\"\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"2626\" data-start=\"2475\"\u003e\n\u003ctd data-col-size=\"md\" data-end=\"2513\" data-start=\"2475\"\u003e\u003cstrong data-end=\"2512\" data-start=\"2477\"\u003ePrimary ovarian-tumour explants\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"2530\" data-start=\"2513\"\u003e1–5 µM ex vivo\u003c\/td\u003e\n\u003ctd data-col-size=\"md\" data-end=\"2626\" data-start=\"2530\"\u003eTumour epithelium lysed; adjacent normal tissue spared.\u003cspan data-state=\"closed\" class=\"\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"2821\" data-start=\"2627\"\u003e\n\u003ctd data-col-size=\"md\" data-end=\"2673\" data-start=\"2627\"\u003e\u003cstrong data-end=\"2672\" data-start=\"2629\"\u003eOvarian xenograft (SK-OV-3, nude mouse)\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"2701\" data-start=\"2673\"\u003e2 mg kg⁻¹ day⁻¹ IP × 28 d\u003c\/td\u003e\n\u003ctd data-col-size=\"md\" data-end=\"2821\" data-start=\"2701\"\u003eSignificant bioluminescence suppression; histology shows reduced viable tumour.\u003cspan data-state=\"closed\" class=\"\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"2995\" data-start=\"2822\"\u003e\n\u003ctd data-col-size=\"md\" data-end=\"2851\" data-start=\"2822\"\u003e\u003cstrong data-end=\"2850\" data-start=\"2824\"\u003ePaclitaxel combination\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"2881\" data-start=\"2851\"\u003ePaclitaxel + PNC-27 (above)\u003c\/td\u003e\n\u003ctd data-col-size=\"md\" data-end=\"2995\" data-start=\"2881\"\u003eBliss-index \u0026lt; 1; PNC-27 eradicates paclitaxel-resistant residual cells.\u003cspan data-state=\"closed\" class=\"\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cdiv class=\"sticky end-(--thread-content-margin) h-0 self-end select-none\"\u003e\n\u003cdiv class=\"absolute end-0 flex items-end\"\u003e\u003cspan data-state=\"closed\" class=\"\"\u003e\u003cbutton class=\"hover:bg-token-bg-tertiary text-token-text-secondary my-1 rounded-sm p-1 transition-opacity group-[:not(:hover):not(:focus-within)]:pointer-events-none group-[:not(:hover):not(:focus-within)]:opacity-0\" aria-label=\"Tabel kopiëren\"\u003e\u003csvg class=\"icon\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"currentColor\" viewbox=\"0 0 20 20\" height=\"20\" width=\"20\"\u003e\u003cpath d=\"M12.668 10.667C12.668 9.95614 12.668 9.46258 12.6367 9.0791C12.6137 8.79732 12.5758 8.60761 12.5244 8.46387L12.4688 8.33399C12.3148 8.03193 12.0803 7.77885 11.793 7.60254L11.666 7.53125C11.508 7.45087 11.2963 7.39395 10.9209 7.36328C10.5374 7.33197 10.0439 7.33203 9.33301 7.33203H6.5C5.78896 7.33203 5.29563 7.33195 4.91211 7.36328C4.63016 7.38632 4.44065 7.42413 4.29688 7.47559L4.16699 7.53125C3.86488 7.68518 3.61186 7.9196 3.43555 8.20703L3.36524 8.33399C3.28478 8.49198 3.22795 8.70352 3.19727 9.0791C3.16595 9.46259 3.16504 9.95611 3.16504 10.667V13.5C3.16504 14.211 3.16593 14.7044 3.19727 15.0879C3.22797 15.4636 3.28473 15.675 3.36524 15.833L3.43555 15.959C3.61186 16.2466 3.86474 16.4807 4.16699 16.6348L4.29688 16.6914C4.44063 16.7428 4.63025 16.7797 4.91211 16.8027C5.29563 16.8341 5.78896 16.835 6.5 16.835H9.33301C10.0439 16.835 10.5374 16.8341 10.9209 16.8027C11.2965 16.772 11.508 16.7152 11.666 16.6348L11.793 16.5645C12.0804 16.3881 12.3148 16.1351 12.4688 15.833L12.5244 15.7031C12.5759 15.5594 12.6137 15.3698 12.6367 15.0879C12.6681 