{"product_id":"slu-pp-332-5mg-vial","title":"SLU-pp-332 10mg vial","description":"\u003cp style=\"text-align: center;\"\u003e\u003cstrong\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cspan style=\"color: rgb(255, 42, 0); text-decoration: underline;\"\u003eN\u003c\/span\u003e\u003c\/span\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cspan style=\"color: rgb(255, 42, 0); text-decoration: underline;\"\u003eOT FOR HUMAN CONSUMPTION\u003cmeta charset=\"UTF-8\"\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-start=\"44\" data-end=\"757\"\u003e\u003cstrong\u003eSLU-PP-332 \u003c\/strong\u003eis a small-molecule \u003cstrong data-start=\"108\" data-end=\"165\"\u003epan–estrogen-related receptor (ERR) agonist\/modulator\u003c\/strong\u003e reported by researchers at Saint Louis University as a pharmacologic \u003cstrong data-start=\"235\" data-end=\"258\"\u003e“exercise mimetic.”\u003c\/strong\u003e By activating \u003cstrong data-start=\"273\" data-end=\"299\"\u003eERRα\/β\/γ (NR3B family)\u003c\/strong\u003e—transcription factors that partner with \u003cstrong data-start=\"340\" data-end=\"350\"\u003ePGC-1α\u003c\/strong\u003e—SLU-PP-332 up-regulates programs for \u003cstrong data-start=\"388\" data-end=\"484\"\u003emitochondrial biogenesis, fatty-acid oxidation (FAO), and oxidative phosphorylation (OXPHOS)\u003c\/strong\u003e. In diet-induced-obese mice, the compound has been described to \u003cstrong data-start=\"549\" data-end=\"591\"\u003eincrease whole-body energy expenditure\u003c\/strong\u003e, \u003cstrong data-start=\"593\" data-end=\"614\"\u003elimit weight gain\u003c\/strong\u003e, and \u003cstrong data-start=\"620\" data-end=\"649\"\u003eimprove glucose tolerance\u003c\/strong\u003e without requiring additional exercise. It is \u003cstrong data-start=\"695\" data-end=\"719\"\u003enot FDA\/EMA-approved\u003c\/strong\u003e; available data are \u003cstrong data-start=\"740\" data-end=\"756\"\u003epre-clinical\u003c\/strong\u003e.\u003c\/p\u003e\n\u003chr data-start=\"759\" data-end=\"762\"\u003e\n\u003ch3 data-start=\"764\" data-end=\"825\"\u003eAdditional Benefits of SLU-PP-332 Now Under Investigation\u003c\/h3\u003e\n\u003cdiv class=\"_tableContainer_sk2ct_1\"\u003e\n\u003cdiv class=\"_tableWrapper_sk2ct_13 group flex w-fit flex-col-reverse\" tabindex=\"-1\"\u003e\n\u003ctable data-start=\"827\" data-end=\"3030\" class=\"w-fit min-w-(--thread-content-width)\"\u003e\n\u003cthead data-start=\"827\" data-end=\"855\"\u003e\n\u003ctr data-start=\"827\" data-end=\"855\"\u003e\n\u003cth data-start=\"827\" data-end=\"837\" data-col-size=\"md\"\u003eBenefit\u003c\/th\u003e\n\u003cth data-start=\"837\" data-end=\"855\" data-col-size=\"xl\"\u003eKey take-aways\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody data-start=\"866\" data-end=\"3030\"\u003e\n\u003ctr data-start=\"866\" data-end=\"1144\"\u003e\n\u003ctd data-start=\"866\" data-end=\"910\" data-col-size=\"md\"\u003e\u003cstrong data-start=\"868\" data-end=\"909\"\u003e1 Energy-expenditure \u0026amp; weight control\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"910\" data-end=\"1144\" data-col-size=\"xl\"\u003eIn obese mice, SLU-PP-332 \u003cstrong data-start=\"938\" data-end=\"955\"\u003eraises VO₂\/EE\u003c\/strong\u003e and \u003cstrong data-start=\"960\" data-end=\"981\"\u003ereduces adiposity\u003c\/strong\u003e largely \u003cstrong data-start=\"990\" data-end=\"1020\"\u003eindependent of food intake\u003c\/strong\u003e, aligning with ERR-driven oxidative remodeling. \u0026lt;br\/\u0026gt;\u0026lt;em\u0026gt;bioRxiv preprint (SLU group); Cell Metabolism (ERR biology)\u0026lt;\/em\u0026gt;\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"1145\" data-end=\"1399\"\u003e\n\u003ctd data-start=\"1145\" data-end=\"1193\" data-col-size=\"md\"\u003e\u003cstrong data-start=\"1147\" data-end=\"1192\"\u003e2 Glycaemic control \u0026amp; insulin sensitivity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"1193\" data-end=\"1399\" data-col-size=\"xl\"\u003eImproves \u003cstrong data-start=\"1204\" data-end=\"1225\"\u003eglucose tolerance\u003c\/strong\u003e and \u003cstrong data-start=\"1230\" data-end=\"1251\"\u003einsulin tolerance\u003c\/strong\u003e with increased skeletal-muscle \u003cstrong data-start=\"1283\" data-end=\"1290\"\u003eAkt\u003c\/strong\u003e signalling and reduced hepatic lipogenesis. \u0026lt;br\/\u0026gt;\u0026lt;em\u0026gt;bioRxiv preprint; Diabetes (mechanistic context)\u0026lt;\/em\u0026gt;\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"1400\" data-end=\"1671\"\u003e\n\u003ctd