{"product_id":"survodutide-10mg-vial","title":"Survodutide 10mg vial","description":"\u003ch3\u003e\n\u003cspan style=\"color: rgb(255, 42, 0);\"\u003e\u003cstrong\u003e                                    \u003cspan style=\"text-decoration: underline;\"\u003eNOT \u003c\/span\u003e\u003c\/strong\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cstrong\u003eFOR HUMAN \u003c\/strong\u003e\u003c\/span\u003e\u003c\/span\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cspan style=\"color: rgb(255, 42, 0); text-decoration: underline;\"\u003e\u003cstrong\u003eCONSUMPTION\u003c\/strong\u003e\u003c\/span\u003e\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003cp data-start=\"79\" data-end=\"626\"\u003e\u003cstrong\u003eSurvodutide\u003c\/strong\u003e is a once-weekly, injectable \u003cstrong data-start=\"120\" data-end=\"200\"\u003edual agonist of the glucagon receptor (GCGR) and the GLP-1 receptor (GLP-1R)\u003c\/strong\u003e being co-developed by Zealand Pharma and Boehringer Ingelheim for obesity, metabolic dysfunction-associated steatohepatitis (MASH), and related cardiometabolic complications. By uniting appetite suppression (via GLP-1R) with a glucagon-driven rise in energy expenditure and hepatic fat mobilisation, it aims to deliver larger, metabolically healthier weight loss than GLP-1-only drugs. \u003cmeta charset=\"UTF-8\"\u003e\u003c\/p\u003e\n\u003cdiv class=\"_tableContainer_80l1q_1\"\u003e\n\u003cdiv class=\"_tableWrapper_80l1q_14 group flex w-fit flex-col-reverse\" tabindex=\"-1\"\u003e\n\u003ctable data-start=\"65\" data-end=\"2388\" class=\"w-fit min-w-(--thread-content-width)\"\u003e\n\u003cthead data-start=\"65\" data-end=\"95\"\u003e\n\u003ctr data-start=\"65\" data-end=\"95\"\u003e\n\u003cth data-start=\"67\" data-end=\"77\" data-col-size=\"md\"\u003eBenefit\u003c\/th\u003e\n\u003cth data-start=\"77\" data-end=\"95\" data-col-size=\"xl\"\u003eKey take-aways\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody data-start=\"110\" data-end=\"2388\"\u003e\n\u003ctr data-start=\"110\" data-end=\"373\"\u003e\n\u003ctd data-start=\"110\" data-end=\"116\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"111\" data-end=\"116\"\u003e1\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"116\" data-end=\"143\" data-col-size=\"md\"\u003e\u003cstrong data-start=\"117\" data-end=\"143\"\u003eLiver disease reversal\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"143\" data-end=\"373\" data-col-size=\"xl\"\u003eIn the Phase 2 MASH study, 83 % of patients achieved complete histologic resolution and one-third showed ≥1-stage fibrosis regression after 48 weeks—rates not yet matched by GLP-1–only drugs\u003cspan class=\"\" data-state=\"closed\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"374\" data-end=\"641\"\u003e\n\u003ctd data-start=\"374\" data-end=\"380\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"375\" data-end=\"380\"\u003e2\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"380\" data-end=\"408\" data-col-size=\"md\"\u003e\u003cstrong data-start=\"381\" data-end=\"408\"\u003ePowerful lipid lowering\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"408\" data-end=\"641\" data-col-size=\"xl\"\u003eExploratory analyses reported triglyceride falls of up to 75 %, free-fatty-acid drops of 49 %, and modest LDL\/VLDL reductions, pointing to a cardiometabolic benefit that goes beyond weight loss.\u003cspan class=\"\" data-state=\"closed\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"642\" data-end=\"879\"\u003e\n\u003ctd data-start=\"642\" data-end=\"648\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"643\" data-end=\"648\"\u003e3\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"648\" data-end=\"677\" data-col-size=\"md\"\u003e\u003cstrong data-start=\"649\" data-end=\"677\"\u003eBlood-pressure reduction\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"677\" data-end=\"879\" data-col-size=\"xl\"\u003eMean systolic\/diastolic BP fell by roughly 10\/5 mmHg alongside a 17 cm shrinkage in waist circumference—clinically relevant for hypertension and visceral-fat risk.\u003cspan class=\"\" data-state=\"closed\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"880\" data-end=\"1160\"\u003e\n\u003ctd data-start=\"880\" data-end=\"886\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"881\" data-end=\"886\"\u003e4\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"886\" data-end=\"916\" data-col-size=\"md\"\u003e\u003cstrong data-start=\"887\" data-end=\"916\"\u003eHigher energy expenditure\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"916\" data-end=\"1160\" data-col-size=\"xl\"\u003ePre-clinical work with BI 456906 shows a ~10 % rise in resting metabolic rate, suggesting the dual agonist can counteract the adaptive metabolic slowdown seen with calorie-restriction or GLP-1 monotherapy.\u003cspan class=\"\" data-state=\"closed\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"1161\" data-end=\"1403\"\u003e\n\u003ctd data-start=\"1161\" data-end=\"1167\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"1162\" data-end=\"1167\"\u003e5\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"1167\" data-end=\"1194\" data-col-size=\"md\"\u003e\u003cstrong data-start=\"1168\" data-end=\"1194\"\u003eLean-mass preservation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"1194\" data-end=\"1403\" data-col-size=\"xl\"\u003eMRI sub-studies indicate that the majority of weight lost is adipose tissue, with lean-mass loss proportionally lower than the ≈25 % seen after diet or bariatric surgery.