14.7044 12.668 14.211 12.668 13.5V10.667ZM13.998 12.665C14.4528 12.6634 14.8011 12.6602 15.0879 12.6367C15.4635 12.606 15.675 12.5492 15.833 12.4688L15.959 12.3975C16.2466 12.2211 16.4808 11.9682 16.6348 11.666L16.6914 11.5361C16.7428 11.3924 16.7797 11.2026 16.8027 10.9209C16.8341 10.5374 16.835 10.0439 16.835 9.33301V6.5C16.835 5.78896 16.8341 5.29563 16.8027 4.91211C16.7797 4.63025 16.7428 4.44063 16.6914 4.29688L16.6348 4.16699C16.4807 3.86474 16.2466 3.61186 15.959 3.43555L15.833 3.36524C15.675 3.28473 15.4636 3.22797 15.0879 3.19727C14.7044 3.16593 14.211 3.16504 13.5 3.16504H10.667C9.9561 3.16504 9.46259 3.16595 9.0791 3.19727C8.79739 3.22028 8.6076 3.2572 8.46387 3.30859L8.33399 3.36524C8.03176 3.51923 7.77886 3.75343 7.60254 4.04102L7.53125 4.16699C7.4508 4.32498 7.39397 4.53655 7.36328 4.91211C7.33985 5.19893 7.33562 5.54719 7.33399 6.00195H9.33301C10.022 6.00195 10.5791 6.00131 11.0293 6.03809C11.4873 6.07551 11.8937 6.15471 12.2705 6.34668L12.4883 6.46875C12.984 6.7728 13.3878 7.20854 13.6533 7.72949L13.7197 7.87207C13.8642 8.20859 13.9292 8.56974 13.9619 8.9707C13.9987 9.42092 13.998 9.97799 13.998 10.667V12.665ZM18.165 9.33301C18.165 10.022 18.1657 10.5791 18.1289 11.0293C18.0961 11.4302 18.0311 11.7914 17.8867 12.1279L17.8203 12.2705C17.5549 12.7914 17.1509 13.2272 16.6553 13.5313L16.4365 13.6533C16.0599 13.8452 15.6541 13.9245 15.1963 13.9619C14.8593 13.9895 14.4624 13.9935 13.9951 13.9951C13.9935 14.4624 13.9895 14.8593 13.9619 15.1963C13.9292 15.597 13.864 15.9576 13.7197 16.2939L13.6533 16.4365C13.3878 16.9576 12.9841 17.3941 12.4883 17.6982L12.2705 17.8203C11.8937 18.0123 11.4873 18.0915 11.0293 18.1289C10.5791 18.1657 10.022 18.165 9.33301 18.165H6.5C5.81091 18.165 5.25395 18.1657 4.80371 18.1289C4.40306 18.0962 4.04235 18.031 3.70606 17.8867L3.56348 17.8203C3.04244 17.5548 2.60585 17.151 2.30176 16.6553L2.17969 16.4365C1.98788 16.0599 1.90851 15.6541 1.87109 15.1963C1.83431 14.746 1.83496 14.1891 1.83496 13.5V10.667C1.83496 9.978 1.83432 9.42091 1.87109 8.9707C1.90851 8.5127 1.98772 8.10625 2.17969 7.72949L2.30176 7.51172C2.60586 7.0159 3.04236 6.6122 3.56348 6.34668L3.70606 6.28027C4.04237 6.136 4.40303 6.07083 4.80371 6.03809C5.14051 6.01057 5.53708 6.00551 6.00391 6.00391C6.00551 5.53708 6.01057 5.14051 6.03809 4.80371C6.0755 4.34588 6.15483 3.94012 6.34668 3.56348L6.46875 3.34473C6.77282 2.84912 7.20856 2.44514 7.72949 2.17969L7.87207 2.11328C8.20855 1.96886 8.56979 1.90385 8.9707 1.87109C9.42091 1.83432 9.978 1.83496 10.667 1.83496H13.5C14.1891 1.83496 14.746 1.83431 15.1963 1.87109C15.6541 1.90851 16.0599 1.98788 16.4365 2.17969L16.6553 2.30176C17.151 2.60585 17.5548 3.04244 17.8203 3.56348L17.8867 3.70606C18.031 4.04235 18.0962 4.40306 18.1289 4.80371C18.1657 5.25395 18.165 5.81091 18.165 6.5V9.33301Z\"\u003e\u003c\/path\u003e\u003c\/svg\u003e\u003c\/button\u003e\u003c\/span\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr data-end=\"3000\" data-start=\"2997\"\u003e\n\u003ch4 data-end=\"3038\" data-start=\"3002\"\u003e4 Selectivity and Toxicology\u003c\/h4\u003e\n\u003cul data-end=\"3578\" data-start=\"3040\"\u003e\n\u003cli data-end=\"3207\" data-start=\"3040\"\u003e\n\u003cp data-end=\"3207\" data-start=\"3042\"\u003e\u003cstrong data-end=\"3076\" data-start=\"3042\"\u003eMaximum tolerated dose (mouse)\u003c\/strong\u003e: 2 mg day⁻¹ IP for 28 d with no weight loss, behavioural changes or gross-organ toxicity.