data-start=\"1400\" data-end=\"1436\" data-col-size=\"md\"\u003e\u003cstrong data-start=\"1402\" data-end=\"1435\"\u003e3 Endurance\/fitness phenotype\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"1436\" data-end=\"1671\" data-col-size=\"xl\"\u003eIn treadmill assays, treated mice exhibit \u003cstrong data-start=\"1480\" data-end=\"1509\"\u003elonger time-to-exhaustion\u003c\/strong\u003e and greater \u003cstrong data-start=\"1522\" data-end=\"1542\"\u003erunning distance\u003c\/strong\u003e, consistent with \u003cstrong data-start=\"1560\" data-end=\"1574\"\u003ePGC-1α\/ERR\u003c\/strong\u003e endurance programs. \u0026lt;br\/\u0026gt;\u0026lt;em\u0026gt;bioRxiv preprint; Journal of Physiology (PGC-1α\/ERR context)\u0026lt;\/em\u0026gt;\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"1672\" data-end=\"1896\"\u003e\n\u003ctd data-start=\"1672\" data-end=\"1698\" data-col-size=\"md\"\u003e\u003cstrong data-start=\"1674\" data-end=\"1697\"\u003e4 Hepatic steatosis\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"1698\" data-end=\"1896\" data-col-size=\"xl\"\u003eDown-regulates \u003cstrong data-start=\"1715\" data-end=\"1731\"\u003eSREBP1c\/FASN\u003c\/strong\u003e and up-regulates \u003cstrong data-start=\"1749\" data-end=\"1772\"\u003eCPT1A\/PPARα targets\u003c\/strong\u003e, reducing \u003cstrong data-start=\"1783\" data-end=\"1806\"\u003eliver triglycerides\u003c\/strong\u003e in NAFLD models. \u0026lt;br\/\u0026gt;\u0026lt;em\u0026gt;bioRxiv preprint; Hepatology (ERR in hepatic lipid flux)\u0026lt;\/em\u0026gt;\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"1897\" data-end=\"2150\"\u003e\n\u003ctd data-start=\"1897\" data-end=\"1930\" data-col-size=\"md\"\u003e\u003cstrong data-start=\"1899\" data-end=\"1929\"\u003e5 Mitochondrial biogenesis\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"1930\" data-end=\"2150\" data-col-size=\"xl\"\u003eIncreases \u003cstrong data-start=\"1942\" data-end=\"1963\"\u003emtDNA copy number\u003c\/strong\u003e, \u003cstrong data-start=\"1965\" data-end=\"1994\"\u003eOXPHOS complex expression\u003c\/strong\u003e, and \u003cstrong data-start=\"2000\" data-end=\"2010\"\u003ePGC-1α\u003c\/strong\u003e target genes in muscle and brown\/brite fat. \u0026lt;br\/\u0026gt;\u0026lt;em\u0026gt;bioRxiv preprint; Nature Reviews Molecular Cell Biology (mitochondrial control)\u0026lt;\/em\u0026gt;\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"2151\" data-end=\"2383\"\u003e\n\u003ctd data-start=\"2151\" data-end=\"2189\" data-col-size=\"md\"\u003e\u003cstrong data-start=\"2153\" data-end=\"2188\"\u003e6 WAT browning \u0026amp; BAT activation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"2189\" data-end=\"2383\" data-col-size=\"xl\"\u003eInduces \u003cstrong data-start=\"2199\" data-end=\"2207\"\u003eUCP1\u003c\/strong\u003e, \u003cstrong data-start=\"2209\" data-end=\"2217\"\u003eDIO2\u003c\/strong\u003e, and thermogenic genes with \u003cstrong data-start=\"2246\" data-end=\"2272\"\u003esmaller adipocyte size\u003c\/strong\u003e, pointing to beige fat recruitment. \u0026lt;br\/\u0026gt;\u0026lt;em\u0026gt;bioRxiv preprint; Molecular Metabolism (ERR thermogenesis)\u0026lt;\/em\u0026gt;\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"2384\" data-end=\"2603\"\u003e\n\u003ctd data-start=\"2384\" data-end=\"2416\" data-col-size=\"md\"\u003e\u003cstrong data-start=\"2386\" data-end=\"2415\"\u003e7 Anti-inflammatory shift\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"2416\" data-end=\"2603\" data-col-size=\"xl\"\u003eReduces \u003cstrong data-start=\"2426\" data-end=\"2440\"\u003eTNF-α\/IL-6\u003c\/strong\u003e and \u003cstrong data-start=\"2445\" data-end=\"2470\"\u003ecrown-like structures\u003c\/strong\u003e in adipose tissue, aligning with improved insulin signalling. \u0026lt;br\/\u0026gt;\u0026lt;em\u0026gt;bioRxiv preprint; Cardiovascular Diabetology (context)\u0026lt;\/em\u0026gt;\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"2604\" data-end=\"2815\"\u003e\n\u003ctd data-start=\"2604\" data-end=\"2632\" data-col-size=\"md\"\u003e\u003cstrong data-start=\"2606\" data-end=\"2631\"\u003e8 Exercise additivity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"2632\" data-end=\"2815\" data-col-size=\"xl\"\u003e\n\u003cstrong data-start=\"2634\" data-end=\"2655\"\u003eAdditive benefits\u003c\/strong\u003e when layered on voluntary running—higher oxidative gene expression and endurance than either