\u003cspan class=\"\" data-state=\"closed\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"1404\" data-end=\"1626\"\u003e\n\u003ctd data-start=\"1404\" data-end=\"1410\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"1405\" data-end=\"1410\"\u003e6\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"1410\" data-end=\"1452\" data-col-size=\"md\"\u003e\u003cstrong data-start=\"1411\" data-end=\"1452\"\u003eEarly glycaemic gains in pre-diabetes\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"1452\" data-end=\"1626\" data-col-size=\"xl\"\u003eParticipants with HbA1c 5.7–6.5 % saw fasting-glucose drops of up to 13 mg\/dL by week 46, before substantial weight had even been lost.\u003cspan class=\"\" data-state=\"closed\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"1627\" data-end=\"1907\"\u003e\n\u003ctd data-start=\"1627\" data-end=\"1633\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"1628\" data-end=\"1633\"\u003e7\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"1633\" data-end=\"1661\" data-col-size=\"md\"\u003e\u003cstrong data-start=\"1634\" data-end=\"1661\"\u003eCardiac function signal\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"1661\" data-end=\"1907\" data-col-size=\"xl\"\u003eIn a diet-induced-obese hamster HFpEF model, survodutide improved diastolic function and lipid parameters independent of weight change, supporting the rationale for the ongoing cardiovascular-outcomes trial.\u003cspan class=\"\" data-state=\"closed\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"1908\" data-end=\"2132\"\u003e\n\u003ctd data-start=\"1908\" data-end=\"1914\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"1909\" data-end=\"1914\"\u003e8\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"1914\" data-end=\"1949\" data-col-size=\"md\"\u003e\u003cstrong data-start=\"1915\" data-end=\"1949\"\u003eDurable visceral-fat shrinkage\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"1949\" data-end=\"2132\" data-col-size=\"xl\"\u003eA meta-analysis (1 029 participants) found average waist-circumference reductions of 8.4 cm, scaling with dose (\u0026gt;2 mg) and exposure (\u0026gt;16 weeks).\u003cspan class=\"\" data-state=\"closed\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"2133\" data-end=\"2388\"\u003e\n\u003ctd data-start=\"2133\" data-end=\"2139\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"2134\" data-end=\"2139\"\u003e9\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"2139\" data-end=\"2192\" data-col-size=\"md\"\u003e\u003cstrong data-start=\"2140\" data-end=\"2192\"\u003eMedication de-intensification in type 2 diabetes\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"2192\" data-end=\"2388\" data-col-size=\"xl\"\u003eIn Phase 2 diabetes cohorts, HbA1c fell by up to 1.6 % within 16 weeks, allowing one-third of subjects to down-titrate or stop other glucose-lowering agents.\u003cspan class=\"\" data-state=\"closed\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cdiv class=\"sticky end-(--thread-content-margin) h-0 self-end select-none\"\u003e\n\u003cdiv class=\"absolute end-0 flex items-end\"\u003e\u003cspan class=\"\" data-state=\"closed\"\u003e\u003cbutton aria-label=\"Tabel kopiëren\" class=\"hover:bg-token-bg-tertiary text-token-text-secondary my-1 rounded-sm p-1 transition-opacity group-[:not(:hover):not(:focus-within)]:pointer-events-none group-[:not(:hover):not(:focus-within)]:opacity-0\"\u003e\u003csvg width=\"20\" height=\"20\" viewbox=\"0 0 20 20\" fill=\"currentColor\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"icon\"\u003e\u003cpath d=\"M12.668 10.667C12.668 9.95614 12.668 9.46258 12.6367 9.0791C12.6137 8.79732 12.5758 8.60761 12.5244 8.46387L12.4688 8.33399C12.3148 8.03193 12.0803 7.77885 11.793 7.60254L11.666 7.53125C11.508 7.45087 11.2963 7.39395 10.9209 7.36328C10.5374 7.33197 10.0439 7.33203 9.33301 7.33203H6.5C5.78896 7.33203 5.29563 7.33195 4.91211 7.36328C4.63016 7.38632 4.44065 7.42413 4.29688 7.47559L4.16699 7.53125C3.86488 7.68518 3.61186 7.9196 3.43555 8.20703L3.36524 8.33399C3.28478 8.49198 3.22795 8.70352 3.19727 9.0791C3.16595 9.46259 3.16504 9.95611 3.16504 10.667V13.5C3.16504 14.211 3.16593 14.7044 3.19727 15.0879C3.22797 15.4636 3.28473 15.675 3.36524 15.833L3.43555 15.959C3.61186 16.2466 3.86474 16.4807 4.16699 16.6348L4.29688 16.6914C4.44063 16.7428 4.63025 16.7797 4.91211 16.8027C5.29563 16.8341 5.78896 16.835 6.5 16.835H9.33301C10.0439 16.835 10.5374 16.8341 10.9209 16.8027C11.2965 16.772 11.508 16.7152 11.666 16.6348L11.793 16.5645C12.0804 16.3881 12.3148 16.1351 12.4688 15.833L12.5244 15.7031C12.5759 15.5594 12.6137 15.3698 12.6367 15.0879C12.6681 14.7044 12.668 14.211 12.668 13.5V10.667ZM13.998 12.665C14.4528 12.6634 14.8011 12.6602 15.0879 12.6367C15.4635 12.606 15.675 12.5492 15.833 12.4688L15.959 12.3975C16.2466 12.2211 16.4808 11.9682 16.6348 11.666L16.6914 11.5361C16.7428 