\u003cspan data-state=\"closed\" class=\"\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"3379\" data-start=\"3208\"\u003e\n\u003cp data-end=\"3379\" data-start=\"3210\"\u003e\u003cstrong data-end=\"3232\" data-start=\"3210\"\u003eNormal-cell window\u003c\/strong\u003e: Fibroblasts, endothelial cells, PBMCs and marrow progenitors withstand ≥10× tumour-lytic concentrations.\u003cspan data-state=\"closed\" class=\"\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"3578\" data-start=\"3380\"\u003e\n\u003cp data-end=\"3578\" data-start=\"3382\"\u003e\u003cstrong data-end=\"3400\" data-start=\"3382\"\u003eOpen questions\u003c\/strong\u003e: No GLP repeat-dose, reproductive or large-animal studies; immunogenicity is uncharacterised; systemic inflammatory sequelae of extensive tumour necrosis have not been modelled.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-end=\"3583\" data-start=\"3580\"\u003e\n\u003ch4 data-end=\"3634\" data-start=\"3585\"\u003e5 Pharmaceutical and Manufacturing Issues\u003c\/h4\u003e\n\u003cdiv class=\"_tableContainer_80l1q_1\"\u003e\n\u003cdiv class=\"_tableWrapper_80l1q_14 group flex w-fit flex-col-reverse\" tabindex=\"-1\"\u003e\n\u003ctable class=\"w-fit min-w-(--thread-content-width)\" data-end=\"4384\" data-start=\"3636\"\u003e\n\u003cthead data-end=\"3680\" data-start=\"3636\"\u003e\n\u003ctr data-end=\"3680\" data-start=\"3636\"\u003e\n\u003cth data-col-size=\"sm\" data-end=\"3648\" data-start=\"3636\"\u003eChallenge\u003c\/th\u003e\n\u003cth data-col-size=\"lg\" data-end=\"3665\" data-start=\"3648\"\u003eCurrent status\u003c\/th\u003e\n\u003cth data-col-size=\"md\" data-end=\"3680\" data-start=\"3665\"\u003eConsequence\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody data-end=\"4384\" data-start=\"3725\"\u003e\n\u003ctr data-end=\"3905\" data-start=\"3725\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"3753\" data-start=\"3725\"\u003e\u003cstrong data-end=\"3752\" data-start=\"3727\"\u003eProteolytic stability\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"lg\" data-end=\"3844\" data-start=\"3753\"\u003eSerum half-life predicted \u0026lt;10 min; no PEGylated or liposomal formulations yet published.\u003c\/td\u003e\n\u003ctd data-col-size=\"md\" data-end=\"3905\" data-start=\"3844\"\u003eMay require continuous infusion or nano-carrier delivery.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"4167\" data-start=\"3906\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"3928\" data-start=\"3906\"\u003e\u003cstrong data-end=\"3927\" data-start=\"3908\"\u003eSterility \u0026amp; GMP\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"lg\" data-end=\"4087\" data-start=\"3928\"\u003eFDA found \u003cem data-end=\"3962\" data-start=\"3940\"\u003eVariovorax paradoxus\u003c\/em\u003e (Jan 2017) and \u003cem data-end=\"3999\" data-start=\"3978\"\u003eRalstonia insidiosa\u003c\/em\u003e (Mar 2017) in retail “PNC-27 inhalation” vials.\u003cspan data-state=\"closed\" class=\"\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\n\u003c\/td\u003e\n\u003ctd data-col-size=\"md\" data-end=\"4167\" data-start=\"4087\"\u003eDemonstrates urgent need for GMP production and validated endotoxin testing.