alone. \u0026lt;br\/\u0026gt;\u0026lt;em\u0026gt;bioRxiv preprint; Exercise-genomics reviews\u0026lt;\/em\u0026gt;\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"2816\" data-end=\"3030\"\u003e\n\u003ctd data-start=\"2816\" data-end=\"2857\" data-col-size=\"md\"\u003e\u003cstrong data-start=\"2818\" data-end=\"2856\"\u003e9 Lipids \u0026amp; cardiometabolic profile\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"2857\" data-end=\"3030\" data-col-size=\"xl\"\u003eLowers \u003cstrong data-start=\"2866\" data-end=\"2882\"\u003eplasma TG\/TC\u003c\/strong\u003e and improves \u003cstrong data-start=\"2896\" data-end=\"2906\"\u003eHDL:TG\u003c\/strong\u003e ratios in rodents; human relevance pending. \u0026lt;br\/\u0026gt;\u0026lt;em\u0026gt;bioRxiv preprint; Journal of Lipid Research (ERR lipid biology)\u0026lt;\/em\u0026gt;\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr data-start=\"3032\" data-end=\"3035\"\u003e\n\u003ch2 data-start=\"3037\" data-end=\"3072\"\u003e2. Molecular Mechanism of Action\u003c\/h2\u003e\n\u003ch3 data-start=\"3074\" data-end=\"3107\"\u003e2.1 Target Pharmacodynamics\u003c\/h3\u003e\n\u003cul data-start=\"3108\" data-end=\"3573\"\u003e\n\u003cli data-start=\"3108\" data-end=\"3237\"\u003e\n\u003cp data-start=\"3110\" data-end=\"3237\"\u003e\u003cstrong data-start=\"3110\" data-end=\"3130\"\u003ePrimary targets:\u003c\/strong\u003e \u003cstrong data-start=\"3131\" data-end=\"3143\"\u003eERRα\/β\/γ\u003c\/strong\u003e nuclear receptors (constitutive transcription factors) that are \u003cstrong data-start=\"3208\" data-end=\"3234\"\u003eco-activated by PGC-1α\u003c\/strong\u003e.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"3238\" data-end=\"3446\"\u003e\n\u003cp data-start=\"3240\" data-end=\"3446\"\u003e\u003cstrong data-start=\"3240\" data-end=\"3262\"\u003eSLU-PP-332 action:\u003c\/strong\u003e \u003cstrong data-start=\"3263\" data-end=\"3317\"\u003eStabilizes\/activates ERR transcriptional complexes\u003c\/strong\u003e, increasing transcription of \u003cstrong data-start=\"3347\" data-end=\"3375\"\u003eFAO\/OXPHOS\/mitochondrial\u003c\/strong\u003e genes across oxidative tissues (skeletal muscle, heart, BAT, liver).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"3447\" data-end=\"3573\"\u003e\n\u003cp data-start=\"3449\" data-end=\"3573\"\u003e\u003cstrong data-start=\"3449\" data-end=\"3473\"\u003ePhysiologic analogy:\u003c\/strong\u003e Mimics transcriptional changes seen after \u003cstrong data-start=\"3516\" data-end=\"3538\"\u003eendurance exercise\u003c\/strong\u003e or \u003cstrong data-start=\"3542\" data-end=\"3572\"\u003ecold-induced thermogenesis\u003c\/strong\u003e.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3 data-start=\"3575\" data-end=\"3602\"\u003e2.2 Down-stream Biology\u003c\/h3\u003e\n\u003cdiv class=\"_tableContainer_sk2ct_1\"\u003e\n\u003cdiv class=\"_tableWrapper_sk2ct_13 group flex w-fit flex-col-reverse\" tabindex=\"-1\"\u003e\n\u003ctable data-start=\"3604\" data-end=\"4189\" class=\"w-fit min-w-(--thread-content-width)\"\u003e\n\u003cthead data-start=\"3604\" data-end=\"3646\"\u003e\n\u003ctr data-start=\"3604\" data-end=\"3646\"\u003e\n\u003cth data-start=\"3604\" data-end=\"3614\" data-col-size=\"sm\"\u003ePathway\u003c\/th\u003e\n\u003cth data-start=\"3614\" data-end=\"3635\" data-col-size=\"md\"\u003eFunctional outcome\u003c\/th\u003e\n\u003cth data-start=\"3635\" data-end=\"3646\" data-col-size=\"sm\"\u003eContext\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody data-start=\"3661\" data-end=\"4189\"\u003e\n\u003ctr data-start=\"3661\" data-end=\"3779\"\u003e\n\u003ctd data-start=\"3661\" data-end=\"3699\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"3663\" data-end=\"3698\"\u003ePGC-1α–ERR transcriptional axis\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"3699\" data-end=\"3757\" data-col-size=\"md\"\u003e↑ Mitochondrial biogenesis (NRF1\/TFAM), ↑ OXPHOS, ↑ FAO\u003c\/td\u003e\n\u003ctd data-start=\"3757\" data-end=\"3779\" data-col-size=\"sm\"\u003eMuscle, BAT, liver\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"3780\" data-end=\"3885\"\u003e\n\u003ctd data-start=\"3780\" data-end=\"3807\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"3782\" data-end=\"3806\"\u003ePPAR\/AMPK cross-talk\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"3807\" data-end=\"3868\" data-col-size=\"md\"\u003e↑ CPT1A\/ACADs, ↑ lipid oxidation; partial AMPK convergence\u003c\/td\u003e\n\u003ctd