11.3924 16.7797 11.2026 16.8027 10.9209C16.8341 10.5374 16.835 10.0439 16.835 9.33301V6.5C16.835 5.78896 16.8341 5.29563 16.8027 4.91211C16.7797 4.63025 16.7428 4.44063 16.6914 4.29688L16.6348 4.16699C16.4807 3.86474 16.2466 3.61186 15.959 3.43555L15.833 3.36524C15.675 3.28473 15.4636 3.22797 15.0879 3.19727C14.7044 3.16593 14.211 3.16504 13.5 3.16504H10.667C9.9561 3.16504 9.46259 3.16595 9.0791 3.19727C8.79739 3.22028 8.6076 3.2572 8.46387 3.30859L8.33399 3.36524C8.03176 3.51923 7.77886 3.75343 7.60254 4.04102L7.53125 4.16699C7.4508 4.32498 7.39397 4.53655 7.36328 4.91211C7.33985 5.19893 7.33562 5.54719 7.33399 6.00195H9.33301C10.022 6.00195 10.5791 6.00131 11.0293 6.03809C11.4873 6.07551 11.8937 6.15471 12.2705 6.34668L12.4883 6.46875C12.984 6.7728 13.3878 7.20854 13.6533 7.72949L13.7197 7.87207C13.8642 8.20859 13.9292 8.56974 13.9619 8.9707C13.9987 9.42092 13.998 9.97799 13.998 10.667V12.665ZM18.165 9.33301C18.165 10.022 18.1657 10.5791 18.1289 11.0293C18.0961 11.4302 18.0311 11.7914 17.8867 12.1279L17.8203 12.2705C17.5549 12.7914 17.1509 13.2272 16.6553 13.5313L16.4365 13.6533C16.0599 13.8452 15.6541 13.9245 15.1963 13.9619C14.8593 13.9895 14.4624 13.9935 13.9951 13.9951C13.9935 14.4624 13.9895 14.8593 13.9619 15.1963C13.9292 15.597 13.864 15.9576 13.7197 16.2939L13.6533 16.4365C13.3878 16.9576 12.9841 17.3941 12.4883 17.6982L12.2705 17.8203C11.8937 18.0123 11.4873 18.0915 11.0293 18.1289C10.5791 18.1657 10.022 18.165 9.33301 18.165H6.5C5.81091 18.165 5.25395 18.1657 4.80371 18.1289C4.40306 18.0962 4.04235 18.031 3.70606 17.8867L3.56348 17.8203C3.04244 17.5548 2.60585 17.151 2.30176 16.6553L2.17969 16.4365C1.98788 16.0599 1.90851 15.6541 1.87109 15.1963C1.83431 14.746 1.83496 14.1891 1.83496 13.5V10.667C1.83496 9.978 1.83432 9.42091 1.87109 8.9707C1.90851 8.5127 1.98772 8.10625 2.17969 7.72949L2.30176 7.51172C2.60586 7.0159 3.04236 6.6122 3.56348 6.34668L3.70606 6.28027C4.04237 6.136 4.40303 6.07083 4.80371 6.03809C5.14051 6.01057 5.53708 6.00551 6.00391 6.00391C6.00551 5.53708 6.01057 5.14051 6.03809 4.80371C6.0755 4.34588 6.15483 3.94012 6.34668 3.56348L6.46875 3.34473C6.77282 2.84912 7.20856 2.44514 7.72949 2.17969L7.87207 2.11328C8.20855 1.96886 8.56979 1.90385 8.9707 1.87109C9.42091 1.83432 9.978 1.83496 10.667 1.83496H13.5C14.1891 1.83496 14.746 1.83431 15.1963 1.87109C15.6541 1.90851 16.0599 1.98788 16.4365 2.17969L16.6553 2.30176C17.151 2.60585 17.5548 3.04244 17.8203 3.56348L17.8867 3.70606C18.031 4.04235 18.0962 4.40306 18.1289 4.80371C18.1657 5.25395 18.165 5.81091 18.165 6.5V9.33301Z\"\u003e\u003c\/path\u003e\u003c\/svg\u003e\u003c\/button\u003e\u003c\/span\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr data-start=\"628\" data-end=\"631\"\u003e\n\u003ch3 data-start=\"633\" data-end=\"663\"\u003e2. Pre-clinical insights\u003c\/h3\u003e\n\u003cp data-start=\"664\" data-end=\"1040\"\u003eRodent models fed a high-fat diet showed that survodutide \u003cstrong data-start=\"722\" data-end=\"760\"\u003eincreased total energy expenditure\u003c\/strong\u003e, lowered body weight and improved glycaemic control more than either semaglutide or long-acting glucagon analogues alone. Mechanistically, hepatic GCGR activation ramped up β-oxidation and thermogenesis, while GLP-1R agonism curbed intake. \u003cspan class=\"\" data-state=\"closed\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003chr data-start=\"1042\" data-end=\"1045\"\u003e\n\u003ch3 data-start=\"1047\" data-end=\"1091\"\u003e3. Pharmacokinetics \u0026amp; dosing principle\u003c\/h3\u003e\n\u003cp data-start=\"1092\" data-end=\"1428\"\u003eA proprietary fatty-acid side-chain extends half-life to ≈5 days, enabling once-weekly SC administration. Phase 1 studies established linear PK, no significant accumulation, and a tolerability-guided step-up schedule now standard in late-stage trials (0.3 mg start, titrated to 3.6 mg or 6.0 mg). \u003cspan class=\"\" data-state=\"closed\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003chr data-start=\"1430\" data-end=\"1433\"\u003e\n\u003ch3 data-start=\"1435\" data-end=\"1468\"\u003e4. Clinical evidence so far\u003c\/h3\u003e\n\u003cdiv class=\"_tableContainer_80l1q_1\"\u003e\n\u003cdiv class=\"_tableWrapper_80l1q_14 group flex w-fit flex-col-reverse\" tabindex=\"-1\"\u003e\n\u003ctable data-start=\"1470\" data-end=\"2082\" class=\"w-fit min-w-(--thread-content-width)\"\u003e\n\u003cthead data-start=\"1470\" data-end=\"1555\"\u003e\n\u003ctr data-start=\"1470\" data-end=\"1555\"\u003e\n\u003cth data-start=\"1470\" data-end=\"1483\" data-col-size=\"sm\"\u003eIndication\u003c\/th\u003e\n\u003cth data-start=\"1483\" data-end=\"1503\" data-col-size=\"sm\"\u003eKey study (phase)\u003c\/th\u003e\n\u003cth data-start=\"1503\" data-end=\"1523\" data-col-size=\"sm\"\u003ePopulation \u0026amp; dose\u003c\/th\u003e\n\u003cth data-start=\"1523\" data-end=\"1534\" data-col-size=\"sm\"\u003eDuration\u003c\/th\u003e\n\u003cth data-start=\"1534\" data-end=\"1555\" data-col-size=\"md\"\u003eTop-line efficacy\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody data-start=\"1641\" data-end=\"2082\"\u003e\n\u003ctr data-start=\"1641\" data-end=\"1810\"\u003e\n\u003ctd