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-end=\"4384\" data-start=\"4168\"\u003e\n\u003ctd data-col-size=\"sm\" data-end=\"4196\" data-start=\"4168\"\u003e\u003cstrong data-end=\"4195\" data-start=\"4170\"\u003eScale-up \u0026amp; IP freedom\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-col-size=\"lg\" data-end=\"4326\" data-start=\"4196\"\u003eCore sequence protected under WO2009070650A1 until at least 2029 in major jurisdictions.\u003cspan data-state=\"closed\" class=\"\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\n\u003c\/td\u003e\n\u003ctd data-col-size=\"md\" data-end=\"4384\" data-start=\"4326\"\u003eCommercial developers must license or wait for expiry.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cdiv class=\"sticky end-(--thread-content-margin) h-0 self-end select-none\"\u003e\n\u003cdiv class=\"absolute end-0 flex items-end\"\u003e\u003cspan data-state=\"closed\" class=\"\"\u003e\u003cbutton class=\"hover:bg-token-bg-tertiary text-token-text-secondary my-1 rounded-sm p-1 transition-opacity group-[:not(:hover):not(:focus-within)]:pointer-events-none group-[:not(:hover):not(:focus-within)]:opacity-0\" aria-label=\"Tabel kopiëren\"\u003e\u003csvg class=\"icon\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"currentColor\" viewbox=\"0 0 20 20\" height=\"20\" width=\"20\"\u003e\u003cpath d=\"M12.668 10.667C12.668 9.95614 12.668 9.46258 12.6367 9.0791C12.6137 8.79732 12.5758 8.60761 12.5244 8.46387L12.4688 8.33399C12.3148 8.03193 12.0803 7.77885 11.793 7.60254L11.666 7.53125C11.508 7.45087 11.2963 7.39395 10.9209 7.36328C10.5374 7.33197 10.0439 7.33203 9.33301 7.33203H6.5C5.78896 7.33203 5.29563 7.33195 4.91211 7.36328C4.63016 7.38632 4.44065 7.42413 4.29688 7.47559L4.16699 7.53125C3.86488 7.68518 3.61186 7.9196 3.43555 8.20703L3.36524 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2.17969L7.87207 2.11328C8.20855 1.96886 8.56979 1.90385 8.9707 1.87109C9.42091 1.83432 9.978 1.83496 10.667 1.83496H13.5C14.1891 1.83496 14.746 1.83431 15.1963 1.87109C15.6541 1.90851 16.0599 1.98788 16.4365 2.17969L16.6553 2.30176C17.151 2.60585 17.5548 3.04244 17.8203 3.56348L17.8867 3.70606C18.031 4.04235 18.0962 4.40306 18.1289 4.80371C18.1657 5.25395 18.165 5.81091 18.165 6.5V9.33301Z\"\u003e\u003c\/path\u003e\u003c\/svg\u003e\u003c\/button\u003e\u003c\/span\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr data-end=\"4389\" data-start=\"4386\"\u003e\n\u003ch4 data-end=\"4431\" data-start=\"4391\"\u003e6 Regulatory and Legal Landscape\u003c\/h4\u003e\n\u003cul data-end=\"4981\" data-start=\"4433\"\u003e\n\u003cli data-end=\"4621\" data-start=\"4433\"\u003e\n\u003cp data-end=\"4621\" data-start=\"4435\"\u003e\u003cstrong data-end=\"4449\" data-start=\"4435\"\u003eFDA status\u003c\/strong\u003e: No INDs or authorised clinical trials; 2017 FDA alert classifies PNC-27 as an unapproved drug and highlights contamination risks.\u003cspan data-state=\"closed\" class=\"\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"4842\" data-start=\"4622\"\u003e\n\u003cp data-end=\"4842\" data-start=\"4624\"\u003e\u003cstrong data-end=\"4648\" data-start=\"4624\"\u003eCriminal enforcement\u003c\/strong\u003e: \u003cem data-end=\"4674\" data-start=\"4650\"\u003eU.S. v. Patrick Bishop\u003c\/em\u003e (2021) – guilty plea for manufacturing and interstate sale of misbranded PNC-27 products made in a domestic kitchen\/warehouse.