data-start=\"3868\" data-end=\"3885\" data-col-size=\"sm\"\u003eLiver, muscle\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"3886\" data-end=\"4001\"\u003e\n\u003ctd data-start=\"3886\" data-end=\"3912\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"3888\" data-end=\"3911\"\u003eMyofiber remodeling\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"3912\" data-end=\"3982\" data-col-size=\"md\"\u003eShift toward oxidative type I\/IIA fibers; ↑ capillary density genes\u003c\/td\u003e\n\u003ctd data-start=\"3982\" data-end=\"4001\" data-col-size=\"sm\"\u003eSkeletal muscle\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"4002\" data-end=\"4089\"\u003e\n\u003ctd data-start=\"4002\" data-end=\"4028\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"4004\" data-end=\"4027\"\u003eThermogenic program\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"4028\" data-end=\"4072\" data-col-size=\"md\"\u003e↑ UCP1\/UCP3, ↑ DIO2, ↑ β-oxidation → ↑ EE\u003c\/td\u003e\n\u003ctd data-start=\"4072\" data-end=\"4089\" data-col-size=\"sm\"\u003eBAT\/brite WAT\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"4090\" data-end=\"4189\"\u003e\n\u003ctd data-start=\"4090\" data-end=\"4113\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"4092\" data-end=\"4112\"\u003eInflammation\/ECM\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"4113\" data-end=\"4172\" data-col-size=\"md\"\u003e↓ Pro-inflammatory cytokines, ↓ adipose fibrosis markers\u003c\/td\u003e\n\u003ctd data-start=\"4172\" data-end=\"4189\" data-col-size=\"sm\"\u003eAdipose\/liver\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr data-start=\"4191\" data-end=\"4194\"\u003e\n\u003ch2 data-start=\"4196\" data-end=\"4218\"\u003e3. Pharmacokinetics\u003c\/h2\u003e\n\u003cul data-start=\"4220\" data-end=\"4728\"\u003e\n\u003cli data-start=\"4220\" data-end=\"4310\"\u003e\n\u003cp data-start=\"4222\" data-end=\"4310\"\u003e\u003cstrong data-start=\"4222\" data-end=\"4237\"\u003eRoute\/form:\u003c\/strong\u003e \u003cstrong data-start=\"4238\" data-end=\"4256\"\u003eSmall-molecule\u003c\/strong\u003e administered to rodents; detailed human PK unknown.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"4311\" data-end=\"4457\"\u003e\n\u003cp data-start=\"4313\" data-end=\"4457\"\u003e\u003cstrong data-start=\"4313\" data-end=\"4326\"\u003eExposure:\u003c\/strong\u003e Pre-clinical reports indicate \u003cstrong data-start=\"4357\" data-end=\"4378\"\u003esystemic exposure\u003c\/strong\u003e compatible with once-daily paradigms in mice; \u003cstrong data-start=\"4425\" data-end=\"4446\"\u003ebrain penetration\u003c\/strong\u003e unclear.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"4458\" data-end=\"4597\"\u003e\n\u003cp data-start=\"4460\" data-end=\"4597\"\u003e\u003cstrong data-start=\"4460\" data-end=\"4484\"\u003eHalf-life\/clearance:\u003c\/strong\u003e Not publicly established; presumed \u003cstrong data-start=\"4520\" data-end=\"4537\"\u003ehepatic\/renal\u003c\/strong\u003e clearance typical of lipophilic transcription-modulators.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"4598\" data-end=\"4728\"\u003e\n\u003cp data-start=\"4600\" data-end=\"4728\"\u003e\u003cstrong data-start=\"4600\" data-end=\"4627\"\u003eDrug–drug interactions:\u003c\/strong\u003e No clinical data; ERRs \u003cstrong data-start=\"4651\" data-end=\"4681\"\u003eregulate metabolic enzymes\u003c\/strong\u003e, so \u003cstrong data-start=\"4686\" data-end=\"4698\"\u003eindirect\u003c\/strong\u003e interactions are conceivable.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-start=\"4730\" data-end=\"4733\"\u003e\n\u003ch2 data-start=\"4735\" data-end=\"4780\"\u003e4. Pre-clinical and Translational Evidence\u003c\/h2\u003e\n\u003ch3 data-start=\"4782\" data-end=\"4820\"\u003e4.1 Obesity \u0026amp; Metabolic Syndrome\u003c\/h3\u003e\n\u003cp data-start=\"4821\" data-end=\"5012\"\u003eDiet-induced-obese mice treated with SLU-PP-332 display \u003cstrong data-start=\"4877\" data-end=\"4897\"\u003eless weight gain\u003c\/strong\u003e, \u003cstrong data-start=\"4899\" data-end=\"4916\"\u003ehigher VO₂\/EE\u003c\/strong\u003e, \u003cstrong data-start=\"4918\" data-end=\"4946\"\u003ebetter glucose tolerance\u003c\/strong\u003e, and \u003cstrong data-start=\"4952\" data-end=\"4974\"\u003esmaller adipocytes\u003c\/strong\u003e, with \u003cstrong data-start=\"4981\" data-end=\"4993\"\u003ebrowning\u003c\/strong\u003e signatures in WAT.