data-start=\"1641\" data-end=\"1669\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"1643\" data-end=\"1668\"\u003eObesity (no diabetes)\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"1669\" data-end=\"1693\" data-col-size=\"sm\"\u003eNCT04667377 (Phase 2)\u003c\/td\u003e\n\u003ctd data-start=\"1693\" data-end=\"1723\" data-col-size=\"sm\"\u003e4 weekly doses up to 4.8 mg\u003c\/td\u003e\n\u003ctd data-start=\"1723\" data-end=\"1730\" data-col-size=\"sm\"\u003e46 w\u003c\/td\u003e\n\u003ctd data-start=\"1730\" data-end=\"1810\" data-col-size=\"md\"\u003e−18.7 % mean weight in 4.8 mg completers; ≥15 % loss in 55 % of all-comers\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"1811\" data-end=\"1920\"\u003e\n\u003ctd data-start=\"1811\" data-end=\"1833\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"1813\" data-end=\"1832\"\u003eType 2 diabetes\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"1833\" data-end=\"1854\" data-col-size=\"sm\"\u003eRandomised Phase 2\u003c\/td\u003e\n\u003ctd data-start=\"1854\" data-end=\"1867\" data-col-size=\"sm\"\u003e0.6–3.6 mg\u003c\/td\u003e\n\u003ctd data-start=\"1867\" data-end=\"1874\" data-col-size=\"sm\"\u003e16 w\u003c\/td\u003e\n\u003ctd data-start=\"1874\" data-end=\"1920\" data-col-size=\"md\"\u003eHbA1c −1.6 % and weight −8.7 % at 3.6 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"1921\" data-end=\"2082\"\u003e\n\u003ctd data-start=\"1921\" data-end=\"1952\" data-col-size=\"sm\"\u003e\u003cstrong data-start=\"1923\" data-end=\"1951\"\u003eMASH with F2–F3 fibrosis\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"1952\" data-end=\"1969\" data-col-size=\"sm\"\u003ePhase 2 (NEJM)\u003c\/td\u003e\n\u003ctd data-start=\"1969\" data-end=\"1982\" data-col-size=\"sm\"\u003e2.4–6.0 mg\u003c\/td\u003e\n\u003ctd data-start=\"1982\" data-end=\"1989\" data-col-size=\"sm\"\u003e48 w\u003c\/td\u003e\n\u003ctd data-start=\"1989\" data-end=\"2082\" data-col-size=\"md\"\u003e83 % histologic MASH resolution vs 18 % placebo; ≥1-stage fibrosis improvement in 34–36 %\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cdiv class=\"sticky end-(--thread-content-margin) h-0 self-end select-none\"\u003e\n\u003cdiv class=\"absolute end-0 flex items-end\"\u003e\u003cspan class=\"\" data-state=\"closed\"\u003e\u003cbutton aria-label=\"Tabel kopiëren\" class=\"hover:bg-token-bg-tertiary text-token-text-secondary my-1 rounded-sm p-1 transition-opacity group-[:not(:hover):not(:focus-within)]:pointer-events-none group-[:not(:hover):not(:focus-within)]:opacity-0\"\u003e\u003csvg width=\"20\" height=\"20\" viewbox=\"0 0 20 20\" fill=\"currentColor\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"icon\"\u003e\u003cpath d=\"M12.668 10.667C12.668 9.95614 12.668 9.46258 12.6367 9.0791C12.6137 8.79732 12.5758 8.60761 12.5244 8.46387L12.4688 8.33399C12.3148 8.03193 12.0803 7.77885 11.793 7.60254L11.666 7.53125C11.508 7.45087 11.2963 7.39395 10.9209 7.36328C10.5374 7.33197 10.0439 7.33203 9.33301 7.33203H6.5C5.78896 7.33203 5.29563 7.33195 4.91211 7.36328C4.63016 7.38632 4.44065 7.42413 4.29688 7.47559L4.16699 7.53125C3.86488 7.68518 3.61186 7.9196 3.43555 8.20703L3.36524 8.33399C3.28478 8.49198 3.22795 8.70352 3.19727 9.0791C3.16595 9.46259 3.16504 9.95611 3.16504 10.667V13.5C3.16504 14.211 3.16593 14.7044 3.19727 15.0879C3.22797 15.4636 3.28473 15.675 3.36524 15.833L3.43555 15.959C3.61186 16.2466 3.86474 16.4807 4.16699 16.6348L4.29688 16.6914C4.44063 16.7428 4.63025 16.7797 4.91211 16.8027C5.29563 16.8341 5.78896 16.835 6.5 16.835H9.33301C10.0439 16.835 10.5374 16.8341 10.9209 16.8027C11.2965 16.772 11.508 16.7152 11.666 16.6348L11.793 16.5645C12.0804 16.3881 12.3148 16.1351 12.4688 15.833L12.5244 15.7031C12.5759 15.5594 12.6137 15.3698 12.6367 15.0879C12.6681 14.7044 12.668 14.211 12.668 13.5V10.667ZM13.998 12.665C14.4528 12.6634 14.8011 12.6602 15.0879 12.6367C15.4635 12.606 15.675 12.5492 15.833 12.4688L15.959 12.3975C16.2466 12.2211 16.4808 11.9682 16.6348 11.666L16.6914 11.5361C16.7428 11.3924 16.7797 11.2026 16.8027 10.9209C16.8341 10.5374 16.835 10.0439 16.835 9.33301V6.5C16.835 5.78896 16.8341 5.29563 16.8027 4.91211C16.7797 4.63025 16.7428 4.44063 16.6914 4.29688L16.6348 4.16699C16.4807 3.86474 16.2466 3.61186 15.959 3.43555L15.833 3.36524C15.675 3.28473 15.4636 3.22797 15.0879 3.19727C14.7044 3.16593 14.211 3.16504 13.5 3.16504H10.667C9.9561 3.16504 9.46259 3.16595 9.0791 3.19727C8.79739 3.22028 8.6076 3.2572 8.46387 3.30859L8.33399 3.36524C8.03176 3.51923 7.77886 3.75343 7.60254 4.04102L7.53125 4.16699C7.4508 4.32498 7.39397 4.53655 7.36328 4.91211C7.33985 5.19893 7.33562 5.54719 7.33399 6.00195H9.33301C10.022 6.00195 10.5791 6.00131 11.0293 6.03809C11.4873 6.07551 11.8937 6.15471 12.2705 6.34668L12.4883 6.46875C12.984 6.7728 13.3878 7.20854 13.6533 7.72949L13.7197 7.87207C13.8642 8.20859 13.9292 8.56974 13.9619 8.9707C13.9987 9.42092 13.998 9.97799 13.998 10.667V12.665ZM18.165 9.33301C18.165 10.022 18.1657 10.5791 18.1289 11.0293C18.0961 11.4302 18.0311 11.7914 17.8867 12.1279L17.8203 12.2705C17.5549 12.7914 17.1509 13.2272 16.6553 13.5313L16.4365 13.6533C16.0599 13.8452 15.6541 13.9245 15.1963 13.9619C14.8593 13.9895 14.4624 13.9935 13.9951 13.9951C13.9935 14.4624 13.9895 14.8593 13.9619 15.1963C13.9292 15.597 13.864 15.9576 