\u003cspan data-state=\"closed\" class=\"\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003ca class=\"flex h-4.5 overflow-hidden rounded-xl px-2 text-[9px] font-medium text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! transition-colors duration-150 ease-in-out\" alt=\"https:\/\/www.justice.gov\/usao-ndal\/pr\/birmingham-man-pleads-guilty-conspiracy-making-unapproved-drug-products-his-kitchen-and?utm_source=chatgpt.com\" rel=\"noopener\" href=\"https:\/\/www.justice.gov\/usao-ndal\/pr\/birmingham-man-pleads-guilty-conspiracy-making-unapproved-drug-products-his-kitchen-and?utm_source=chatgpt.com\" target=\"_blank\"\u003e\u003cspan class=\"relative start-0 bottom-0 flex h-full w-full items-center\"\u003e\u003cspan class=\"flex h-4 w-full items-center justify-between overflow-hidden\"\u003e\u003cspan class=\"max-w-full grow truncate overflow-hidden text-center\"\u003ej\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"4981\" data-start=\"4843\"\u003e\n\u003cp data-end=\"4981\" data-start=\"4845\"\u003e\u003cstrong data-end=\"4865\" data-start=\"4845\"\u003eMarketing abuses\u003c\/strong\u003e: Multiple websites still purport “overseas clinical success” but provide no registry numbers or peer-reviewed data.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-end=\"4986\" data-start=\"4983\"\u003e\n\u003ch4 data-end=\"5042\" data-start=\"4988\"\u003e7 Critical Knowledge Gaps Blocking Translation\u003c\/h4\u003e\n\u003col data-end=\"5537\" data-start=\"5044\"\u003e\n\u003cli data-end=\"5112\" data-start=\"5044\"\u003e\n\u003cp data-end=\"5112\" data-start=\"5047\"\u003e\u003cstrong data-end=\"5088\" data-start=\"5047\"\u003eHuman pharmacokinetics and metabolism\u003c\/strong\u003e are wholly undefined.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"5207\" data-start=\"5113\"\u003e\n\u003cp data-end=\"5207\" data-start=\"5116\"\u003e\u003cstrong data-end=\"5134\" data-start=\"5116\"\u003eImmunogenicity\u003c\/strong\u003e of repeated dosing and risk of neutralising antibodies remain unknown.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"5335\" data-start=\"5208\"\u003e\n\u003cp data-end=\"5335\" data-start=\"5211\"\u003e\u003cstrong data-end=\"5242\" data-start=\"5211\"\u003eHDM-2 expression plasticity\u003c\/strong\u003e under stress (infection, hypoxia, chemotherapy) may narrow the therapeutic window in vivo.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"5445\" data-start=\"5336\"\u003e\n\u003cp data-end=\"5445\" data-start=\"5339\"\u003e\u003cstrong data-end=\"5363\" data-start=\"5339\"\u003eResistance evolution\u003c\/strong\u003e – long-term exposure might select HDM-2-negative tumour clones; no studies yet.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"5537\" data-start=\"5446\"\u003e\n\u003cp data-end=\"5537\" data-start=\"5449\"\u003e\u003cstrong data-end=\"5474\" data-start=\"5449\"\u003eCompanion diagnostics\u003c\/strong\u003e to stratify patients by membrane HDM-2 expression are lacking.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003chr data-end=\"5542\" data-start=\"5539\"\u003e\n\u003ch4 data-end=\"5591\" data-start=\"5544\"\u003e8 Roadmap to First-in-Human Development\u003c\/h4\u003e\n\u003col data-end=\"6235\" data-start=\"5593\"\u003e\n\u003cli data-end=\"5717\" data-start=\"5593\"\u003e\n\u003cp data-end=\"5717\" data-start=\"5596\"\u003e\u003cstrong data-end=\"5615\" data-start=\"5596\"\u003eGMP manufacture\u003c\/strong\u003e with validated identity, purity, sterility and endotoxin profiles to resolve past quality failures.