\u003c\/p\u003e\n\u003ch3 data-start=\"5014\" data-end=\"5029\"\u003e4.2 NAFLD\u003c\/h3\u003e\n\u003cp data-start=\"5030\" data-end=\"5199\"\u003eLiver transcriptomics show \u003cstrong data-start=\"5057\" data-end=\"5083\"\u003esuppressed lipogenesis\u003c\/strong\u003e and \u003cstrong data-start=\"5088\" data-end=\"5104\"\u003eenhanced FAO\u003c\/strong\u003e, with \u003cstrong data-start=\"5111\" data-end=\"5142\"\u003elower hepatic triglycerides\u003c\/strong\u003e and improved transaminases in models prone to steatosis.\u003c\/p\u003e\n\u003ch3 data-start=\"5201\" data-end=\"5229\"\u003e4.3 Exercise \u0026amp; Fitness\u003c\/h3\u003e\n\u003cp data-start=\"5230\" data-end=\"5406\"\u003eSkeletal muscle exhibits \u003cstrong data-start=\"5255\" data-end=\"5286\"\u003ePGC-1α\/ERR target induction\u003c\/strong\u003e, increased \u003cstrong data-start=\"5298\" data-end=\"5318\"\u003eOXPHOS complexes\u003c\/strong\u003e, and \u003cstrong data-start=\"5324\" data-end=\"5356\"\u003eimproved treadmill endurance\u003c\/strong\u003e—recapitulating aspects of \u003cstrong data-start=\"5383\" data-end=\"5405\"\u003eendurance training\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cblockquote data-start=\"5408\" data-end=\"5630\"\u003e\n\u003cp data-start=\"5410\" data-end=\"5630\"\u003e\u003cstrong data-start=\"5410\" data-end=\"5436\"\u003eEvidence quality note:\u003c\/strong\u003e Data for SLU-PP-332 are \u003cstrong data-start=\"5461\" data-end=\"5493\"\u003epre-clinical (rodents\/cells)\u003c\/strong\u003e and include \u003cstrong data-start=\"5506\" data-end=\"5545\"\u003einstitutional reports and preprints\u003c\/strong\u003e. Peer-reviewed, multicentre replication and \u003cstrong data-start=\"5590\" data-end=\"5607\"\u003ehuman studies\u003c\/strong\u003e are not yet available.\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003chr data-start=\"5632\" data-end=\"5635\"\u003e\n\u003ch2 data-start=\"5637\" data-end=\"5670\"\u003e5. Emerging Clinical Interests\u003c\/h2\u003e\n\u003cdiv class=\"_tableContainer_sk2ct_1\"\u003e\n\u003cdiv class=\"_tableWrapper_sk2ct_13 group flex w-fit flex-col-reverse\" tabindex=\"-1\"\u003e\n\u003ctable data-start=\"5672\" data-end=\"6192\" class=\"w-fit min-w-(--thread-content-width)\"\u003e\n\u003cthead data-start=\"5672\" data-end=\"5710\"\u003e\n\u003ctr data-start=\"5672\" data-end=\"5710\"\u003e\n\u003cth data-start=\"5672\" data-end=\"5680\" data-col-size=\"sm\"\u003eField\u003c\/th\u003e\n\u003cth data-start=\"5680\" data-end=\"5692\" data-col-size=\"md\"\u003eRationale\u003c\/th\u003e\n\u003cth data-start=\"5692\" data-end=\"5710\" data-col-size=\"sm\"\u003eCurrent status\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody data-start=\"5725\" data-end=\"6192\"\u003e\n\u003ctr data-start=\"5725\" data-end=\"5825\"\u003e\n\u003ctd data-start=\"5725\" data-end=\"5750\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"5727\" data-end=\"5749\"\u003eObesity\/overweight\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"5750\" data-end=\"5809\" data-col-size=\"md\"\u003e↑ EE without appetite suppression; oxidative remodelling\u003c\/td\u003e\n\u003ctd data-start=\"5809\" data-end=\"5825\" data-col-size=\"sm\"\u003ePre-clinical\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"5826\" data-end=\"5895\"\u003e\n\u003ctd data-start=\"5826\" data-end=\"5843\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"5828\" data-end=\"5842\"\u003eNAFLD\/NASH\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"5843\" data-end=\"5879\" data-col-size=\"md\"\u003e↓ DNL, ↑ FAO; thermogenic support\u003c\/td\u003e\n\u003ctd data-start=\"5879\" data-end=\"5895\" data-col-size=\"sm\"\u003ePre-clinical\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"5896\" data-end=\"5994\"\u003e\n\u003ctd data-start=\"5896\" data-end=\"5925\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"5898\" data-end=\"5924\"\u003eT2D\/insulin resistance\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"5925\" data-end=\"5978\" data-col-size=\"md\"\u003eImproved insulin signalling \u0026amp; adipose inflammation\u003c\/td\u003e\n\u003ctd data-start=\"5978\" data-end=\"5994\" data-col-size=\"sm\"\u003ePre-clinical\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"5995\" data-end=\"6101\"\u003e\n\u003ctd data-start=\"5995\" data-end=\"6028\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"5997\" data-end=\"6027\"\u003eSarcopenic obesity\/frailty\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"6028\" data-end=\"6083\" data-col-size=\"md\"\u003eEndurance\/mitochondrial programs to augment function\u003c\/td\u003e\n\u003ctd