13.7197 16.2939L13.6533 16.4365C13.3878 16.9576 12.9841 17.3941 12.4883 17.6982L12.2705 17.8203C11.8937 18.0123 11.4873 18.0915 11.0293 18.1289C10.5791 18.1657 10.022 18.165 9.33301 18.165H6.5C5.81091 18.165 5.25395 18.1657 4.80371 18.1289C4.40306 18.0962 4.04235 18.031 3.70606 17.8867L3.56348 17.8203C3.04244 17.5548 2.60585 17.151 2.30176 16.6553L2.17969 16.4365C1.98788 16.0599 1.90851 15.6541 1.87109 15.1963C1.83431 14.746 1.83496 14.1891 1.83496 13.5V10.667C1.83496 9.978 1.83432 9.42091 1.87109 8.9707C1.90851 8.5127 1.98772 8.10625 2.17969 7.72949L2.30176 7.51172C2.60586 7.0159 3.04236 6.6122 3.56348 6.34668L3.70606 6.28027C4.04237 6.136 4.40303 6.07083 4.80371 6.03809C5.14051 6.01057 5.53708 6.00551 6.00391 6.00391C6.00551 5.53708 6.01057 5.14051 6.03809 4.80371C6.0755 4.34588 6.15483 3.94012 6.34668 3.56348L6.46875 3.34473C6.77282 2.84912 7.20856 2.44514 7.72949 2.17969L7.87207 2.11328C8.20855 1.96886 8.56979 1.90385 8.9707 1.87109C9.42091 1.83432 9.978 1.83496 10.667 1.83496H13.5C14.1891 1.83496 14.746 1.83431 15.1963 1.87109C15.6541 1.90851 16.0599 1.98788 16.4365 2.17969L16.6553 2.30176C17.151 2.60585 17.5548 3.04244 17.8203 3.56348L17.8867 3.70606C18.031 4.04235 18.0962 4.40306 18.1289 4.80371C18.1657 5.25395 18.165 5.81091 18.165 6.5V9.33301Z\"\u003e\u003c\/path\u003e\u003c\/svg\u003e\u003c\/button\u003e\u003c\/span\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp data-start=\"2084\" data-end=\"2245\"\u003e\u003cem data-start=\"2084\" data-end=\"2107\"\u003eObesity trial sources\u003c\/em\u003e \u003cspan class=\"\" data-state=\"closed\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003ca href=\"https:\/\/www.ajmc.com\/view\/patients-with-overweight-or-obesity-show-significant-weight-loss-in-phase-2-survodutide-trial?utm_source=chatgpt.com\" rel=\"noopener\" alt=\"https:\/\/www.ajmc.com\/view\/patients-with-overweight-or-obesity-show-significant-weight-loss-in-phase-2-survodutide-trial?utm_source=chatgpt.com\" class=\"flex h-4.5 overflow-hidden rounded-xl px-2 text-[9px] font-medium text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! transition-colors duration-150 ease-in-out\" target=\"_blank\"\u003e\u003cspan class=\"relative start-0 bottom-0 flex h-full w-full items-center\"\u003e\u003cspan class=\"flex h-4 w-full items-center justify-between overflow-hidden\"\u003e\u003cspan class=\"max-w-full grow truncate overflow-hidden text-center\"\u003eAJMC\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/span\u003e\u003cspan class=\"\" data-state=\"closed\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003ca href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11664303\/?utm_source=chatgpt.com\" rel=\"noopener\" alt=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11664303\/?utm_source=chatgpt.com\" class=\"flex h-4.5 overflow-hidden rounded-xl px-2 text-[9px] font-medium text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! transition-colors duration-150 ease-in-out\" target=\"_blank\"\u003e\u003cspan class=\"relative start-0 bottom-0 flex h-full w-full items-center\"\u003e\u003cspan class=\"flex h-4 w-full items-center justify-between overflow-hidden\"\u003e\u003cspan class=\"max-w-full grow truncate overflow-hidden text-center\"\u003ePMC\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/span\u003e – \u003cem data-start=\"2148\" data-end=\"2158\"\u003eDiabetes\u003c\/em\u003e \u003cspan class=\"\" data-state=\"closed\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003ca href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10844353\/?utm_source=chatgpt.com\" rel=\"noopener\" alt=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10844353\/?utm_source=chatgpt.com\" class=\"flex h-4.5 overflow-hidden rounded-xl px-2 text-[9px] font-medium text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! transition-colors duration-150 ease-in-out\" target=\"_blank\"\u003e\u003cspan class=\"relative start-0 bottom-0 flex h-full w-full items-center\"\u003e\u003cspan class=\"flex h-4 w-full items-center justify-between overflow-hidden\"\u003e\u003cspan class=\"max-w-full grow truncate overflow-hidden text-center\"\u003ePMC\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/span\u003e – \u003cem data-start=\"2199\" data-end=\"2205\"\u003eMASH\u003c\/em\u003e \u003cspan class=\"\" data-state=\"closed\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003ca href=\"https:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa2401755?utm_source=chatgpt.com\" rel=\"noopener\" alt=\"https:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa2401755?utm_source=chatgpt.com\" class=\"flex h-4.5 overflow-hidden rounded-xl px-2 text-[9px] font-medium text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! transition-colors duration-150 ease-in-out\" target=\"_blank\"\u003e\u003cspan class=\"relative start-0 bottom-0 flex h-full w-full items-center\"\u003e\u003cspan class=\"flex h-4 w-full items-center justify-between overflow-hidden\"\u003e\u003cspan class=\"max-w-full grow truncate overflow-hidden text-center\"\u003eNew England Journal of Medicine\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/span\u003e\u003cspan