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"5848\" data-start=\"5718\"\u003e\n\u003cp data-end=\"5848\" data-start=\"5721\"\u003e\u003cstrong data-end=\"5739\" data-start=\"5721\"\u003eGLP toxicology\u003c\/strong\u003e in rodents and a non-rodent (e.g., canine) model, including repeat-dose and safety-pharmacology endpoints.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"6004\" data-start=\"5849\"\u003e\n\u003cp data-end=\"6004\" data-start=\"5852\"\u003e\u003cstrong data-end=\"5876\" data-start=\"5852\"\u003ePhase I trial design\u003c\/strong\u003e: dose-escalation in refractory solid tumours or AML with confirmed high membrane HDM-2; intensive PK and cytokine monitoring.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"6098\" data-start=\"6005\"\u003e\n\u003cp data-end=\"6098\" data-start=\"6008\"\u003e\u003cstrong data-end=\"6036\" data-start=\"6008\"\u003eImaging or IHC biomarker\u003c\/strong\u003e for membrane HDM-2 to guide enrolment and pharmacodynamics.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"6235\" data-start=\"6099\"\u003e\n\u003cp data-end=\"6235\" data-start=\"6102\"\u003e\u003cstrong data-end=\"6125\" data-start=\"6102\"\u003eCombination cohorts\u003c\/strong\u003e with paclitaxel or platinum agents to validate pre-clinical synergy.\u003cspan data-state=\"closed\" class=\"\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003chr data-end=\"6240\" data-start=\"6237\"\u003e\n\u003ch4 data-end=\"6271\" data-start=\"6242\"\u003e9 Balanced Assessment\u003c\/h4\u003e\n\u003cp data-end=\"6905\" data-start=\"6273\"\u003ePNC-27 delivers a \u003cstrong data-end=\"6356\" data-start=\"6291\"\u003emechanistically elegant, membrane-targeted oncolytic strategy\u003c\/strong\u003e that bypasses p53 status and chemosensitivity. Laboratory evidence demonstrates rapid, selective destruction of a wide spectrum of cancer cells, including chemo-resistant populations, with a large in-vitro therapeutic index. Conversely, the peptide has \u003cstrong data-end=\"6744\" data-start=\"6610\"\u003eno human pharmacology, no GLP toxicology, and a documented history of contaminated grey-market products and regulatory enforcement\u003c\/strong\u003e. Until rigorous manufacturing and clinical studies are completed, PNC-27 remains an intriguing but unvalidated research lead rather than a viable therapeutic.\u003c\/p\u003e\n\u003chr data-end=\"6910\" data-start=\"6907\"\u003e\n\u003ch3 data-end=\"6928\" data-start=\"6912\"\u003eReferences\u003c\/h3\u003e\n\u003col data-end=\"8308\" data-start=\"6930\"\u003e\n\u003cli data-end=\"7143\" data-start=\"6930\"\u003e\n\u003cp data-end=\"7143\" data-start=\"6933\"\u003eYefet L et al. \u003cem data-end=\"7072\" data-start=\"6948\"\u003ePNC-27, a chimeric p53-penetratin peptide binds to HDM-2, induces selective membrane-pore formation and cancer-cell lysis.\u003c\/em\u003e \u003cstrong data-end=\"7089\" data-start=\"7073\"\u003eBiomedicines\u003c\/strong\u003e 2022;10:945.\u003cspan data-state=\"closed\" class=\"\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"7340\" data-start=\"7144\"\u003e\n\u003cp data-end=\"7340\" data-start=\"7147\"\u003eAnnunziata CM et al. \u003cem data-end=\"7263\" data-start=\"7168\"\u003eSynergy between paclitaxel and anti-cancer peptide PNC-27 in the treatment of ovarian cancer.\u003c\/em\u003e \u003cstrong data-end=\"7284\" data-start=\"7264\"\u003eAnn Clin Lab Sci\u003c\/strong\u003e 2017;47:271-9.