data-start=\"6083\" data-end=\"6101\" data-col-size=\"sm\"\u003eConcept\/rodent\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"6102\" data-end=\"6192\"\u003e\n\u003ctd data-start=\"6102\" data-end=\"6132\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"6104\" data-end=\"6131\"\u003eCardiometabolic fitness\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"6132\" data-end=\"6174\" data-col-size=\"md\"\u003eExercise-mimetic transcriptional shifts\u003c\/td\u003e\n\u003ctd data-start=\"6174\" data-end=\"6192\" data-col-size=\"sm\"\u003eConcept\/rodent\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr data-start=\"6194\" data-end=\"6197\"\u003e\n\u003ch2 data-start=\"6199\" data-end=\"6228\"\u003e6. Safety and Tolerability\u003c\/h2\u003e\n\u003cul data-start=\"6230\" data-end=\"6894\"\u003e\n\u003cli data-start=\"6230\" data-end=\"6287\"\u003e\n\u003cp data-start=\"6232\" data-end=\"6287\"\u003e\u003cstrong data-start=\"6232\" data-end=\"6249\"\u003eHuman safety:\u003c\/strong\u003e \u003cstrong data-start=\"6250\" data-end=\"6261\"\u003eUnknown\u003c\/strong\u003e (no clinical datasets).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"6288\" data-end=\"6495\"\u003e\n\u003cp data-start=\"6290\" data-end=\"6495\"\u003e\u003cstrong data-start=\"6290\" data-end=\"6313\"\u003eOn-target cautions:\u003c\/strong\u003e \u003cstrong data-start=\"6314\" data-end=\"6354\"\u003eERRα\/γ are highly expressed in heart\u003c\/strong\u003e—chronic pan-ERR activation may alter \u003cstrong data-start=\"6392\" data-end=\"6440\"\u003ecardiac energetics\/arrhythmia susceptibility\u003c\/strong\u003e; careful CV monitoring would be required clinically.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"6496\" data-end=\"6624\"\u003e\n\u003cp data-start=\"6498\" data-end=\"6624\"\u003e\u003cstrong data-start=\"6498\" data-end=\"6516\"\u003eEndocrine\/GRN:\u003c\/strong\u003e ERRs cross-talk with \u003cstrong data-start=\"6538\" data-end=\"6563\"\u003eestrogen\/thyroid\/PPAR\u003c\/strong\u003e programs; unintended transcriptional effects are possible.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"6625\" data-end=\"6798\"\u003e\n\u003cp data-start=\"6627\" data-end=\"6798\"\u003e\u003cstrong data-start=\"6627\" data-end=\"6641\"\u003eMetabolic:\u003c\/strong\u003e Excessive EE could \u003cstrong data-start=\"6661\" data-end=\"6704\"\u003eincrease resting heart rate\/temperature\u003c\/strong\u003e; \u003cstrong data-start=\"6706\" data-end=\"6746\"\u003eweight loss without intake reduction\u003c\/strong\u003eraises \u003cstrong data-start=\"6754\" data-end=\"6777\"\u003enutrient deficiency\u003c\/strong\u003e risk if unmanaged.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"6799\" data-end=\"6894\"\u003e\n\u003cp data-start=\"6801\" data-end=\"6894\"\u003e\u003cstrong data-start=\"6801\" data-end=\"6831\"\u003eGenotoxicity\/oncogenicity:\u003c\/strong\u003e No GLP toxicology or carcinogenicity data have been disclosed.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-start=\"6896\" data-end=\"6925\"\u003e\u003cstrong data-start=\"6896\" data-end=\"6925\"\u003eComparative safety matrix\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"_tableContainer_sk2ct_1\"\u003e\n\u003cdiv class=\"_tableWrapper_sk2ct_13 group flex w-fit flex-col-reverse\" tabindex=\"-1\"\u003e\n\u003ctable data-start=\"6927\" data-end=\"7456\" class=\"w-fit min-w-(--thread-content-width)\"\u003e\n\u003cthead data-start=\"6927\" data-end=\"7023\"\u003e\n\u003ctr data-start=\"6927\" data-end=\"7023\"\u003e\n\u003cth data-start=\"6927\" data-end=\"6937\" data-col-size=\"sm\"\u003eConcern\u003c\/th\u003e\n\u003cth data-start=\"6937\" data-end=\"6964\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"6939\" data-end=\"6963\"\u003eSLU-PP-332 (pan-ERR)\u003c\/strong\u003e\u003c\/th\u003e\n\u003cth data-start=\"6964\" data-end=\"6991\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"6966\" data-end=\"6990\"\u003eAICAR (AMPK agonist)\u003c\/strong\u003e\u003c\/th\u003e\n\u003cth data-start=\"6991\" data-end=\"7023\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"6993\" data-end=\"7021\"\u003eGW501516 (PPARδ agonist)\u003c\/strong\u003e\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody data-start=\"7042\" data-end=\"7456\"\u003e\n\u003ctr data-start=\"7042\" data-end=\"7150\"\u003e\n\u003ctd data-start=\"7042\" data-end=\"7054\" data-col-size=\"sm\"\u003eMechanism\u003c\/td\u003e\n\u003ctd data-start=\"7054\" data-end=\"7100\" data-col-size=\"sm\"\u003eTranscriptional “exercise” via \u003cstrong data-start=\"7087\" data-end=\"7099\"\u003eERRα\/β\/γ\u003c\/strong\u003e\n\u003c\/td\u003e\n\u003ctd data-start=\"7100\" data-end=\"7123\" data-col-size=\"sm\"\u003eEnergy stress sensor\u003c\/td\u003e\n\u003ctd data-start=\"7123\" data-end=\"7150\" data-col-size=\"sm\"\u003eFAO\/oxidative via PPARδ\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"7151\" data-end=\"7247\"\u003e\n\u003ctd data-start=\"7151\" data-end=\"7164\" data-col-size=\"sm\"\u003eHuman data\u003c\/td\u003e\n\u003ctd data-start=\"7164\" data-end=\"7175\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"7166\" data-end=\"7174\"\u003eNone\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"7175\" data-end=\"7203\" data-col-size=\"sm\"\u003eLimited (investigational)\u003c\/td\u003e\n\u003ctd data-start=\"7203\" data-end=\"7247\" data-col-size=\"sm\"\u003eNone (rodent tumor signals at high dose)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"7248\" data-end=\"7380\"\u003e\n\u003ctd data-start=\"7248\" data-end=\"7260\" data-col-size=\"sm\"\u003eCV impact\u003c\/td\u003e\n\u003ctd data-start=\"7260\" data-end=\"7302\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"7262\" data-end=\"7301\"\u003ePotential cardiac energetic effects\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"7302\" data-end=\"7338\" data-col-size=\"sm\"\u003eBrady-like signals in some models\u003c\/td\u003e\n\u003ctd data-start=\"7338\" data-end=\"7380\" data-col-size=\"sm\"\u003e↑ endurance; tumor concerns in rodents\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"7381\" data-end=\"7456\"\u003e\n\u003ctd data-start=\"7381\" data-end=\"7401\" data-col-size=\"sm\"\u003eRegulatory status\u003c\/td\u003e\n\u003ctd data-start=\"7401\" data-end=\"7416\" data-col-size=\"sm\"\u003ePre-clinical\u003c\/td\u003e\n\u003ctd data-start=\"7416\" data-end=\"7434\" data-col-size=\"sm\"\u003eInvestigational\u003c\/td\u003e\n\u003ctd data-start=\"7434\" data-end=\"7456\" data-col-size=\"sm\"\u003eAbandoned (safety)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr data-start=\"7458\" data-end=\"7461\"\u003e\n\u003ch2 data-start=\"7463\" data-end=\"7489\"\u003e7. Regulatory Landscape\u003c\/h2\u003e\n\u003cul data-start=\"7491\" data-end=\"7778\"\u003e\n\u003cli data-start=\"7491\" data-end=\"7515\"\u003e\n\u003cp data-start=\"7493\" data-end=\"7515\"\u003e\u003cstrong data-start=\"7493\" data-end=\"7507\"\u003eApprovals:\u003c\/strong\u003e None.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"7516\" data-end=\"7658\"\u003e\n\u003cp data-start=\"7518\" data-end=\"7658\"\u003e\u003cstrong data-start=\"7518\" data-end=\"7540\"\u003eDevelopment stage:\u003c\/strong\u003e \u003cstrong data-start=\"7541\" data-end=\"7588\"\u003eDiscovery\/lead-optimization to pre-clinical\u003c\/strong\u003e space; \u003cstrong data-start=\"7596\" data-end=\"7626\"\u003eno registered human trials\u003c\/strong\u003e publicly reported as of 2025.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"7659\" data-end=\"7778\"\u003e\n\u003cp data-start=\"7661\" data-end=\"7778\"\u003e\u003cstrong data-start=\"7661\" data-end=\"7672\"\u003eAccess:\u003c\/strong\u003e Not available as a medicine; any grey-market product should be considered \u003cstrong data-start=\"7747\" data-end=\"7762\"\u003eunregulated\u003c\/strong\u003e and \u003cstrong data-start=\"7767\" data-end=\"7777\"\u003eunsafe\u003c\/strong\u003e.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-start=\"7780\" data-end=\"7783\"\u003e\n\u003ch2 data-start=\"7785\" data-end=\"7808\"\u003e8. Future Directions\u003c\/h2\u003e\n\u003cul data-start=\"7810\" data-end=\"8612\"\u003e\n\u003cli data-start=\"7810\" data-end=\"7957\"\u003e\n\u003cp data-start=\"7812\" data-end=\"7957\"\u003e\u003cstrong data-start=\"7812\" data-end=\"7840\"\u003eSelectivity engineering:\u003c\/strong\u003e Bias toward \u003cstrong data-start=\"7853\" data-end=\"7863\"\u003eERRα\/γ\u003c\/strong\u003e or tissue-targeted delivery (e.g., \u003cstrong data-start=\"7899\" data-end=\"7929\"\u003emuscle- or liver-targeting\u003c\/strong\u003e) to improve benefit–risk.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"7958\" data-end=\"8130\"\u003e\n\u003cp data-start=\"7960\" data-end=\"8130\"\u003e\u003cstrong data-start=\"7960\" data-end=\"7989\"\u003eTranslational biomarkers:\u003c\/strong\u003e \u003cstrong data-start=\"7990\" data-end=\"8083\"\u003eIndirect calorimetry (VO₂), acyl-carnitine profiles, mtDNA copy number, OXPHOS proteomics\u003c\/strong\u003e, and \u003cstrong data-start=\"8089\" data-end=\"8107\"\u003eliver MRI-PDFF\u003c\/strong\u003e for early human PoC.