class=\"\" data-state=\"closed\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38847460\/?utm_source=chatgpt.com\" rel=\"noopener\" alt=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38847460\/?utm_source=chatgpt.com\" class=\"flex h-4.5 overflow-hidden rounded-xl px-2 text-[9px] font-medium text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! transition-colors duration-150 ease-in-out\" target=\"_blank\"\u003e\u003cspan class=\"relative start-0 bottom-0 flex h-full w-full items-center\"\u003e\u003cspan class=\"flex h-4 w-full items-center justify-between overflow-hidden\"\u003e\u003cspan class=\"max-w-full grow truncate overflow-hidden text-center\"\u003ePubMed\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/span\u003e\u003cspan class=\"\" data-state=\"closed\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003ca href=\"https:\/\/www.ft.com\/content\/0a75f311-f960-4f81-9c11-00e14923ecef?utm_source=chatgpt.com\" rel=\"noopener\" alt=\"https:\/\/www.ft.com\/content\/0a75f311-f960-4f81-9c11-00e14923ecef?utm_source=chatgpt.com\" class=\"flex h-4.5 overflow-hidden rounded-xl px-2 text-[9px] font-medium text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! transition-colors duration-150 ease-in-out\" target=\"_blank\"\u003e\u003cspan class=\"relative start-0 bottom-0 flex h-full w-full items-center\"\u003e\u003cspan class=\"flex h-4 w-full items-center justify-between overflow-hidden\"\u003e\u003cspan class=\"max-w-full grow truncate overflow-hidden text-center\"\u003eFinancial Times\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp data-start=\"2247\" data-end=\"2569\"\u003e\u003cstrong data-start=\"2247\" data-end=\"2265\"\u003eSafety profile\u003c\/strong\u003e – Across trials, gastrointestinal events dominate (nausea ≈ 66 %, vomiting ≈ 41 %, diarrhoea ≈ 49 % at therapeutic doses). Serious AEs were comparable to placebo, but discontinuation risk is ~4-fold higher than placebo—driving the lengthened titration in phase 3. \u003cspan class=\"\" data-state=\"closed\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38847460\/?utm_source=chatgpt.com\" rel=\"noopener\" alt=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38847460\/?utm_source=chatgpt.com\" class=\"flex h-4.5 overflow-hidden rounded-xl px-2 text-[9px] font-medium text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! transition-colors duration-150 ease-in-out\" target=\"_blank\"\u003e\u003cspan class=\"relative start-0 bottom-0 flex h-full w-full items-center\"\u003e\u003cspan class=\"flex h-4 w-full items-center justify-between overflow-hidden\"\u003e\u003cspan class=\"max-w-full grow truncate overflow-hidden text-center\"\u003ePubMed\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/span\u003e\u003cspan class=\"\" data-state=\"closed\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003ca href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12184113\/?utm_source=chatgpt.com\" rel=\"noopener\" alt=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12184113\/?utm_source=chatgpt.com\" class=\"flex h-4.5 overflow-hidden rounded-xl px-2 text-[9px] font-medium text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! transition-colors duration-150 ease-in-out\" target=\"_blank\"\u003e\u003cspan class=\"relative start-0 bottom-0 flex h-full w-full items-center\"\u003e\u003cspan class=\"flex h-4 w-full items-center justify-between overflow-hidden\"\u003e\u003cspan class=\"max-w-full grow truncate overflow-hidden text-center\"\u003ePMC\u003c\/span\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003chr data-start=\"2571\" data-end=\"2574\"\u003e\n\u003ch3 data-start=\"2576\" data-end=\"2614\"\u003e5. Phase 3 programme (2025 status)\u003c\/h3\u003e\n\u003cdiv class=\"_tableContainer_80l1q_1\"\u003e\n\u003cdiv class=\"_tableWrapper_80l1q_14 group flex w-fit flex-col-reverse\" tabindex=\"-1\"\u003e\n\u003ctable data-start=\"2616\" data-end=\"3345\" class=\"w-fit min-w-(--thread-content-width)\" style=\"width: 100%;\"\u003e\n\u003cthead data-start=\"2616\" data-end=\"2689\"\u003e\n\u003ctr data-start=\"2616\" data-end=\"2689\"\u003e\n\u003cth data-start=\"2616\" data-end=\"2628\" data-col-size=\"sm\" style=\"width: 20.418848%;\"\u003eProgramme\u003c\/th\u003e\n\u003cth data-start=\"2628\" data-end=\"2648\" data-col-size=\"sm\" style=\"width: 22.862129%;\"\u003eTarget cohort (N)\u003c\/th\u003e\n\u003cth data-start=\"2648\" data-end=\"2668\" data-col-size=\"sm\" style=\"width: 27.34684%;\"\u003ePrimary end-point\u003c\/th\u003e\n\u003cth data-start=\"2668\" data-end=\"2689\" data-col-size=\"md\" style=\"width: 27.626982%;\"\u003eStatus \/ read-out\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody data-start=\"2764\" data-end=\"3345\"\u003e\n\u003ctr data-start=\"2764\" data-end=\"2927\"\u003e\n\u003ctd data-start=\"2764\" data-end=\"2784\" data-col-size=\"sm\" style=\"width: 20.418848%;\"\u003e\u003cstrong data-start=\"2766\" data-end=\"2783\"\u003eSYNCHRONIZE-1\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"2784\" data-end=\"2811\" data-col-size=\"sm\" style=\"width: 22.862129%;\"\u003eObesity, no T2D (≈ 7 00)\u003c\/td\u003e\n\u003ctd data-start=\"2811\" data-end=\"2849\" data-col-size=\"sm\" style=\"width: 27.34684%;\"\u003e≥ 5 % \u0026amp; ≥ 10 % weight loss at wk 