\u003cspan data-state=\"closed\" class=\"\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"7521\" data-start=\"7341\"\u003e\n\u003cp data-end=\"7521\" data-start=\"7344\"\u003eU.S. FDA. \u003cem data-end=\"7423\" data-start=\"7354\"\u003eFDA warns cancer patients not to use PNC-27 products for treatment.\u003c\/em\u003e Safety Communication, 10 Jan 2017 (updated 27 Mar 2017).\u003cspan data-state=\"closed\" class=\"\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003ca class=\"flex h-4.5 overflow-hidden rounded-xl px-2 text-[9px] font-medium text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! transition-colors duration-150 ease-in-out\" alt=\"https:\/\/www.fda.gov\/drugs\/drug-safety-and-availability\/fda-warns-cancer-patients-not-use-pnc-27-products-treatment?utm_source=chatgpt.com\" rel=\"noopener\" href=\"https:\/\/www.fda.gov\/drugs\/drug-safety-and-availability\/fda-warns-cancer-patients-not-use-pnc-27-products-treatment?utm_source=chatgpt.com\" target=\"_blank\"\u003e\u003cspan class=\"relative start-0 bottom-0 flex h-full w-full items-center\"\u003e\u003cspan class=\"flex h-4 w-full items-center justify-between overflow-hidden\"\u003e\u003cspan class=\"max-w-full grow truncate overflow-hidden text-center\"\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"7732\" data-start=\"7522\"\u003e\n\u003cp data-end=\"7732\" data-start=\"7525\"\u003eU.S. Department of Justice. \u003cem data-end=\"7663\" data-start=\"7553\"\u003eBirmingham man pleads guilty to conspiracy for making unapproved drug products in his kitchen and warehouse.\u003c\/em\u003e Press release, 21 Jan 2021.\u003cspan data-state=\"closed\" class=\"\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"7928\" data-start=\"7733\"\u003e\n\u003cp data-end=\"7928\" data-start=\"7736\"\u003eHall DJ et al. \u003cem data-end=\"7848\" data-start=\"7751\"\u003eSmall-molecule cancer treatments that cause pore formation leading to necrosis of cancer cells.\u003c\/em\u003eWO2009070650A1 (international patent).\u003cspan data-state=\"closed\" class=\"\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"8106\" data-start=\"7929\"\u003e\n\u003cp data-end=\"8106\" data-start=\"7932\"\u003eLi X et al. \u003cem data-end=\"8033\" data-start=\"7944\"\u003eTargeting cell-membrane HDM2: a novel therapeutic approach for acute myeloid leukaemia.\u003c\/em\u003e \u003cstrong data-end=\"8052\" data-start=\"8034\"\u003eCell Death Dis\u003c\/strong\u003e 2021;12:298.\u003cspan data-state=\"closed\" class=\"\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"8308\" data-start=\"8107\"\u003e\n\u003cp data-end=\"8308\" data-start=\"8110\"\u003eSarraf G et al. \u003cem data-end=\"8224\" data-start=\"8126\"\u003ePNC-27 adopts an HDM-2-binding conformation and induces selective membranolysis of cancer cells.\u003c\/em\u003e \u003cstrong data-end=\"8251\" data-start=\"8225\"\u003eProc Natl Acad Sci USA\u003c\/strong\u003e 2009;106:20352-7.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"RCpeptides","offers":[{"title":"Default Title","offer_id":52684855804242,"sku":null,"price":100.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1048\/0956\/2450\/files\/pnc-27_10mg.png?v=1770834884","url":"https:\/\/sciencepeptideslab.com\/products\/pnc-27-10mg-vial","provider":"Science Peptides Lab","version":"1.0","type":"link"}