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"8131\" data-end=\"8279\"\u003e\n\u003cp data-start=\"8133\" data-end=\"8279\"\u003e\u003cstrong data-start=\"8133\" data-end=\"8160\"\u003eCombination strategies:\u003c\/strong\u003e Pair with \u003cstrong data-start=\"8171\" data-end=\"8188\"\u003ediet\/exercise\u003c\/strong\u003e, \u003cstrong data-start=\"8190\" data-end=\"8212\"\u003eGLP-1\/GIP agonists\u003c\/strong\u003e (metabolic) or \u003cstrong data-start=\"8228\" data-end=\"8238\"\u003eSGLT2i\u003c\/strong\u003e to diversify cardiometabolic benefits.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"8280\" data-end=\"8441\"\u003e\n\u003cp data-start=\"8282\" data-end=\"8441\"\u003e\u003cstrong data-start=\"8282\" data-end=\"8301\"\u003eSafety program:\u003c\/strong\u003e \u003cstrong data-start=\"8302\" data-end=\"8331\"\u003eCardiac electrophysiology\u003c\/strong\u003e, \u003cstrong data-start=\"8333\" data-end=\"8359\"\u003emitochondrial toxicity\u003c\/strong\u003e, \u003cstrong data-start=\"8361\" data-end=\"8402\"\u003eoff-target nuclear-receptor profiling\u003c\/strong\u003e, and \u003cstrong data-start=\"8408\" data-end=\"8423\"\u003echronic tox\u003c\/strong\u003e in two species.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"8442\" data-end=\"8612\"\u003e\n\u003cp data-start=\"8444\" data-end=\"8612\"\u003e\u003cstrong data-start=\"8444\" data-end=\"8468\"\u003ePhenotype targeting:\u003c\/strong\u003e Visceral-predominant obesity, \u003cstrong data-start=\"8499\" data-end=\"8525\"\u003eNAFLD with low fitness\u003c\/strong\u003e, and \u003cstrong data-start=\"8531\" data-end=\"8566\"\u003estatin-intolerant dysmetabolism\u003c\/strong\u003e where oxidative re-programming is compelling.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-start=\"8614\" data-end=\"8617\"\u003e\n\u003ch3 data-start=\"8619\" data-end=\"8642\"\u003eSelected References\u003c\/h3\u003e\n\u003cul data-start=\"8644\" data-end=\"9299\"\u003e\n\u003cli data-start=\"8644\" data-end=\"8781\"\u003e\n\u003cp data-start=\"8646\" data-end=\"8781\"\u003eSaint Louis University research communications and preprints describing \u003cstrong data-start=\"8718\" data-end=\"8732\"\u003eSLU-PP-332\u003c\/strong\u003e as a pan-ERR exercise-mimetic (mouse studies).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"8782\" data-end=\"8920\"\u003e\n\u003cp data-start=\"8784\" data-end=\"8920\"\u003e\u003cstrong data-start=\"8784\" data-end=\"8833\"\u003eCell Metabolism; Nature Reviews Endocrinology\u003c\/strong\u003e — Reviews on \u003cstrong data-start=\"8847\" data-end=\"8861\"\u003eERR–PGC-1α\u003c\/strong\u003e control of oxidative metabolism and exercise adaptation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"8921\" data-end=\"9055\"\u003e\n\u003cp data-start=\"8923\" data-end=\"9055\"\u003e\u003cstrong data-start=\"8923\" data-end=\"8974\"\u003eMolecular Metabolism; Journal of Lipid Research\u003c\/strong\u003e — ERR regulation of \u003cstrong data-start=\"8995\" data-end=\"9012\"\u003ethermogenesis\u003c\/strong\u003e and \u003cstrong data-start=\"9017\" data-end=\"9031\"\u003elipid flux\u003c\/strong\u003e in adipose and liver.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"9056\" data-end=\"9192\"\u003e\n\u003cp data-start=\"9058\" data-end=\"9192\"\u003e\u003cstrong data-start=\"9058\" data-end=\"9122\"\u003eJournal of Physiology; Nature Reviews Molecular Cell Biology\u003c\/strong\u003e — \u003cstrong data-start=\"9125\" data-end=\"9135\"\u003ePGC-1α\u003c\/strong\u003e in endurance adaptations and mitochondrial biogenesis.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"9193\" data-end=\"9299\"\u003e\n\u003cp data-start=\"9195\" data-end=\"9299\"\u003e\u003cstrong data-start=\"9195\" data-end=\"9222\"\u003eCardiovascular Research\u003c\/strong\u003e — Cardiac roles of \u003cstrong data-start=\"9242\" data-end=\"9252\"\u003eERRα\/γ\u003c\/strong\u003e and implications for pharmacologic activation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"Mijn winkel","offers":[{"title":"Default Title","offer_id":52684852527442,"sku":null,"price":80.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1048\/0956\/2450\/files\/SLU-pp-332_10mg.png?v=1770834857","url":"https:\/\/sciencepeptideslab.com\/products\/slu-pp-332-5mg-vial","provider":"Science Peptides Lab","version":"1.0","type":"link"}