76\u003c\/td\u003e\n\u003ctd data-start=\"2849\" data-end=\"2927\" data-col-size=\"md\" style=\"width: 27.626982%;\"\u003e\n\u003cem data-start=\"2851\" data-end=\"2887\"\u003eLast patient out expected Dec 2025\u003c\/em\u003e \u003cspan class=\"\" data-state=\"closed\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"2928\" data-end=\"2992\"\u003e\n\u003ctd data-start=\"2928\" data-end=\"2948\" data-col-size=\"sm\" style=\"width: 20.418848%;\"\u003e\u003cstrong data-start=\"2930\" data-end=\"2947\"\u003eSYNCHRONIZE-2\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"2948\" data-end=\"2964\" data-col-size=\"sm\" style=\"width: 22.862129%;\"\u003eObesity + T2D\u003c\/td\u003e\n\u003ctd data-start=\"2964\" data-end=\"2971\" data-col-size=\"sm\" style=\"width: 27.34684%;\"\u003eSame\u003c\/td\u003e\n\u003ctd data-start=\"2971\" data-end=\"2992\" data-col-size=\"md\" style=\"width: 27.626982%;\"\u003eParallel timeline\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"2993\" data-end=\"3178\"\u003e\n\u003ctd data-start=\"2993\" data-end=\"3029\" data-col-size=\"sm\" style=\"width: 20.418848%;\"\u003e\u003cstrong data-start=\"2995\" data-end=\"3028\"\u003eLIVERAGE \/ LIVERAGE-Cirrhosis\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"3029\" data-end=\"3047\" data-col-size=\"sm\" style=\"width: 22.862129%;\"\u003eMASH F2–F3 \/ F4\u003c\/td\u003e\n\u003ctd data-start=\"3047\" data-end=\"3082\" data-col-size=\"sm\" style=\"width: 27.34684%;\"\u003eHistologic resolution ± fibrosis\u003c\/td\u003e\n\u003ctd data-start=\"3082\" data-end=\"3178\" data-col-size=\"md\" style=\"width: 27.626982%;\"\u003eRecruiting; baseline imaging \u0026amp; NIT poster at EASL 2025 \u003cspan class=\"\" data-state=\"closed\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr data-start=\"3179\" data-end=\"3345\"\u003e\n\u003ctd data-start=\"3179\" data-end=\"3202\" data-col-size=\"sm\" style=\"width: 20.418848%;\"\u003e\u003cstrong data-start=\"3181\" data-end=\"3201\"\u003eSYNCHRONIZE-CVOT\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd data-start=\"3202\" data-end=\"3244\" data-col-size=\"sm\" style=\"width: 22.862129%;\"\u003eObesity\/overweight with CV risk (4 935)\u003c\/td\u003e\n\u003ctd data-start=\"3244\" data-end=\"3259\" data-col-size=\"sm\" style=\"width: 27.34684%;\"\u003e5-point MACE\u003c\/td\u003e\n\u003ctd data-start=\"3259\" data-end=\"3345\" data-col-size=\"md\" style=\"width: 27.626982%;\"\u003eActive, not recruiting; last update Jul 2025 \u003cspan class=\"\" data-state=\"closed\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cdiv class=\"sticky end-(--thread-content-margin) h-0 self-end select-none\"\u003e\n\u003cdiv class=\"absolute end-0 flex items-end\"\u003e\u003cspan class=\"\" data-state=\"closed\"\u003e\u003cbutton aria-label=\"Tabel kopiëren\" class=\"hover:bg-token-bg-tertiary text-token-text-secondary my-1 rounded-sm p-1 transition-opacity group-[:not(:hover):not(:focus-within)]:pointer-events-none group-[:not(:hover):not(:focus-within)]:opacity-0\"\u003e\u003csvg width=\"20\" height=\"20\" viewbox=\"0 0 20 20\" fill=\"currentColor\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"icon\"\u003e\u003cpath d=\"M12.668 10.667C12.668 9.95614 12.668 9.46258 12.6367 9.0791C12.6137 8.79732 12.5758 8.60761 12.5244 8.46387L12.4688 8.33399C12.3148 8.03193 12.0803 7.77885 11.793 7.60254L11.666 7.53125C11.508 7.45087 11.2963 7.39395 10.9209 7.36328C10.5374 7.33197 10.0439 7.33203 9.33301 7.33203H6.5C5.78896 7.33203 5.29563 7.33195 4.91211 7.36328C4.63016 7.38632 4.44065 7.42413 4.29688 7.47559L4.16699 7.53125C3.86488 7.68518 3.61186 7.9196 3.43555 8.20703L3.36524 8.33399C3.28478 8.49198 3.22795 8.70352 3.19727 9.0791C3.16595 9.46259 3.16504 9.95611 3.16504 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3.36524C15.675 3.28473 15.4636 3.22797 15.0879 3.19727C14.7044 3.16593 14.211 3.16504 13.5 3.16504H10.667C9.9561 3.16504 9.46259 3.16595 9.0791 3.19727C8.79739 3.22028 8.6076 3.2572 8.46387 3.30859L8.33399 3.36524C8.03176 3.51923 7.77886 3.75343 7.60254 4.04102L7.53125 4.16699C7.4508 4.32498 7.39397 4.53655 7.36328 4.91211C7.33985 5.19893 7.33562 5.54719 7.33399 6.00195H9.33301C10.022 6.00195 10.5791 6.00131 11.0293 6.03809C11.4873 6.07551 11.8937 6.15471 12.2705 6.34668L12.4883 6.46875C12.984 6.7728 13.3878 7.20854 13.6533 7.72949L13.7197 7.87207C13.8642 8.20859 13.9292 8.56974 13.9619 8.9707C13.9987 9.42092 13.998 9.97799 13.998 10.667V12.665ZM18.165 9.33301C18.165 10.022 18.1657 10.5791 18.1289 11.0293C18.0961 11.4302 18.0311 11.7914 17.8867 12.1279L17.8203 12.2705C17.5549 12.7914 17.1509 13.2272 16.6553 13.5313L16.4365 13.6533C16.0599 13.8452 15.6541 13.9245 15.1963 13.9619C14.8593 13.9895 14.4624 13.9935 13.9951 13.9951C13.9935 14.4624 13.9895 14.8593 13.9619 15.1963C13.9292 15.597 13.864 15.9576 13.7197 16.2939L13.6533 16.4365C13.3878 16.9576 12.9841 17.3941 12.4883 17.6982L12.2705 17.8203C11.8937 18.0123 11.4873 18.0915 11.0293 18.1289C10.5791 18.1657 10.022 18.165 9.33301 18.165H6.5C5.81091 18.165 5.25395 18.1657 4.80371 18.1289C4.40306 18.0962 4.04235 18.031 3.70606 17.8867L3.56348 17.8203C3.04244 17.5548 2.60585 17.151 2.30176 16.6553L2.17969 16.4365C1.98788 16.0599 1.90851 15.6541 1.87109 15.1963C1.83431 14.746 1.83496 14.1891 1.83496 13.5V10.667C1.83496 9.978 1.83432 9.42091 1.87109 8.9707C1.90851 8.5127 1.98772 8.10625 2.17969 7.72949L2.30176 7.51172C2.60586 7.0159 3.04236 6.6122 3.56348 6.34668L3.70606 6.28027C4.04237 6.136 4.40303 6.07083 4.80371 6.03809C5.14051 6.01057 5.53708 6.00551 6.00391 6.00391C6.00551 5.53708 6.01057 5.14051 6.03809 4.80371C6.0755 4.34588 6.15483 3.94012 6.34668 3.56348L6.46875 3.34473C6.77282 2.84912 7.20856 2.44514 7.72949 2.17969L7.87207 2.11328C8.20855 1.96886 8.56979 1.90385 8.9707 1.87109C9.42091 1.83432 9.978 1.83496 10.667 1.83496H13.5C14.1891 1.83496 14.746 1.83431 15.1963 1.87109C15.6541 1.90851 16.0599 1.98788 16.4365 2.17969L16.6553 2.30176C17.151 2.60585 17.5548 3.04244 17.8203 3.56348L17.8867 3.70606C18.031 4.04235 18.0962 4.40306 18.1289 4.80371C18.1657 5.25395 18.165 5.81091 18.165 6.5V9.33301Z\"\u003e\u003c\/path\u003e\u003c\/svg\u003e\u003c\/button\u003e\u003c\/span\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp data-start=\"3347\" data-end=\"3469\"\u003eBoehringer projects first filings \u003cstrong data-start=\"3381\" data-end=\"3395\"\u003ein 2027–28\u003c\/strong\u003e if these trials meet endpoints\u003cmeta charset=\"UTF-8\"\u003e\u003c\/p\u003e\n\u003ch3 data-start=\"2395\" data-end=\"2411\"\u003eReferences\u003c\/h3\u003e\n\u003col data-start=\"2412\" data-end=\"4099\"\u003e\n\u003cli data-start=\"2412\" data-end=\"2579\"\u003e\n\u003cp data-start=\"2415\" data-end=\"2579\"\u003eSanyal AJ et al. \u003cem data-start=\"2432\" data-end=\"2520\"\u003eA Phase 2 Randomized Trial of Survodutide in Adults with MASH and Fibrosis Stages 1–3.\u003c\/em\u003e N Engl J Med 2024.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"2412\" data-end=\"2579\"\u003e\n\u003cp data-start=\"2415\" data-end=\"2579\"\u003eLucas KJ et al. “Survodutide Weight Loss Is Associated with Changes in Plasma Free-Fatty Acids and Triglycerides.” ADA abstract 1635-P, 2024; and Le Roux CW et al. \u003cem data-start=\"2747\" data-end=\"2820\"\u003eSurvodutide Improves Cardiometabolic Parameters in Adults with Obesity.\u003c\/em\u003e Eur Heart J Suppl 2024. \u003cspan class=\"\" data-state=\"closed\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"2887\" data-end=\"3158\"\u003e\n\u003cp data-start=\"2890\" data-end=\"3158\"\u003eLe Roux CW et al. \u003cem data-start=\"2908\" data-end=\"2981\"\u003eSurvodutide Improves Cardiometabolic Parameters in Adults with Obesity.\u003c\/em\u003e Eur Heart J Suppl 2024; plus Hennige AM et al. “Survodutide: A Promising Agent for Obesity and Type 2 Diabetes.” Auctores Online 2025. \u003cspan class=\"\" data-state=\"closed\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"3159\" data-end=\"3334\"\u003e\n\u003cp data-start=\"3162\" data-end=\"3334\"\u003eMüller TD et al. “Discovery and Pre-clinical Pharmacology of the GCGR\/GLP-1R Dual Agonist BI 456906.” \u003cem data-start=\"3264\" data-end=\"3286\"\u003eMolecular Metabolism\u003c\/em\u003e 2023. \u003cspan class=\"\" data-state=\"closed\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"3335\" data-end=\"3527\"\u003e\n\u003cp data-start=\"3338\" data-end=\"3527\"\u003eLe Roux CW et al. “Glucagon and GLP-1 Receptor Dual Agonist Survodutide for Obesity: Body-Composition Findings.” \u003cem data-start=\"3451\" data-end=\"3479\"\u003eLancet Diabetes Endocrinol\u003c\/em\u003e 2024. \u003cspan class=\"\" data-state=\"closed\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"3528\" data-end=\"3631\"\u003e\n\u003cp data-start=\"3531\" data-end=\"3631\"\u003eAbstract 6926. 19th Cardiometabolic Health Congress, 2024. \u003cspan class=\"\" data-state=\"closed\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"3632\" data-end=\"3769\"\u003e\n\u003cp data-start=\"3635\" data-end=\"3769\"\u003eADA 2025 abstract 1704-P. “Survodutide Improves HFpEF and Dyslipidaemia in a Hamster Model.” \u003cspan class=\"\" data-state=\"closed\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"3770\" data-end=\"3955\"\u003e\n\u003cp data-start=\"3773\" data-end=\"3955\"\u003eShi LL et al. “Effect of Survodutide on Weight, BMI and Waist Circumference: Meta-analysis of 18 Study Groups.” \u003cem data-start=\"3885\" data-end=\"3907\"\u003eDiabetol Metab Syndr\u003c\/em\u003e 2024. \u003cspan class=\"\" data-state=\"closed\"\u003e\u003cspan class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\"\u003e\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"3956\" data-end=\"4099\"\u003e\n\u003cp data-start=\"3959\" data-end=\"4099\"\u003eNuijten MAH et al. \u003cem data-start=\"3978\" data-end=\"4043\"\u003eSurvodutide Trial Rationale in Type 2 Diabetes (SYNCHRONIZE-2).\u003c\/em\u003e \u003cem data-start=\"4044\" data-end=\"4053\"\u003eObesity\u003c\/em\u003e 2025.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp data-start=\"3347\" data-end=\"3469\"\u003e \u003c\/p\u003e","brand":"RCpeptides","offers":[{"title":"Default Title","offer_id":52684855705938,"sku":null,"price":90.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1048\/0956\/2450\/files\/Survodutide_10mg.png?v=1770834882","url":"https:\/\/sciencepeptideslab.com\/products\/survodutide-10mg-vial","provider":"Science Peptides Lab","version":"1.0","type":"link"}